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Abstract. Gene expression patterns are determined to a large extent by transcription factor (TF) binding to noncoding regulatory regions in the genome. How

This repository contains fine mapped eQTL and sQTL summary statistics from the INTERVAL RNA-seq study (Tokolyi et al, 2025). Datasets QTD001000-QTD001002 are based on the whole cohort of 4,729 samples...

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

Proceedings of the 20th Machine Learning in Computational Biology meeting Held in New York, NY, USA on 10-11 September 2025 Published as Volume 311 by the Proceedings of Machine Learning Research on 3...

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The authors give a method for learning causal gene networks using Perturb-seq data. In K562 cells, they find a network with small-world and scale-free properties. Analysis shows a relationship between...

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The majority of human genes can produce multiple isoforms, but studying their functional relevance requires tools to target specific isoforms. Here, the authors develop a CRISPR-based exon-exon juncti...

Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...

Youtube channel for the Machine Learning in Computational Biology conference.

Youtube channel for the Machine Learning in Computational Biology conference: https://mlcb.github.io/

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Amazon.com: An Intuitive Primer on Effective Functional Genomics Study Design: 9798218585952: Gilad, Yoav: Books

T cell therapies, such as chimeric antigen receptor (CAR) T cells and T cell receptor (TCR) T cells, are a growing class of anti-cancer treatments. However, expansion to novel indications and beyond l...

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Hi all. I have a model which is a hierarchy of GLMs where I want to test a null vs full model for each sub-GLM (there are params shared between these GLMs in the real version although not in the MWE b...

As polygenic prediction extends beyond the research domain to involve clinical applications, the urgency of solving the “portability problem” becomes amplified—that is, the fact that polygenic indices...

Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by anal...