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Paul & Virginie - Centriole Lab

@centriolelab.bsky.social
2.4K followers 2.8K following 46 posts

Virginie Hamel & Paul Guichard Lab at University of Geneva #cryoEM/ET❄️ and #UExM ⚗️ #ExpansionMicroscopy #TeamTomo Genève, Suisse 🇨🇭 mocel.unige.ch/research-groups/guic…

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Reposted by Paul & Virginie - Centriole Lab
Mill_lab @cilialab.bsky.social · 24/09/2026
I’m wondering microscopy peeps whether it is time for an open letter to @healthcare.nikon.com head office about this #GenerativeAI creation- @reitergroup.bsky.social @christlet.bsky.social @simoncleary.bsky.social and community? (It’s blocked more tags sorry folks…)
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Reposted by Paul & Virginie - Centriole Lab
Simon Cleary @simoncleary.bsky.social · 23/09/2026
In the original version of this piece the person/people writing for the Nikon competition also removed a mention of AI by the winner:
Original paragraph reads:
'His advice to other researchers considering entering the competition is straightforward: “Take care of the sample, use as little light as possible when working with living cells, and most importantly, keep recording. The best moment usually appears right after you decide to stop.”'New paragraph has added section on AI: 'His advice to other researchers considering entering the competition is straightforward: “Take care of the sample, use as little light as possible when working with living cells, and embrace AI to reveal the hidden beauty in your data. Most importantly, keep recording. The best moment usually appears right after you decide to stop.”'
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Loïc A. Royer 💻🔬🧪 @loicaroyer.bsky.social · 23/09/2026
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
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Reposted by Paul & Virginie - Centriole Lab
Christophe 🔬 Leterrier @christlet.bsky.social · 22/09/2026
This is the updated part. Looks like the movie is an AI-generated fluorescence image from a non-labeled acquisition technique. No indication that the Small World jury and organizers have requested and verified the raw data (as mentioned as a possibility in the competition rules)
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Reposted by Paul & Virginie - Centriole Lab
Christophe 🔬 Leterrier @christlet.bsky.social · 22/09/2026
From the new info my bet is fluo labeling inference pushed to 11. Hallucinating nonsensical DAPI nuclei, mitochondria stain, membrane labeling from a kind of phase contrast image: wrong localization, wrong scale, wrong movement. Keeping this movie as SWiM winner is a disgrace to the competition
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Reposted by Paul & Virginie - Centriole Lab
Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 11/09/2026
Very proud of the team, led by @baukjeje.bsky.social & @fmikus.bsky.social To all of you doing #Expansion #Microscopy #UExM Try Concanavalin A. Its cheap, easy to use & labels the #nuclear #Envelope @moorefound.bsky.social @embl.org @sciencesunige.bsky.social @erc.europa.eu @snsf.ch
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Reposted by Paul & Virginie - Centriole Lab
Sachin Kotak @spindlebehavior.bsky.social · 15/09/2026
Can light build centrosome-like activity? 💡🔬 Yes! We introduce LISA (Light-Induced Spindle Assembly), now in @emboreports.org. By clustering Aurora A with optogenetics, we build centrosome-like activity that nucleates microtubules and rescues spindle defects after centrosome loss. shorturl.at/9h3VQ
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Reposted by Paul & Virginie - Centriole Lab
Haixia Zhou @haixia.bsky.social · 10/09/2026
First day here and I brought a paper. Three years of cryo-FIB-ET on human airway cells, nine proteins identified and two new PCD genes at the end of it. Grateful to the teams in Munster (Omran Lab), Boston (@alanbrownhms.bsky.social, Hawkins Lab) and Geneva (@centriolelab.bsky.social).
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Reposted by Paul & Virginie - Centriole Lab
Alan Brown @alanbrownhms.bsky.social · 10/09/2026
Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...
science.org
In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia
The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...
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Reposted by Paul & Virginie - Centriole Lab
Denis Chrétien @dchretien.bsky.social · 28/08/2026
Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)
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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 27/08/2026
Very happy to see our Nature Reviews Molecular Cell Biology Roadmap out! A fantastic collective effort, led by Carsten Janke and Zdenek Lansky, together with an amazing group of colleagues, and sparked by inspiring discussions at the Fondation des Treilles. www.nature.com/articles/s41...
nature.com
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease - Nature Reviews Molecular Cell Biology
Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...
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Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 25/08/2026
Pfttt so much manipulation. I wonder where these people went to school reeserichardson.blog/2026/08/25/a...
reeserichardson.blog
At least 15 companies are selling antibodies using faked validation data
Popular vendors’ catalogs feature more than 18,000 manipulated images
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Reposted by Paul & Virginie - Centriole Lab
Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 26/08/2026
And I wake up to my friend sending me this. I think this is the highlight of the probe. It’s just a cut and paste world doing WB…
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voigtvision.bsky.social @voigtvision.bsky.social · 12/08/2026
🚨 Now out in @aaas.org Science Advances 🚨: aDISCO: a protocol for clearing & antibody-staining human formalin-fixed paraffin-embedded (FFPE) tissue by Anna Maria Reuss! 🧠🔬#lightsheet #Microscopy @mesospim.bsky.social @ptrrupprecht.bsky.social www.science.org/doi/10.1126/...
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Reposted by Paul & Virginie - Centriole Lab
Marko Kaksonen @kaksonen.bsky.social · 11/08/2026
Endocytic clathrin coats are surprisingly dynamic: triskelia turn over in seconds. How is the turnover regulated and what is it for? Read Anne-Laure Boinet's preprint with @rouxlab.bsky.social www.biorxiv.org/content/10.6...
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Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · 11/08/2026
The GMI @gmivienna.bsky.social of the @oeaw.bsky.social seeks to appoint a Scientific Director (f/m/x) to lead one of Europe’s premier research institutes in plant biology. Apply by Nov. 15 via GMI.search.director@oeaw.ac.at. More information: www.oeaw.ac.at/de/gmi/join-...
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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 06/08/2026
Come join us at ETH!
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Reposted by Paul & Virginie - Centriole Lab
Journal of Cell Biology @jcb.org · 30/07/2026
Zhenjie Wang, Zhe Feng et al. uncover the molecular basis of Ana1-driven #centriole elongation in #Drosophila #spermatogenesis, showing that Ana1/CEP295 promotes longitudinal centriole extension through direct interactions with both Cep135 and #microtubules. rupress.org/jcb/article/...
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Stella Hurtley @smhsci.bsky.social · 31/07/2026
Out now in @science.org Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders | Science www.science.org/doi/10.1126/...
science.org
Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders
Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...
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Reposted by Paul & Virginie - Centriole Lab
EuroCilia2027 @eurocilia.bsky.social · 24/07/2026
📣 Abstract submission and early registration are now OPEN for the 7th European Cilia Conference—an official EMBO workshop! 📅 8–12 March 2027 📍 Stresa, Italy Submit and register: meetings.embo.org/event/27-cilia www.eurocilia.eu #EMBOCilia #Cilia2027
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Mike Dorrity @mwdorr.bsky.social · 23/07/2026
We’re accepting abstracts for QBMM, come join an excellent set of speakers, due early Sept
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Shicheng Guo @shihcheng.bsky.social · 21/07/2026
~50% of fertilized eggs arrest during human pre-implantation. Imaging 150+ embryos revealed error-prone 2nd mitotic divisions; centriole overduplication can be suppressed with PLK4 inhibitor. PMID:42276044, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-86… #Medsky #Pharmsky 🧪
cell.com
https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9
No description available
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Reposted by Paul & Virginie - Centriole Lab
Journal of Cell Biology @jcb.org · 20/07/2026
Michaud, @andrewgoryachev.bsky.social, von Dassow, @xenresearchcenter.bsky.social et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, & RGA-3/4 rupress.org/jcb/article/... 📕 In "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...
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Reposted by Paul & Virginie - Centriole Lab
Diez Lab @ TU Dresden @stefandiezlab.bsky.social · 19/07/2026
🔬 #JobAlert Interested in doing a PhD with us in #SyntheticBiology on the Reconstitution of Oscillatory Microtubule-Motor Systems? Check shorturl.at/wis5P (note the eligibility criteria) or/and get in touch with us shorturl.at/WmgOD. Deadline: 31 July 2026 #WeAreHiring #AcademicJobs #ScienceJobs
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Matt Lycas @lycasworks.bsky.social · 27/04/2026
www.protocols.io/view/cryo-ex... New protocol alert!! Cryo-expansion microscopy of C. elegans and Tardigrades using the high pressure freezer!
protocols.io
Cryo-Expansion Microscopy of C. elegans and Tardigrades
Cryo-Expansion Microscopy of C. elegans and Tardigrades. Expansion microscopy (ExM) improves imaging r. Read full protocol, steps, and materials on protocols.io
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Reposted by Paul & Virginie - Centriole Lab
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 13/07/2026
From background to foreground: secondary antibodies coupled to lipophilic ATTO dyes enable high-density membrane labeling in super-resolution and expansion microscopy www.biorxiv.org/content/10.64898/20…
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Reposted by Paul & Virginie - Centriole Lab
Jana Helsen @helsenjana.bsky.social · 16/07/2026
I am starting my lab at the University of Geneva next January! Incredibly excited to soon be joining the MOCEL department as an Asst. Professor. The lab will use evolutionary cell biology to study chromosomes, centromeres & speciation 🧬🔬🌱 Intrigued, want to join or collaborate? 🔗 helsenlab.org
helsenlab.org
Helsen lab | chromosome and centromere evolution
The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...
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Reposted by Paul & Virginie - Centriole Lab
Lüders Lab @luderslab.bsky.social · 08/07/2026
How are complex #protein #structures such as #centrioles built? Fortunate to have participated in this study headed by Bryan Tsou’s lab! Rather than self-assembly, #centriole #biogenesis is driven by an inheritable template! 👀 🧵 Thread below👇 Full story: 🔗 doi.org/10.1038/s41467-026-74821-3
nature.com
Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1 - Nature Communications
Centriole biogenesis is regarded as template-free, variation-free, and genetically determined. Here, the authors describe an adaptable process where inheritance and selection both opera...
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Reposted by Paul & Virginie - Centriole Lab
Turner Lab @lab-turner.bsky.social · 08/07/2026
New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos
biorxiv.org
Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation
X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...
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Reposted by Paul & Virginie - Centriole Lab
Martin Jonikas @mjonikas.bsky.social · 15/06/2026
Pyrenoid tubules are essential for supercharging CO₂ fixation, but they're hard to resolve by microscopy. So, we physically expanded cells to see where different proteins go (3 examples below). The central tubule region appears specialized for CO₂ delivery! www.biorxiv.org/content/10.6...
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Reposted by Paul & Virginie - Centriole Lab
Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
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Reposted by Paul & Virginie - Centriole Lab
Ben Engel @cellarchlab.com · 03/07/2026
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬
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Felipe Opazo @opazo.bsky.social · 02/07/2026
New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚
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EuroCilia2027 @eurocilia.bsky.social · 01/07/2026
Big news! 🎉 Huge congratulations to Dr. Virginie Hamel (@centriolelab.bsky.social) on being elected an @embo.org Member. We are so excited to host her as a speaker at #EMBOCilia2027 to discuss her group's incredible work uncovering the mechanisms of centriole and cilia assembly. 🔬✨ #cilia
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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 30/06/2026
Honored and delighted to be elected an EMBO Member. A huge thank you to our amazing team, this recognition wouldn't be possible without you. Perfect day to celebrate together during our lab outing! 🎉 - Virginie
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EMBO @embo.org · 30/06/2026
Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 www.embo.org/press-releases/seventy… #EMBOMembers2026
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Biology-UNIGE @biology-unige.bsky.social · 30/06/2026
🌟 Warmest congratulations to Virginie Hamel @centriolelab.bsky.social on being elected a Member of the @embo.org This prestigious lifelong distinction recognizes your outstanding excellence in the life sciences! #centriole #U-ExM @mocel.bsky.social @sciencesunige.bsky.social
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Genes & Development @genesdev.bsky.social · 24/06/2026
🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning By Liu et al. and Jeremy Reiter ➡️ ow.ly/SOeZ50ZaaJo UCSF Helen Diller Family Comprehensive Cancer Center Chan Zuckerberg Biohub Network Biohub
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Deborah Bourc’his @deborahbourchis.bsky.social · 27/06/2026
Coupes drastiques du budget de la recherche + durcissement des règles d’attribution des financements ANR «Allez à l’ERC!» qu’ils disent, mais l’ERC saturée prend des mesures pour limiter les candidatures #deadend#recherchefrançaise Une petition semble vaine mais il faut commencer quelque part 👉
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Biology-UNIGE @biology-unige.bsky.social · 24/06/2026
We warmly congratulate Robbie #Loewith on receiving an @erc.europa.eu Advanced Grant 2025 : a well-deserved recognition of his exceptional research and scientific impact 👏 @mocel.bsky.social @sciencesunige.bsky.social www.unige.ch/recherche/en...
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Wieczorek Lab @mike-wieczorek.bsky.social · 23/06/2026
New preprint! In collaboration with the Steinmetz Lab at PSI we report cryo-EM structures of microtubules at up to 1.9 Å (!) resolution & in different nucleotide state mimics, suggesting a mechanism for lattice-induced GTP hydrolysis and why it leads to catastrophe: tinyurl.com/7cjrf863
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Manuel Thery @manuelthery.bsky.social · 19/06/2026
Is there a size limit for cells ? How can cells replicate inside the architecture of their environment? Why do cells self-destroy ? This 15-minute movie vimeo.com/1173229237 shows our 2026 edition of the Living Architectures project at the @museeorsay.bsky.social
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Svetlana Dodonova @dodonova-sveta.bsky.social · 19/06/2026
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
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EuroCilia2027 @eurocilia.bsky.social · 19/06/2026
🥉 Third Prize Winner! 🥉 Congrats to PhD student @anthonyrabate.bsky.social (Université Lyon 1) for this stunning shot, "A tulip field in the drosophila testis"! 🌷 These are young elongating spermatids captured via expansion microscopy. 🔬✨ #FluorescenceFriday #Cilia2027
The magenta highlights the nuclei of the spermatids, while the vibrant green tracks the axoneme stained with acetylated tubulin. The orange pinpoints the pericentriolar material stained with asterless.
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Melanie Bonhivers @mbonhivers.bsky.social · 12/06/2026
The CNRS has opened a Junior Professor Chair (CPJ) call in Parasitology, and the Microbiologie Fondamentale et Pathogénicité (MFP, Bordeaux) laboratory is among the potential host institutions. More information: www.insb.cnrs.fr/fr/cnrsinfo/... #Parasitology #Protozoology #ResearchJobs #CNRS
insb.cnrs.fr
Junior Professor Chairs (CPJ) 2026 – CNRS Biology
CNRS Biology is recruiting researchers through its Junior Professor Chair (CPJ) program, subject to final approval by the French Ministry of Higher Ed
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Toni Gabaldón @tonigabaldon.bsky.social · 10/06/2026
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
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Lara Krüger @lara-kruger.bsky.social · 09/06/2026
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
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Biohub @biohub.org · 04/06/2026
Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ
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James Gahan @jgahan.bsky.social · 20/05/2026
We are looking for a new colleague to join us in Galway. The position is in Biochemistry and if research focus lines up we hope the successful person will join us in the Centre for Chromosome biology (chromosome.ie). Reach out if you are interested in applying! tinyurl.com/2jy4rj3r
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EuroCilia2027 @eurocilia.bsky.social · 04/06/2026
Big congratulations to our winners: Smilla-Maria Koy (1st), Chandrama Ghosh (2nd), and Anthony Rabaté (3rd)! Check out their breath-taking micrographs and the rest of the Top 15 entries in the stunning poster attached. The future of cilia research looks beautiful. 📸 #Cilia2027
micrographs depicting cilia in different forms
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