Highlighting how chromatin organisation, nuclear architecture, gene regulatory networks, metabolism and RNA-based mechanisms converge to shape cell identity and plasticity across development, homeosta...

The authors use tree shrews in multispecies comparisons to identify evolutionary changes in CCNB1IP1 expression associated with primate cortical expansion and folding, and investigate the cis-regulato...

This study provides a single-cell RNA-sequencing atlas of 77 healthy and chronic liver disease livers and identifies a subpopulation of pro-inflammatory scar-associated macrophages enriched for OLR1 e...

The authors show that platinum is a greater driver of DNA damage response gene-mutant clonal hematopoiesis than poly(ADP-ribose) polymerase inhibitors and that the presence of germline mutations confe...

This study uses single-cell ATAC–seq to map chromatin accessibility in the intestinal mucosa from patients with Crohn’s disease and healthy controls to characterize regulatory programs associated with...

Genome-wide analyses identify common and rare variants associated with childhood adiposity, including rare protein-coding variants in ADCY3, CALCR, MC4R, MRAP2, POMC and MYH13 that exhibit stronger ef...

Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...

Single-cell transcriptomics, spatial transcriptomics and chromatin accessibility maps of the human craniofacial region in developing embryos provide insights into the mechanisms underlying facial vari...

Epigenomic analyses of medulloblastoma identify a bivalent/poised enhancer (EnhBiv) chromatin signature enriched for KDM2B binding in Group 3 and Group 4 tumors. Functional work suggests a selective d...

Deep phenotyping can improve diagnostic precision in psychiatric genomics, but it remains susceptible to non-random, partly heritable selection bias that compromises representativeness. Accordingly, a...

Genetic factor analysis uses genome-wide association summary statistics to identify shared polygenic factors underlying patterns of cross-trait genetic associations, while automatically determining th...

Gb3 encodes an intracellular kinase–pseudokinase protein with a unique MAP3K-like domain that confers resistance to multiple greenbug biotypes in wheat.

Multi-resolution genetic regulatory atlas of the human brain from single-nucleus transcriptomics of 1,384 donors of diverse ancestries reveals cell type-specific regulation underlying genetic risk of ...

This Perspective discusses computational structural genomics, a conceptual framework that links genetic variants to three-dimensional molecular structures and their dynamics and function in a cellular...

This study uses budding yeast as a model system to link genetic variants with quantitative changes in protein–protein interaction strength under different environmental perturbations by leveraging a p...

Pan-genome analyses of cultivated peanut using 10 newly assembled genomes, along with whole-genome resequencing of 2,320 germplasm accessions, highlight structural variations and loci associated with ...

Single-cell multiomics of blood stem cells from patients with myeloproliferative neoplasms revealed that interferon-α normalizes blood counts by augmenting lymphoid differentiation and modulates clona...

Genomic analyses in populations of East Asian ancestry identify rare copy number variants associated with schizophrenia. Meta-analyses with populations of European ancestry identify additional risk lo...

Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...

Genome-wide analyses in up to 121,579 pregnant women from China identify genetic associations across 111 phenotypes, including gestation-specific effects and interactions with gestational timing.

Intrinsically disordered regions impose regulatory restraints on gene-activating demethylases, limiting chromatin engagement and preserving genomic stability. This function is a key determinant of the...

Pangenome analyses of chromosome-scale genome assemblies for 125 diverse cucumber accessions highlight structural variation shaped by selection for geographical adaptation, fruit-length diversificatio...

This study uses a highly selective inhibitor to elucidate DNMT1’s specific functions and their regulation. Notably, RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promo...

By inserting diverse promoters at the mouse Sox2 locus, Koska et al. show that promoter strength, position and transcript length tune promoter competition through transcription-dependent insulation, i...

Genome-wide association analyses identify risk variants for borderline personality disorder and find genetic correlations with psychiatric disorders, behavioral traits and somatic diseases.

Analyses in prostate cancer cell lines show that FOXA1 mediates tissue-specific recruitment of NIPBL to chromatin to orchestrate three-dimensional genome organization, acting in concert with ETS1 and ...

We show that, in a genomic locus with minimal complexity, the distance between promoter and enhancer modulates the frequency of clustered transcriptional bursts. Thus, besides the nucleotide sequence,...

The authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differenti...

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

The study integrates cross-species single-cell and genomic analyses with functional validations to map the endosteal bone compartment, revealing musculoskeletal-disease-relevant cell types and transcr...

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

Job Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...

INSPIRE addresses challenges to integrating diverse spatial transcriptomics datasets by combining deep learning with non-negative matrix factorization, revealing shared and context-specific spatial ge...

Profiling of pleural mesothelioma samples from 91 patients identifies four DNA methylation subtypes that correlate with response to immune checkpoint inhibition and survival

Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explore...

Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.

CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.

Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse populations.

Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate T cell gene expression and proliferation.

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that high...

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Multiancestry fine-mapping of brain protein quantitative trait loci coupled with Mendelian randomization analyses identifies protein–trait pairs consistent with causal effects across neurological and ...