Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...

and some very useful numbers about human genomes to get you started!

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

Genome engineering research led by Jonas Koeppel, developing scalable technologies to design structural variants and study mammalian genome function.

A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.

YouTube video by allen institute

Russell Vought is going destroy American Science

Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.

Pooled production of recombinant AAV vectors leads to frequent genetic recombination.

Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.

Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

In this preprint the authors propose a shift in what counts in the biomedical sciences: researchers should be recognized for what they choose to share on their own terms and timeline (for example as p...

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

The ability to design and engineer mammalian genomes across arbitrary length scales would transform biology and medicine. Such capabilities would enab…

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...

Prime editing in mammalian cells benefits from a comprehensive list of genetic parts.

The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...