iiinova — where your digital self keeps evolving

Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social A temporal threshold in TGF-β signaling separates reversible tissue adaptation from persistent NK cell effector dysfunction www.biorxiv.org/content/10.6... @gmwiedemann-lab.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy www.biorxiv.org/content/10.6... @kamphorstlab.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social Lymphatic networks enable diversification of B cell responses to vaccines www.biorxiv.org/content/10.6... @uwmedicine.bsky.social @michael-gerner.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

A metabolic–oxidative axis contributes to NK cell cryo-vulnerability www.sciencedirect.com/science/arti...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social Multi-scale gene regulatory networks for resolving transcription factor and autoimmune variant impacts on human B cell fate dynamics www.biorxiv.org/content/10.1...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

A key role for age-associated senescent CD4+ T cells in driving age-associated autoimmunity @biorxivpreprint.bsky.social www.biorxiv.org/content/10.6... @acovarrubias.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

Maternal HIV Exposure Is Associated With Transient Transcriptional Changes in Monocytes and Natural Killer Cells in Early Infancy academic.oup.com/jid/advance-...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

Career perspective of @davidraulet.bsky.social Hazy mysteries and the major histocompatibility complex: a journey academic.oup.com/jleukbio/adv...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

Spatial Constraints Limit NK Cell Access to Germinal Center HIV Reservoirs in Lymph Nodes academic.oup.com/jid/advance-...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

Age-related changes of FCGR3A+ NK cells and their association with elderly atopic dermatitis www.sciencedirect.com/science/arti...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

Review @frontiersin.bsky.social ILC plasticity in intestinal immune barrier remodeling www.frontiersin.org/journals/imm...

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social KMT2D promotes NK cell effector molecule release www.biorxiv.org/content/10.6... @katekazane.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@biorxivpreprint.bsky.social Single-cell multi-ancestry regulatory map of systemic lupus erythematosus www.biorxiv.org/content/10.6... @sangerinstitute.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 28/09/2026

@medrxivpreprint.bsky.social Decidual-Like NK Cells Are Enriched in Melanomas and Acquire CD9 Through Melanoma Cell Contact www.medrxiv.org/content/10.6... @pn0rmski.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Circulating tumor cells produce tumor-antigen enriched migrasomes during vascular migration that are captured efficiently by antigen-presenting cells in secondary lymphoid organs that cross-present to CD8 T cells www.nature.com/articles/s41... @natimmunol.nature.com

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

The IRF8-CCL8-CCR5 axis as an epigenetically potentiated nexus of innate and adaptive antitumor immunity @natcomms.nature.com www.nature.com/articles/s41...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Canonical Notch2 signaling regulates development and maintenance of iron-recycling macrophages and iron homeostasis @natcomms.nature.com www.nature.com/articles/s41...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Elevated ozone activates maternal immunity to drive offspring IgG-mediated anaphylaxis through IgG glycosylation alterations www.nature.com/articles/s41... @natcomms.nature.com

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Pseudomonas aeruginosa induces the generation of pathogenic IFNγ+Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis www.nature.com/articles/s41... @natmicrobiol.nature.com

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease www.nature.com/articles/s41... @natgenet.nature.com

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Distinct effects of two different human interferon-alpha subtypes on indicators of T-cell proliferation, activation and inhibition @jimmunol.bsky.social @usask.ca academic.oup.com/jimmunol/art...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Prostaglandin D2 production in obese mice is associated with reduced lung inflammation and improved control of Francisella tularensis and Bordetella pertussis infection @jimmunol.bsky.social academic.oup.com/jimmunol/art...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

T-cell responses shape infant SIV reservoirs and post-intervention control following AAV9-eCD4-Ig and latency reversal @insight.jci.org @emoryuniversity.bsky.social insight.jci.org/articles/vie...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

IFN-γ–producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease @insight.jci.org insight.jci.org/articles/vie...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection @insight.jci.org @ohiostatemed.bsky.social insight.jci.org/articles/vie...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

An IL-18Rα+CXCR3+ subset enriched among early-life-derived CD8+ T cells with enhanced functional potential www.pnas.org/doi/10.1073/... @pnas.org @ox.ac.uk

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Selective ablation of dsDNA-specific plasma cells improves lupus nephritis in NZB/W mice @pnas.org www.pnas.org/doi/10.1073/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Splicing impairment reprograms the transcription start site of STING, switching its expression from an antiviral isoform to a nonantiviral variant that partially suppresses STING activity @pnas.org www.pnas.org/doi/10.1073/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Early-life enteric infection is a driver of long-lasting neuroimmune imbalance @pnas.org @gareaulab.bsky.social @ucdavis.bsky.social www.pnas.org/doi/10.1073/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Review @jem.org @changsbrain.bsky.social Vagal neuroimmune circuits in inflammation and immunity rupress.org/jem/article/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Long-lived naive CD8 T cells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors @jem.org rupress.org/jem/article/... rupress.org/jem/article/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Neutrophils adopt a tissue-adapted state at the early maternal-fetal interface that supports trophoblast invasion www.science.org/doi/10.1126/... @sciimmunology.bsky.social @annaleukin10.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Nanobodies targeting MR1-antigen complexes are engineered to modulate mucosal-associated invariant T cells and target MR1-ligand complexes on tumors www.science.org/doi/10.1126/... @sciimmunology.bsky.social @thedohertyinst.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

A systematic repurposing pipeline identified uterus-selective tocolytics with efficacy in human myometrium and preclinical models www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Oral danegaptide prevents inner blood-retina–barrier breakdown in animal models of retinal vascular disease and is safe in patients www.science.org/doi/10.1126/... @tcddublin.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

The CXCL1-CXCR2 axis is an actionable therapeutic target in leptomeningeal metastasis and enhances response to craniospinal irradiation www.science.org/doi/10.1126/... @mskcancercenter.bsky.social @adrienneboire.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Nucleoside analogs show protective and therapeutic effects in a mouse model of multiple sclerosis and reduced risk in humans www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

In photosensitive lupus, dysregulated cutaneous UV responses recruit and activate monocyte-derived dendritic cells that may drive lesion development www.science.org/doi/10.1126/... @kahlenberglab.bsky.social @umichmedicalschool.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

A plasma membrane adaptor protein supports cytotoxic T cell function by connecting with the actin network www.science.org/doi/10.1126/... @columbiauniversity.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Airway epithelia clear rhinovirus infection via two waves of cell extrusion www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

An RNF43659 mutation is enriched in microsatellite instability–high colorectal tumors mediates PI3K/AKT activation induced HLA-E expression, suppressing NK cell function www.science.org/doi/10.1126/... @danafarber.bsky.social @broadinstitute.org @harvardmed.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 27/09/2026

Positivity bias skews the scientific record by favoring positive results: Ensuring integrity in scientific research www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 26/09/2026

Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates @science.org www.science.org/doi/10.1126/...

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Waggoner Lab @labwaggoner.bsky.social · 26/09/2026

The AR-Gβγ signaling axis therefore represents a druggable target for cardiac fibrosis www.science.org/doi/10.1126/... @science.org @stanforduniversity.bsky.social

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Waggoner Lab @labwaggoner.bsky.social · 26/09/2026

Exposure to high dietary fat increases ceramides and promotes cancer metastasis @science.org @einsteinmededu.bsky.social @danafarber.bsky.social www.science.org/doi/10.1126/...

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