iiinova — where your digital self keeps evolving

Reposted by Masashi Nomura

Roel Verhaak @roelverhaak.bsky.social · 04/06/2026

In our new collaborative paper on IDHmutant glioma with the Tirosh, Suva, Iavarone and Lasorella labs, we show how acquired genetic alterations converge with cell state changes and poor treatment responses. www.nature.com/articles/s41...

nature.com

Acquired genetic and cell-state changes in IDH-mutant glioma progression - Nature

Longitudinal transcriptomic, chromatin and genomic analyses of the two types of IDH-mutant glioma reveal in detail how disease progression is influenced by interdependent genetic, epigenetic and micro...

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Masashi Nomura @masashi-nomura.bsky.social · 19/12/2025

Excited to purchase the pipette sets and sample coolers—tools I used during my time in the Suvà lab. Thank you, Mitsubishi Foundation, for supporting our research!

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Reposted by Masashi Nomura

Avishay Spitzer, MD, PhD @avishayspitzer.bsky.social · 10/05/2025

14/ Big thanks also to the institutions that provided tumor samples @dukepress.bsky.social, @mdanderson.bsky.social, Tokyo University Hospital, Pitié-Salpêtrière Hospital, St. Michael's Hospital, Seoul National University and NORLUX and funders NIH, NCI, Mark Foundation and Sontag Foundation.

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Reposted by Masashi Nomura

Avishay Spitzer, MD, PhD @avishayspitzer.bsky.social · 10/05/2025

13/ @weizmanninstitute.bsky.social, Mass General Brigham (Cancer Center, Pathology), @broadinstitute.org, @yalepress.bsky.social and University of Miami.

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Reposted by Masashi Nomura

Avishay Spitzer, MD, PhD @avishayspitzer.bsky.social · 10/05/2025

12/ Big thanks to the PIs that supervised the project @itaytirosh.bsky.social, @suvalab.bsky.social, @roelverhaak.bsky.social, Antonio Iavarone and Anna Lasorella, all collaborators and institutions involved in the CARE consortium >

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Reposted by Masashi Nomura

Avishay Spitzer, MD, PhD @avishayspitzer.bsky.social · 10/05/2025

4/ And now for the results! Across the cohort the most consistent change at recurrence was reduced malignant cell fraction, with a reciprocal increase in glial and neuronal TME cells. This was observed in ~66% of patients, suggesting increased tumor integration into brain tissue.

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Reposted by Masashi Nomura

Avishay Spitzer, MD, PhD @avishayspitzer.bsky.social · 10/05/2025

3/ We first leveraged this large cohort to revisit the intra- and inter-tumor heterogeneity in GBM and characterized three multi-layered transcriptional ecosystems. Read more about this study in this great thread by @masashi-nomura.bsky.social → bsky.app/profile/masa...

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