Sign in

Eric Topol

@erictopol.bsky.social
194K followers 309 following 3.4K posts

physician-scientist, author, editor www.scripps.edu/faculty/topol Ground Truths erictopol.substack.com SUPER AGERS www.simonandschuster.com/books/Supe…

PostsRepliesMedia
Eric Topol @erictopol.bsky.social · 16h
Why do our cells age? It's not just wear and tear, accumulated damage. Loss of cell identity takes center stage. A new Nature paper and connection with prior work that substantially advances the science of aging. In the new Ground Truths. erictopol.substack.com/p/loss-of-ce...
erictopol.substack.com
Loss of Cell Identity Drives Human Aging
That’s What Biological (Epigenetic) Aging Clocks Are Measuring
716346
Eric Topol @erictopol.bsky.social · 30/09/2026
Exercise slowed epigenetic aging again. This time in a randomized controlled trial among breast cancer survivors. academic.oup.com/jnci/advance...
219640
Eric Topol @erictopol.bsky.social · 28/09/2026
Measles: What is likely going to happen in Florida (and much of the US) as MMR vaccination has dropped below the threshold needed to prevent outbreaks? Hundreds of deaths in the next 5 years projected throughout the US. www.pnas.org/doi/full/10....
10175108
Eric Topol @erictopol.bsky.social · 27/09/2026
The word of the day: Zombified www.nytimes.com/2026/09/26/h...
711233
Eric Topol @erictopol.bsky.social · 21/09/2026
How forever chemicals (PFAS) block our immune response to viruses www.pnas.org/doi/full/10....
415872
Eric Topol @erictopol.bsky.social · 20/09/2026
The irony of it all Yesterday, @NEJM posted a new essay suggesting that the US government attacks on biomedical science will subside. www.nejm.org/doi/full/10.... On the same day, it was announced the President wants control of NIH funding
13278120
Eric Topol @erictopol.bsky.social · 19/09/2026
Your wearable or mattress sensor is giving you your HRV and a "Readiness" score every day? What are these metrics and do they have value? erictopol.substack.com/p/the-big-ho...
erictopol.substack.com
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
A Gaping Lack of Evidence for Health Benefits
1114730
Eric Topol @erictopol.bsky.social · 17/09/2026
A brilliant new @nature.com synthesis of what we know about Alzheimer's disease pathogenesis, which is non-linear, with discrete phases (Figure), and notable inflection and transition points. Also helps to explain why symptoms do not correlate with underlying pathology. nature.com/articles/s41...
215645
Eric Topol @erictopol.bsky.social · 11/09/2026
Most supplements and vitamins have little or no proven benefit, and even some have potential of harm, but that hasn't held back ~80% Americans taking them, highest proportion ever www.nytimes.com/2026/09/11/w...
nytimes.com
Supplements Are More Popular Than Ever (Gift Article)
A new survey found that 8 in 10 Americans were taking vitamins, protein powders or other supplements. But experts said many offer little to no benefit.
1214860
Eric Topol @erictopol.bsky.social · 11/09/2026
Here's your supplement and vitamin pairing for today! pewresearch.org/short-reads/... @pewresearch.org gift link @washingtonpost.com wapo.st/4A6QyjF
610523
Eric Topol @erictopol.bsky.social · 10/09/2026
Prior to cancer immunotherapy, vaccination of any kind, not only mRNA Covid (as previously reported), is associated with a small and transient (~6 months) benefit of improved survival www.nature.com/articles/s41...
216542
Eric Topol @erictopol.bsky.social · 09/09/2026
Marked benefit of Covid updated or booster vaccination in people with autoimmune conditions Real world evidence for over 60,000 individuals with major (40-70%) reduction of hospitalization acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com
Updated <fc>COVID</fc>‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions
Objective We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECM...
321788
Eric Topol @erictopol.bsky.social · 07/09/2026
We have traditionally provided reassurance to patients with a borderline anemia. This new prospective data from >500,000 people challenges that lack of concern, indicating an increased risk of all-cause mortality www.acpjournals.org/doi/10.7326/... @annalsofim.bsky.social
213235
Eric Topol @erictopol.bsky.social · 07/09/2026
Sickening.
822077
Eric Topol @erictopol.bsky.social · 05/09/2026
On the wellness industry BS. "I Need A Drip to Recover From My IV Drip" gift link nytimes.com/2026/09/02/m... Now a $3 billion market for IV drips!
nytimes.com
I Need an IV Drip to Recover From My IV Drip (Gift Article)
Wellness clinics are shooting people up with vitamins, but is the point to actually feel better — or the opposite?
48719
Eric Topol @erictopol.bsky.social · 05/09/2026
Why did 2 large, pivotal clinical trials [vs interleukin-6 and Lp(a)] fail to lower heart attacks, strokes and cardiovascular deaths? erictopol.substack.com/p/the-corona...
erictopol.substack.com
The Coronary Artery Inflammation Controversy
How Two Large Outcome Trials Based on Surrogate Metrics Failed
09119
Eric Topol @erictopol.bsky.social · 04/09/2026
Why have antioxidant supplements not helped reduce the incidence of cancer and in some trials shown an increase? Suppression of T cell immune response to cancer @ScienceMagazine science.org/doi/10.1126/... science.org/doi/10.1126/...
310636
Eric Topol @erictopol.bsky.social · 03/09/2026
This new report questions the previous one that found a survival benefit specifically conferred to mRNA Covid vaccine before cancer immunotherapy. Similar benefit was also seen with the J&J adenovirus Covid and flu vaccines www.pnas.org/doi/epdf/10....
110212
Eric Topol @erictopol.bsky.social · 02/09/2026
What is being done vs #LongCovid and other post-viral serious chronic illness? Not enough. www.nature.com/articles/d41...
nature.com
When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes
Hundreds of millions of people have long-term conditions as a result of an infection. Researchers are working out how to help them.
6255106
Eric Topol @erictopol.bsky.social · 01/09/2026
Ovarian aging and the "leaky gut" "These findings provide the strongest evidence to date that menopause may promote gut barrier dysfunction and microbial translocation in otherwise-healthy women." jci.org/articles/vie...
613345
Reposted by Eric Topol
PLOS Medicine @plosmedicine.org · 01/09/2026
In this Perspective, Anja Schmidt and colleagues (@erictopol.bsky.social) discuss how #openaccess options for publishing commercially-funded research are often restricted, examine the consequences of this inequity, and argue for funder-neutral #publishing policies🧪📑🔐 #MedSky plos.io/4ioSRbB
plos.io
Enabling equitable open access to commercially funded research publications
In this Perspective, Christopher Winchester and colleagues discuss how open access options for publishing commercially-funded research are often restricted, examine the consequences of this inequity, ...
0238
Eric Topol @erictopol.bsky.social · 31/08/2026
On #LongCovid and profiling my colleague @julialmv.bsky.social @smithsonianmag.bsky.social www.smithsonianmag.com/innovation/m...
smithsonianmag.com
For Many Americans, Covid Is Still a Chronic, Disabling Disease. These Scientists Are Working Tirelessly to Bring Them Relief
Long Covid saps the strength and vitality of patients, who have little recourse to fight it. A team of specialists—including an afflicted researcher working mostly from her bed—is looking for answers
6257128
Reposted by Eric Topol
Paula Dunn @kenaiseasky.bsky.social · 31/08/2026
substack.com/profile/1280...
substack.com
Julia Belk (@juliabelk)
here are the papers! https://www.nature.com/articles/s41586-026-10939-0 https://www.science.org/doi/10.1126/science.adt8307
0113
Eric Topol @erictopol.bsky.social · 31/08/2026
One of the most important discoveries about our brain in many years! erictopol.substack.com/p/two-landma...
erictopol.substack.com
Two Landmark Studies Challenge Dogma About our Brain Immune Cells and Aging
Lead Authors Julia Belk and Nathan Zemke Discuss and Translate their Findings
418055
Eric Topol @erictopol.bsky.social · 28/08/2026
We need to rev it up. Cancer vaccines. nature.com/articles/d41... @nature.com
421560
Eric Topol @erictopol.bsky.social · 28/08/2026
Self-directed antibodies are found in people with #LongCovid. A key source of these was identified, and these autoantibodies and cell origin are also seen in lupus. @cp-immunity.bsky.social www.cell.com/immunity/ful...
422390
Eric Topol @erictopol.bsky.social · 27/08/2026
Good news www.nytimes.com/2026/08/27/w...
nytimes.com
What to Know About New Covid Vaccines for Fall 2026
The shots have been approved for people 65 and older, and for younger people with underlying conditions. Others may be able to get them off label.
720958
Eric Topol @erictopol.bsky.social · 26/08/2026
New insights for vaccinology, a field that is accelerating our understanding of the human immune system, with the help of AI. Reviewed @nature.com nature.com/articles/s41...
510525
Eric Topol @erictopol.bsky.social · 26/08/2026
The US, a Nation of Needles Some of these injections are well validated; others, such as unregulated peptides (some promoting longevity) have no meaningful human data but pushed through to unbanned status by RFK Jr Front page @nytimes.com today gift link nytimes.com/2026/08/17/w...
nytimes.com
Welcome to Needle Nation (Gift Article)
Weight-loss drugs, peptides, I.V.F. As sharps migrate out of doctors’ offices, even needle-phobics are willing to embrace shots.
39528
Eric Topol @erictopol.bsky.social · 26/08/2026
Calcium scans of the heart arteries, one of the most frequently ordered tests by primary care physicians and cardiologists, have little incremental value compared with well-established clinical risk scores. t.co/l6MwSpd0OB
19719
Eric Topol @erictopol.bsky.social · 26/08/2026
More validation for how critical health of the thymus is in adults, as assessed by AI of a chest CT. Thymus radiation exposure is linked to worse outcomes for cancer (non-small cell lung cancer) for distant metastasis and reduced survival annalsofoncology.org/article/S092...
annalsofoncology.org
Thymic radiation is associated with worse outcomes in patients with NSCLC
Emerging evidence indicates the functional importance of the thymus in adult health and may influence oncological outcomes, yet current radiotherapy (RT) practice does not consider the thymus as an or...
29525
Eric Topol @erictopol.bsky.social · 24/08/2026
On AI curing all diseases theinformation.com/articles/ai-...
theinformation.com
Why Scientists See AI Leaders as False Prophets
Eric Topol is a prominent cardiologist known for his research into deploying AI and other technologies to improve healthcare. He considers himself a Demis Hassabis superfan, and when I spoke to him, h...
712745
Eric Topol @erictopol.bsky.social · 24/08/2026
Good review on Postural Orthostatic Tachycardia Syndrome (POTS) today @jama.com jamanetwork.com/journals/jam...
616858
Reposted by Eric Topol
David Shaywitz @dshaywitz.bsky.social · 24/08/2026
Most intrstng aspect of @erictopol.bsky.social's new pcast w @debscohen.bsky.social =insight into pervasiveness of influencer cx on health/wellness: podcasts.apple.com/us/podcast/d... .Less ideal=strong suggestion that "prevention" generally $-driven scam vs potentially rational approach to health.
podcasts.apple.com
Deborah Cohen: The Wellness-Industrial Complex
Podcast Episode · Ground Truths · August 23 · 59m
0166
Eric Topol @erictopol.bsky.social · 23/08/2026
Deconstructing the wellness-industrial complex and how to defend against it erictopol.substack.com/p/deborah-co...
erictopol.substack.com
Deborah Cohen: The Wellness-Industrial Complex
The Sick Until Proven Healthy Trap
211239
Eric Topol @erictopol.bsky.social · 22/08/2026
www.economist.com/united-state...
economist.com
The real covid-19 scandal is still unfolding
The failure to reckon with lives needlessly lost will make the next pandemic deadlier
414237
Eric Topol @erictopol.bsky.social · 21/08/2026
Happy 117th! www.goodmorningamerica.com/living/story...
315614
Eric Topol @erictopol.bsky.social · 21/08/2026
Where we're headed......
917962
Eric Topol @erictopol.bsky.social · 20/08/2026
Why do some people have a robust response to vaccines and others are blunted? Sentinel antibodies www.sciencedirect.com/science/arti...
211122
Eric Topol @erictopol.bsky.social · 19/08/2026
mRNA vaccines vs cancer success —melanoma (Phase 3, RCT, definitive, announced today) —triple negative breast cancer —pancreatic cancer —non-small cell lung cancer —glioblastoma
8534171044
Eric Topol @erictopol.bsky.social · 18/08/2026
Enough of the cure talk. Where are the cures for these diseases?
1928044
Eric Topol @erictopol.bsky.social · 18/08/2026
The dangers of RFK Jr's peptide push Example: "If you have a few precancerous cells lurking indolently in your prostate or breast, injecting a peptide that stimulates human growth hormone might supercharge them into a tumor." gift link wapo.st/4wycy3O
13227118
Eric Topol @erictopol.bsky.social · 17/08/2026
The cancer mortality hazard among pilots and flight attendants. An analysis of 503 occupations, including ground-based aviation workers and nuclear technologists, found that pilot and flight attendants had the highest proportion of radiation-related cancer deaths jamanetwork.com/journals/jam...
614856
Eric Topol @erictopol.bsky.social · 16/08/2026
I'm keen on AI having a transformational impact on human health. But these cure projections are wildly off-base and impossible.
1215024
Eric Topol @erictopol.bsky.social · 16/08/2026
Surprised by this endorsement by The Economist for these companies selecting embryos for up to $50K, "designer-ish babies," whose IQ, height & other features, can supposedly be accurately predicted by polygenic risk scores. They can't. economist.com/leaders/2026... www.economist.com/business/202...
713832
Eric Topol @erictopol.bsky.social · 14/08/2026
How to delay ovary aging? —Exercise —And the potential of targeting adiponectin receptor From 2 large cohorts ~165K participants and extensive studies in mice nature.com/articles/s43...
nature.com
Physical activity delays ovarian aging in part through adiponectin-related signaling pathways - Nature Aging
Physical activity has geroprotective properties, yet its role in ovarian aging is incompletely understood. Here, a cross-sectional analysis of human cohorts links lower physical activity with menopaus...
17824
Eric Topol @erictopol.bsky.social · 13/08/2026
"government overreach designed to disconnect citizens from the truth and advance an authoritarian agenda" "must recognize how critically linked science is to democracy itself and defend its integrity with every tool at their disposal." @science.org www.science.org/doi/10.1126/...
218873
Eric Topol @erictopol.bsky.social · 13/08/2026
Our understanding how our brain ages and why our memory begins to slip around age 50 have been completely revamped through 2 new landmark studies involving the microglia, the brain immune cells erictopol.substack.com/p/why-our-me...
erictopol.substack.com
Why Our Memory Slips After Age 50
Landmark independent studies challenge longstanding dogma for brain aging
821457
Eric Topol @erictopol.bsky.social · 11/08/2026
Stop the hype on anti-aging treatments such as NAD+ and peptides. Get the evidence. Editorial @naturemedicine.bsky.social nature.com/articles/s41...
417248
Eric Topol @erictopol.bsky.social · 11/08/2026
Vaccine benefit in children "Since 1974, vaccination has averted 154 million deaths, including 146 million among children younger than 5 years of whom 101 million were infants younger than 1 year." www.thelancet.com/journals/lan... The most striking benefit was for vaccination vs measles (Figure)
151052530