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Michael Kharas

@kharaslab.bsky.social
216 followers 28 following 3 posts

Professor scientist lab head

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Reposted by Michael Kharas
Vijay G. Sankaran @bloodgenes.bsky.social · 02/01/2026
And nice coverage by @angusrohan.bsky.social from @statnews.com (3/n): www.statnews.com/2026/01/01/b...
statnews.com
Genetic variant appears to protect some people against certain blood cancers
Researchers found a genetic variant that appears to protect against the development of CHIP, a phenomenon that can lead to certain blood cancers
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Reposted by Michael Kharas
Vijay G. Sankaran @bloodgenes.bsky.social · 02/01/2026
Please check out this terrific preview from Caido & Manz (2/n): www.science.org/doi/10.1126/...
science.org
Genetic resistance to leukemia
A genome-wide association study identifies a genetic variant that reduces the risk of leukemia
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Reposted by Michael Kharas
Vijay G. Sankaran @bloodgenes.bsky.social · 02/01/2026
Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵
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Reposted by Michael Kharas
Eric Topol @erictopol.bsky.social · 01/01/2026
New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...
science.org
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
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Michael Kharas @kharaslab.bsky.social · 04/07/2025
HAPPY 4th and excited to be part of this. Congrats to the talented Dr. Harold Elias for getting this epic Nature Comm story rdcu.be/euQb7 on how kitlow HSCs have superior thymic reconstitution. Big congrats to Marcel Van Den Brink and all of our collaborators!! .
rdcu.be
Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution
Nature Communications - Hematopoietic stem cells (HSCs) differentiate into multiple lineages, with such capacity impacted by aging. Here the authors identify Kitlo HSCs as a functionally distinct...
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Reposted by Michael Kharas
Vijay G. Sankaran @bloodgenes.bsky.social · 27/03/2025
So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇
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