Explore a shared vulnerability in two of the childhood brain tumor's types, opening opportunities for targeted therapies in patients with high-risk disease.

Explore new St. Jude research finding how removing the immune response “brake” gene ZMYND8 led to better control of solid tumors and chronic viral infections.

See how a machine-learning drug discovery platform for ultra-large virtual screenings called AdaptiveFlow guides the rational selection for deeper exploration

Discover how St. Jude researchers uncovered how regional differences in the developing brain shape diffuse midline glioma formation.

Explore a cellular immunotherapy that controlled relapsed bone cancer and prevented metastasis in model systems, setting the foundation for a clinical trial.

Explore new St. Jude research uncovering a special set of interneurons that governs how the brain controls the speed of certain repetitive body movements.

Discover how the RNA-binding protein MBNL1 binds single-stranded DNA to promote a difficult-to-treat childhood cancer.

See how a synthetic gene regulating SynGR system desilenced the frataxin gene in Friedreich’s ataxia by shuttling BRD4 through HP1 condensates

Discover how St. Jude researchers discovered a new mechanism that enhances Sonic hedgehog signaling during heart and lung development.

Sickle cell disease–induced hematopoietic stem cell senescence and loss of function are reversed in SCD mice by treatments targeting senescence.

Discover how patients with sickle cell disease have accelerated aging in their blood stem cells, but anti-aging senolytics may help, and improve gene therapy.

See how bacteria survive antibiotic treatment by entering a temporary state of tolerance driven by changes in RNA regulation.

Learn how RBM5 helps drive disease while being dispensable in normal blood-forming cells, offering a potential high-efficacy, low toxicity therapeutic target.

See how RNA and SURF6 sub-compartments surrounded by NPM1 help in ribosome biogenesis within the nucleolus granular component condensate

See how an inactive tumor suppressor SPOP ‘double-donut’ state is converted to an active filament state with Cullin-3 to ubiquitinate key proteins like BRD4

Find how the blood cancers without effective treatments showed a selective vulnerability to the drug, providing a new potential therapeutic avenue to explore.

See how C1 neurons within the rostral ventrolateral medulla (RVLM) connect to periaqueductal grey matter and are activated under conditions prolonged anxiety.