Sevabertinib, a non-covalent inhibitor of the HER2 kinase, shows activity in preclinical cancer models with genomic activation of ERBB2 and for patients with HER2-mutant lung cancer.

AbstractHigh-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fat...

Abstract. Clonal hematopoiesis (CH) — the expansion of genetic variants in blood — is a prime example of somatic evolution. Although it often precedes malignant transformation, many aspects of this pr...