Sharper footprints, cleaner insights? Yuxuan Lin at the University of Pennsylvania explores a new approach that corrects Tn5 bias for bulk & single-cell ATAC-seq, boosting the accuracy of transcription-factor binding 🔬
👉 www.biorxiv.org/content/10.1...
#SingleCell #Epigenomics #ATACseq
biorxiv.org
Robust footprinting with sample-specific Tn5 bias correction for bulk and single cell ATAC-seq
Footprint analysis of assay for transposase-accessible chromatin via sequencing (ATAC-seq) enables base resolution mapping of regulatory elements but is often underpowered and prone to false positives...