iiinova — where your digital self keeps evolving

Reposted by Michelle Frei

Max Perutz Labs Vienna @maxperutzlabs.ac.at · 30/09/2026

Exciting news for the Perutz: @mschuhmacher.bsky.social will join the institute as a new group leader in 2027! 🎉 Currently leading an independent group at EPFL Lausanne, Milena brings an innovative chemical biology approach to lipid research ➡️ tinyurl.com/4x9xm24m

4309

Reposted by Michelle Frei

Heilemann Lab @heilemannlab.bsky.social · 17/08/2026

🚨 2x PhD opportunities: single-molecule/super-resolution microscopy & image analysis of membrane proteins 🔬(DM for details) 👉🏻 tinyurl.com/5dt7ncby 👉🏻 tinyurl.com/5e52dth2 🙏 Dear colleagues & friends, pls distribute - Thank you! 🙏 @crc1507.bsky.social imol.uni-frankfurt.de @goetheuni.bsky.social

02217

Reposted by Michelle Frei

Juliette Griffié @juliettegriffie.bsky.social · 17/07/2026

We're thrilled to unveil our fantastic line-up of selected speakers for SMLMS 2026 at smlms.org Huge congratulations to them! 🎉 Missed the deadline? Good news! Registration and poster abstract submission have been extended until 31st July! 🔬✨

smlms.org

SMLMS 2026 – Stockholm

0114

Reposted by Michelle Frei

Richard Lincoln, PhD @rlincolnchemist.bsky.social · 15/07/2026

📢 I'm thrilled to announce that I'll be joining the HHMI Janelia Research Campus as a Group Leader in MTI! It's an honor to be part of Janelia's Next Chapter, pushing dye development and imaging technologies into new dimensions. The Lincoln Lab launches Sept. 14th, stay tuned for more info! 🔬⚗️👨🏼‍🔬

2324

Reposted by Michelle Frei

Katherine Copsey @katcopseygreens.bsky.social · 08/07/2026

Gather round for the story of the Very Hungry Data Centre... 🧵 (1/4) #datacentre #ai

A parody of the Very Hungry Caterpillar by Eric Carle. Text reads "The Very Hungry Data Centre" and the image shows a large black-and-brown shape, like a rounded rectangle with the top divided into three 'towers', with a smiling face reminiscent of the Very Hungry Caterpillar in the middle - red with yellow and green eyes.

Text reads "One Sunday morning the warm sun came up and - pop! - out of nowhere came a very hungry data centre."

Image shows the VHDC on brown ground with the orange sun rising.

Text reads "On Monday he drank a quarter of the city's annual drinking water."
Image shows a blue shape, with a circle cut out of the middle, reminiscent of the foods with circles cut out in the Very Hungry Caterpillar.

Text reads "On Tuesday he ate so much that he doubled demand on the country's power-grid.
So he opened a new gas plant, just for him."
Image shows two yellow spiky shapes representing electricity, also with circles cut out of them.

3174101

Reposted by Michelle Frei

Pedro Beltrao @pedrobeltrao.bsky.social · 06/07/2026

My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...

nature.com

Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386

The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

07683

Reposted by Michelle Frei

Addgene @addgene.bsky.social · 13/05/2026

New plasmids from Kai Johnsson now online! 💡 The self-labeling CLIP-tag2 achieves almost 1000-fold faster tagging than the original when combined with a new substrate optimized for live-cell imaging. twp.ai/4hrKYy

087

Reposted by Michelle Frei

Stephan Hacker @stephanhacker2.bsky.social · 24/04/2026

We are again looking for 3 Flash Talks for the 6th Virtual @chembiotalks.bsky.social. If you are a PhD candidate or postdoc in the field of #ChemBio, I strongly encourage you to apply via our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/... #ChemBio #ChemSky #Competition

064

Reposted by Michelle Frei

Virtual ChemBioTalks @chembiotalks.bsky.social · 23/04/2026

Are you a #PhD candidate or #postdoc and do you want to present your #ChemBio research to a large audience? Here is your chance. You can apply through our abstract challenge to present at the 6th Virtual ChemBioTalks on September 29th. chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

042

Reposted by Michelle Frei

Amy Diehl, Ph.D. @amydiehl.bsky.social · 23/04/2026

In 1915, Gillette began convincing women that leg & armpit hair were embarrassing, masculine & unhygienic--to sell razors. A norm that has no health benefits but incredible compliance. Women are called 'disgusting' when they have the same body hair as men. www.thepersistent.com/tangled-hist...

thepersistent.com

The Tangled History of Women and Body Hair

Is it time, finally, to push back?

03310

Reposted by Michelle Frei

Deliz Liang lab @lab-adl.bsky.social · 19/02/2026

Still obsessed with histidine (and its mimics)! Our latest work from Benjamin 🎉 uses genetic code expansion—tuning the primary coordination sphere of a dizinc metallohydrolase—lowering the catalytic pKa and boosting activity up to 5x at acidic pH. Check it out! doi.org/10.1021/acs.biochem.5c00768

doi.org

Catalytic pKa Attenuation in a Hydrolytic Metalloenzyme by Genetic Code Expansion

Hydrolytic metalloenzymes employ Lewis-acidic metal cofactors to activate water molecules, generating nucleophilic hydroxide species that facilitate catalysis. Their catalytic efficiency across a wide...

086

Michelle Frei @michellefrei17.bsky.social · 14/02/2026

🚨 Are you in need of a sensitive ratiometric protein kinase A (PKA) biosensor? 🚨 We got you covered: far-red, large changes, rapid response kinetics, selective! Anything you could wish for. Check out these two preprints from the Zhang Lab 🧪 🧑‍🔬 Congrats to everyone involved!

091

Reposted by Michelle Frei

Mar Hicks @histoftech.bsky.social · 06/02/2026

No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition. Which just makes me want to share it again: www.nature.com/articles/d41...

nature.com

Gladys Mae West obituary: mathematician who pioneered GPS technology

She made key contributions to US cold-war science despite facing huge barriers as a Black woman.

13674820319711

Michelle Frei @michellefrei17.bsky.social · 27/11/2025

🚨How do we implement synthetic fluorophores into biosensors? Have a look at Elias Dressler’s review article in Chimia. The issue highlights the work of Young Professors and Ambizione Fellows in Switzerland. Glad to be part of this vibrant community. ⚗️ www.chimia.ch/chimia/artic...

092

Reposted by Michelle Frei

Nature Chemical Biology @natchembio.nature.com · 04/11/2025

A new Review by Agnese Nicoli and Michelle Frei examines the progress in developing synthetic small-molecule fluorophores and how these in combination with innovative labeling strategies can advance chemical biology www.nature.com/articles/s41...

nature.com

Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology

Performing live-cell microscopy experiments with high spatial and temporal resolution requires fluorophores with highly optimized properties. This Review examines the progress in developing synthetic ...

0132

Michelle Frei @michellefrei17.bsky.social · 05/11/2025

🚨Curious how synthetic fluorophores simplify microscopy? Our review covers applications such as super-resolution microscopy and biosensing. 🎉👩‍🔬Congrats to my first PhD student, Agnese Nicoli, for the fearless deep dive! 🔬 ⚗️ D-CHAB @ethz.ch www.nature.com/articles/s41...

nature.com

Synthetic fluorophores for live-cell fluorescence microscopy and biosensing - Nature Chemical Biology

05320

Reposted by Michelle Frei

Kathrin Lang @klanglab.bsky.social · 16/10/2025

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

nature.com

Hijacking a bacterial ABC transporter for genetic code expansion - Nature

Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...

2021660

Reposted by Michelle Frei

GdR ImaBio 🔬 @gdrimabio.bsky.social · 04/10/2025

#Mifobio2025 Focus on the module 1 : 👉 "Marking strategies at different scales of life" We are delighted to welcome @michellefrei17.bsky.social @ethz.ch Lecture : "Chemigenetic kinase biosensors for multiplexed activity sensing and super-resolution imaging" 👉 imabio-cnrs.fr/mifobio-2025/

095

Reposted by Michelle Frei

Virtual ChemBioTalks @chembiotalks.bsky.social · 23/09/2025

The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social. Make sure to register for free: web.cvent.com/event/... #ChemSky #ChemBio

097

Reposted by Michelle Frei

hilzoy @hilzoy.bsky.social · 04/08/2025

This is a really, really important story, which is why I provided a gift link. Many people, when they think of higher education, think of elite universities. But most higher education is nonselective (i.e., they admit everyone), and a lot of it is community colleges.

7585276

Reposted by Michelle Frei

Florian Schueder @florianschueder.bsky.social · 31/07/2025

🚨 2 × PhD positions @EPFL! 🚨 Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch #PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

12320

Reposted by Michelle Frei

Sonja Schmid @scisonja.bsky.social · 31/07/2025

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch

schmid.chemie.unibas.ch

Home | Research Group Schmid | University of Basel

23633

Reposted by Michelle Frei

Tom Fiala @tomfialab.bsky.social · 21/07/2025

We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. www.fialalab.com Appreciate sharing!

0106

Reposted by Michelle Frei

Kai Johnsson @kjohnsson.bsky.social · 09/07/2025

Teaching an old bacterial protein new tricks: Fast, bright and reversible rhodamine tags for live-cell imaging: www.biorxiv.org/content/10.1... Congratulations to Julian Kompa and the entire team.

biorxiv.org

Fast, Bright and Reversible Rhodamine Tags for Live-Cell Imaging

We present Rho-tag and SiR-tag, engineered protein tags derived from bacterial multidrug-resistance proteins that bind unsubstituted (silicon-) rhodamines with nanomolar affinity, enabling fast, rever...

05122

Reposted by Michelle Frei

Max Planck Institute for Medical Research @mpi-mr.bsky.social · 03/07/2025

📣Paper alert! Interested in faster and brighter protein labeling than before? 👀 @steffi-k.bsky.social & other colleagues have developed an improved tool for labeling proteins with synthetic fluorophores for bioimaging. Also works in STED microscopy 🤩🔬 Congratulations!🥳 www.nature.com/articles/s41...

nature.com

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

03915

Reposted by Michelle Frei

Nathalie M. Grob @nathalie-grob.bsky.social · 10/06/2025

We are hiring! Check out our open PhD position for an exciting industry collaboration with Novo Nordisk: jobs.ethz.ch/job/view/JOP...

jobs.ethz.ch

PhD Position in Peptide-Based Drug Discovery (Industry Collaboration, w/m/d)

0127

Reposted by Michelle Frei

GdR ImaBio 🔬 @gdrimabio.bsky.social · 19/05/2025

🔥 We've already received over a third of pre-registrations! #Mifobio2025 is already shaping up to be a highly attractive event... Don't delay in pre-registering! 👉 imabio-cnrs.fr @cnrs.fr @cnrsbiologie.bsky.social @cnrsingenierie.bsky.social @cnrs-inist.bsky.social

01211

Michelle Frei @michellefrei17.bsky.social · 01/05/2025

Want to be part of the 5th Virtual ChemBio Talks? Submit you abstract until 📅 June 30th. Two amazing keynote speakers @oconnorlab.bsky.social and @craigmcrews.bsky.social are already confirmed. More coming soon. Stay tuned! ⚗️👩‍🔬🦠🧑‍🔬

0105

Michelle Frei @michellefrei17.bsky.social · 21/04/2025

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

nature.com

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

88823

Michelle Frei @michellefrei17.bsky.social · 08/04/2025

My lab at @ethzurich.bsky.social is looking for a motivated PhD student. We develop chemical tools for advanced fluorescence microscopy 🔬 and work at the interface of synthetic chemistry ⚗️ and protein engineering 🦠. Sharing with skilled Master students appreciated. More info at tinyurl.com/2dbjk5ty

12418

Reposted by Michelle Frei

Virtual ChemBioTalks @chembiotalks.bsky.social · 02/04/2025

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards Marina Rubini @mlakemeyer.bsky.social @michellefrei17.bsky.social Hana Macíčková Cahová @drglycoben.bsky.social @borisvauzeilles.bsky.social @stephanhacker2.bsky.social (1/4) #ChemBio #ChemSky

1148

Reposted by Michelle Frei

Deliz Liang lab @lab-adl.bsky.social · 17/03/2025

🚨 PhD Opportunity! Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student! 🔬 Exciting interdisciplinary research 🤝 Engaging environment 🌱 📄 Does this sound like you, apply now! ⏳🔗 📢 Know someone? Share this! 🔄 jobs.uzh.ch/job-vacancie...

11011

Michelle Frei @michellefrei17.bsky.social · 12/02/2025

The Frei Research Group is growing! Excited to see how the projects of Mario, Agnese, and Elias will develop in the next months and years. Also grateful for the amazing admin support by Karin. ⚗️🔬👩‍🔬👨‍🔬

1131

Reposted by Michelle Frei

Tommaso Patriarchi @tpatriarchi.bsky.social · 10/02/2025

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!

178

Reposted by Michelle Frei

Kai Johnsson @kjohnsson.bsky.social · 07/02/2025

Check out our new fluorescent probe for imaging f-actin dynamics: 𝗦𝗶𝗥-𝗫𝗔𝗰𝘁𝗶𝗻: 𝗔 𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁 𝗽𝗿𝗼𝗯𝗲 𝗳𝗼𝗿 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹𝘀 www.biorxiv.org/content/10.1... Thank you @veselin-nasufovic.bsky.social

biorxiv.org

SiR-XActin: A fluorescent probe for imaging actin dynamics in live cells

Imaging actin-dependent processes in live cells is important for understanding numerous biological processes. However, currently used natural-product based fluorescent probes for actin filaments affec...

13912

Reposted by Michelle Frei

Jin Zhang Lab @jinzhanglab.bsky.social · 24/01/2025

Hello Bluesky! We're a UC San Diego-based lab that studies cellular signaling, and makes genetically encoded biosensors to study those signals. Talk to us about kinases, fluorescent proteins, GPCRs, and imaging technology!

4356

Reposted by Michelle Frei

Claire Deo @clairedeo.bsky.social · 07/01/2025

We made a photoswitchable HaloTag (psHaloTag), which can reversibly turn-on fluorogenic dyes upon illumination 💡. Congrats to Franzi, Bego and all co-authors, check out our preprint below 👇 www.biorxiv.org/content/10.1...

220852

Reposted by Michelle Frei

Anneliese Gest @ammgest.bsky.social · 14/11/2024

And what better introduction than to share a new publication? Check out this review article I’ve been working on (along with my co-first authors) if you need a biosensor or want a comprehensive overview of the field. Now out as an ASAP article at Chemical Reviews! doi.org/10.1021/acs....

doi.org

Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals

Cellular function is controlled through intricate networks of signals, which lead to the myriad pathways governing cell fate. Fluorescent biosensors have enabled the study of these signaling pathways ...

3195

Reposted by Michelle Frei

Falk Schneider @faldalf.bsky.social · 13/12/2024

‼️3 postdoc positions open‼️ We are building a quantitative imaging team at Warwick! Join an interdisciplinary endeavor with Mishima, Balasubramanian, and Mayor labs on a @wellcometrust.bsky.social funded project to push probe and microscopy development! warwick-careers.tal.net/vx/lang-en-G...

media.tenor.com

a logo that says let 's do this in blue and yellow

ALT: a logo that says let 's do this in blue and yellow

22621

Michelle Frei @michellefrei17.bsky.social · 05/12/2024

Curious what we do in my new lab at D-CHAB @ethzurich.bsky.social 🔬⚗️? Save the date for my inaugural lecture on April 3, 2025 and if you can’t wait to know more check out the news article and the associated video. chab.ethz.ch/en/news-and-...

person in front of microscope and microscopy image

0276

Reposted by Michelle Frei

Emmanuel Margeat @emmanuelmargeat.bsky.social · 21/11/2024

It is official! The fourth edidtion of our winter school on "Fluorescence markers for advanced microscopy" will take place on March 15-20 2026 in Les Houches, in the french Alps. fluorescenceleshouches.wordpress.com Selection of participants will start in 2025. Signup on the website to be informed.

36229

Reposted by Michelle Frei

Kathrin Lang @klanglab.bsky.social · 12/11/2024

🔈🔥! We have two open full professor positions at our institute (LOC) at ETH Zurich! 1. Synthetic Organic Chemistry 2. (Bio)analytical Chemistry Amazing students, staff, colleagues, infrastructure, location and long-term perspectives. 🫵 Apply and be our colleague!! ethz.ch/en/the-eth-z...

ethz.ch

Professor of Synthetic Organic Chemistry and Professor of (Bio)Analytical Chemistry

01315

Michelle Frei @michellefrei17.bsky.social · 13/02/2024

🚨Preprint alert 🚨Do you need a highly sensitive kinase biosensor? Want to multiplex multiple sensors or look at nanoscale activity architecture? Our far-red chemigenetic kinase biosensors are what you are looking for. Thanks to everyone involved! tinyurl.com/d36e2t4m

073

Michelle Frei @michellefrei17.bsky.social · 17/01/2024

The Frei Research Group will open its doors this summer @ethzurich.bsky.social! I am therefore looking for motivated PhD students to join me in developing chemistry inspired tools for advanced fluorescence microscopy. Please share with current master students 👩‍🔬🔬⚗️🧪👨‍🔬http://tinyurl.com/437xyu8n

0106