iiinova — where your digital self keeps evolving

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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

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joe dobbs @joedobbs.bsky.social · 25/09/2026

Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...

cell.com

Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries

Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/09/2026

A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽

nature.com

MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods

MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...

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Reposted by Andrea Dallapè

mareikejordan.bsky.social @mareikejordan.bsky.social · 04/09/2026

Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)

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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/08/2026

Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging www.biorxiv.org/content/10.64898/20…

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Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026

Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...

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Rhys Grinter @rhyswg.bsky.social · 18/08/2026

Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5

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Florent Waltz @florentwaltz.bsky.social · 27/07/2026

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

nature.com

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

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Nicholas Bellono @nbellono.bsky.social · 09/07/2026

How did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...

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Chi-Min Ho @cmholab.bsky.social · 30/06/2026

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

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Nogales Lab @nogaleslab.bsky.social · 29/06/2026

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

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Reposted by Andrea Dallapè

Plaschka lab @plaschkalab.bsky.social · 18/06/2026

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

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Reposted by Andrea Dallapè

Biohub @biohub.org · 16/06/2026

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

Diagram of FIB-SEM with integrated fluorescence microscope alongside cryo lamella micrograph and 3D segmentation highlighting targeted centrioles

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Reposted by Andrea Dallapè

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 06/06/2026

A Crossed Laser Phase Plate for CryoEM www.biorxiv.org/content/10.64898/20…

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Reposted by Andrea Dallapè

arXiv q-bio.QM Quantitative Methods @qbioqm-bot.bsky.social · 01/06/2026

Muyuan Chen: Gaussian Mixture Model-Based Focused Refinement for Enhanced Flexible Structure Determination in CryoEM and CryoET arxiv.org/abs/2605.30518 arxiv.org/pdf/2605.30518 arxiv.org/html/2605.30518

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cryoEM papers @cryoempapers.bsky.social · 29/05/2026

The molecular architecture of tunneling nanotubes www.biorxiv.org/content/10.64898/2026.05.27.728322v1 #cryoEM

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Reposted by Andrea Dallapè

Cell Press @cellpress.bsky.social · 29/05/2026

"Mitochondria-lysosome coupling contributes to lysosome acidification and aging" Read more in Molecular Cell: www.cell.com/molecular-ce... Chuankai Zhou & colleagues @cp-molcell.bsky.social

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Reposted by Andrea Dallapè

cryoEM papers @cryoempapers.bsky.social · 22/05/2026

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging www.biorxiv.org/content/10.64898/2026.05.19.726344v1 #cryoEM

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Reposted by Andrea Dallapè

Maria Barna @mbarnalab.bsky.social · 21/05/2026

’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

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Reposted by Andrea Dallapè

Higor Rosa @hvdrosa.bsky.social · 14/05/2026

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

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Bram Verhagen @bramverhagen.bsky.social · 13/05/2026

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

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cryoEM papers @cryoempapers.bsky.social · 24/04/2026

Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology www.biorxiv.org/content/10.64898/2026.04.21.719848v1 #cryoEM

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Reposted by Andrea Dallapè

Sylvie Callegari @sylviecallegari.bsky.social · 06/04/2026

Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535

seek.com.au

Biochemist/Cell Biologist Research Officer Job in Parkville, Melbourne VIC - SEEK

An excellent opportunity is available for a Research Officer / Senior Research Officer to join the Callegari Lab at WEHI.

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Bui Lab @McGill @builab.bsky.social · 12/04/2026

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

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Debnath Ghosal @debnathghosal.bsky.social · 12/04/2026

One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶‍♂️

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Reposted by Andrea Dallapè

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 07/04/2026

Molecular architecture of the ciliary base in mammalian multiciliated cells www.biorxiv.org/content/10.64898/20…

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Jan-Hannes Schaefer @jhschaef.bsky.social · 07/04/2026

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Blender Rendering of vitrified HA trimer with DM at the air-water interface

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Reposted by Andrea Dallapè

Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

youtube.com

Cryo-EM structure of yeast telomerase

YouTube video by MRC Laboratory of Molecular Biology

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Reposted by Andrea Dallapè

Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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Sjors Scheres @sjorsscheres.bsky.social · 18/03/2026

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

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cryoEM papers @cryoempapers.bsky.social · 19/02/2026

The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior pubmed.ncbi.nlm.nih.gov/41706843/ #cryoEM

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · 17/02/2026

Pulsed #lasers integrated with #cryoEM: @fitzpatricklab.bsky.social postdoc Daniel Du aims to boost contrast in #cryoET zuckermaninstitute.columbia.edu/making-world-s-best-microscopes-biology-better zuckermaninstitute.columbia.edu/science-life-daniel-du elifesciences.org/reviewed-preprints/109793v1

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cryoEM papers @cryoempapers.bsky.social · 19/02/2026

Integrase anchors viral RNA to the HIV-1 capsid interior pubmed.ncbi.nlm.nih.gov/41708858/ #cryoEM

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Kranzusch Lab @kranzuschlab.bsky.social · 17/02/2026

Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps: www.cell.com/cell/fulltex...

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 17/02/2026

Beautiful #phage structure 🤩 Congrats to the colleagues in Brazil! 🍊🦠 www.biorxiv.org/content/10.6... #CryoEM #xanthomonas

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Dimitry Tegunov @dtegunov.bsky.social · 16/02/2026

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

warpem.github.io

Euler Hunt

Can you find the Euler angles of a cryo-EM projection?

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Edoardo Gianni @edogia.bsky.social · 13/02/2026

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

science.org

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

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Lucas Tafur @tafurlab.bsky.social · 13/02/2026

It took a while but it’s finally published! The GAP activity of SEAC (GATOR) is a metabolic switch that allows cells to quickly respond to changes in amino acid levels, both for inhibition and reactivation.

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Clockwork @watchclockwork.com · 31/01/2026

💪 NEW VIDEO: Flying over the A-band of an atomic-scale model of a vertebrate muscle sarcomere. Let's explore the molecular mechanics that make your muscles work. Rendered using @bradyajohnston.bsky.social 's molecular nodes Model based on the incredible work of the @raunser-lab.bsky.social lab

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Ben Engel @cellarchlab.com · 30/01/2026

Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro 🧪 and in vivo 🦠 Thanks for the very fun collaboration! 🤗 #PlantScience 🌾 #TeamTomo 🔬 #LivingPhysics 🧬🧶

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Structura Biotechnology @structurabio.bsky.social · 27/01/2026

🚀 CryoSPARC v5.0 BETA is here! We’re excited to deploy another major #CryoSPARC release to help enable and accelerate #cryoEM data analysis. v5 has a redesigned underlying software system and many new features - highlights in thread! Full changelog: cryosparc.com/updates/v5.0.0

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Mari de Sautu @maridesautu.bsky.social · 27/01/2026

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...

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arXiv q-bio.QM Quantitative Methods @qbioqm-bot.bsky.social · 27/01/2026

Muyuan Chen, Muchen Li, Renjie Liao: Point transformer for protein structural heterogeneity analysis using CryoEM arxiv.org/abs/2601.18713 arxiv.org/pdf/2601.18713 arxiv.org/html/2601.18713

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