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Ricardo D. Righetto

@lifeonthewedge.bsky.social
707 followers 976 following 282 posts

Staff scientist @biozentrum.unibas.ch using algorithms to look at tiny stuff inside cells, or #cryoET if you prefer. Here I talk mostly about my research. Views my own. 🇧🇷 in 🇨🇭

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Reposted by Ricardo D. Righetto
Julie S. Lalonde @julieslalonde.bsky.social · 25/09/2026
- À la carte living conditions where everything is hyper personalized and you get what YOU want delivered to YOU when YOU want it. And therefore, you don't have to think beyond yourself, so you assume everything is either for you *specifically* or it's wrong.
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Manon Demulder @manondemulder.bsky.social · 02/10/2026
If you’ve always been curious about how algae fix carbon, @phaips.vd.st, @cellarchlab.com and I have put together the quickest route into pyrenoids. And if you don’t feel like reading at all, we have an accompanying poster doi.org/10.1242/jcs....
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Archaea Biology Vienna @archaea-vienna.bsky.social · 01/10/2026
Our paper on the dynamics of Asgard archaea (Promethearchaeota) is now out in Nature! Huge thanks to the reviewers for helping make the manuscript stronger. www.nature.com/articles/s41... Two “Lokis” stained for Lokiactin (FastAct, magenta), reaching toward each other to celebrate 🎉 #archaea
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Oli Clarke @olibclarke.bsky.social · 30/09/2026
Added a couple of things to coot1-trimmings: * Option to set default model/map appearance to mimic Coot 0.9.x * Metal helper to semi-automatically make links for the current ion * Slider to interactively set map brightness (demos of brightness slider & metal helper in subsequent posts)
github.com
GitHub - olibclarke/coot1-trimmings: Customized keybindings and scripts for Coot 1.x
Customized keybindings and scripts for Coot 1.x. Contribute to olibclarke/coot1-trimmings development by creating an account on GitHub.
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Paul Klee @paul-klee.bsky.social · 29/09/2026
Separation in the Evening www.wikiart.org/en/paul-klee/separa…
Separation in the Evening
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Marc Robinson-Rechavi @marcrr.bsky.social · 28/09/2026
I'm not writing in the NYT and I won't word it carefully: it's clear that AI companies are stealing researchers' work (and why wouldn't they? they steal artists' and journalists' work with no consequences), and I warned my group about it this morning.
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Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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joe dobbs @joedobbs.bsky.social · 25/09/2026
Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...
cell.com
Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries
Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...
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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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ChimeraX @chimerax.ucsf.edu · 25/09/2026
Make natural language requests to ChimeraX with the new Pellaeon plugin developed by Yam Amir that works with many free and paid large language models. Get Pellaeon using ChimeraX menu Tools / More Tools.... cxtoolshed.rbvi.ucsf.edu/apps/chimera...
PAR1 molecular structure shown in ChimeraX using Pellaeon chat bot.
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Ben Engel @cellarchlab.com · 24/09/2026
Insane in the #MemBrain 🤖🧠 #TeamTomo 🧪
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Gregg Gonsalves @gregggonsalves.bsky.social · 20/09/2026
This is very sad news. Paulo was one of the greats. Brazil was a leader in ensuring that people living with HIV got access to antiretroviral therapy even when "experts" said it couldn't be done outside of rich countries in the global North. www.cartacapital.com.br/saude/morre-...
cartacapital.com.br
Médico atuou na criação de políticas de prevenção e tratamento
Médico atuou na criação de políticas de prevenção e tratamento
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Higor Rosa @hvdrosa.bsky.social · 17/09/2026
IMOD models, eLab/paper notes, "that feature in that one tomo"... keeping track across 1000s of #CryoET tomograms was hard! TOMATO puts tomos and notes in one place. Combine it with LLMs and it's an awesome base for building more: morphometrics, contactomes, anything turning visuals into numbers! 🥳😍
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 14/09/2026
Visited this weekend 'Val Mucilaginosa', a stunning VR experience created by Isabell Bullerschen inspired by our #cryoET segmentations of cyanobacteria 🦠👽🖖🏽 On view at the Botanical Garden in Zurich until October 11th 🤩 www.bg.uzh.ch/en/research/...
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Siobhán @shibbi.me · 12/09/2026
Damn good point.
Terrence Tao: Until recently, this polite fiction has worked, because human mathematicians knew, possibly subconsciously, to use both childlike and adult skills when solving these problems, even if they might only publicly admit to the latter. But modern Al tools, when directed without such expert supervision, can now be aimed all too easily at the ostensible goals of the field, without any incentive to take the slow, whimsical path. The flag is captured, the goal scored, and the problem is solved; but at the cost of lessons learned, insights gained, collaborations formed, and new targets located.

@fleetingbytes: the terrance tao crashout is something to behold

@no_earthquake: imo a lot of people are deeply misreading this as lamenting the death of personal pleasures in the face of efficient goal-attaining when it's a lament of the death of actual goal-attaining in the face of optimized things-shaped-like-goals-attaining
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Kranzusch Lab @kranzuschlab.bsky.social · 10/09/2026
Stunning cryo-ET analysis from the Harrison Lab capturing every stage of how non-membrane viruses infect animal cells www.science.org/doi/10.1126/...
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Virginie Uhlmann @virginieuhlmann.bsky.social · 11/09/2026
Research software is costly and time-consuming to produce because it requires focused time from developers who have invested years learning to master their craft, just like art. There is nothing to celebrate about relinquishing intellectual expertise and mastery in favor of fast and cheap.
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 11/09/2026
Very proud of the team, led by @baukjeje.bsky.social & @fmikus.bsky.social To all of you doing #Expansion #Microscopy #UExM Try Concanavalin A. Its cheap, easy to use & labels the #nuclear #Envelope @moorefound.bsky.social @embl.org @sciencesunige.bsky.social @erc.europa.eu @snsf.ch
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 10/09/2026
Amazing opportunity here 😉👇🏽
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Vincent van Gogh @vangogh.bsky.social · 10/09/2026
The Olive Trees (June–July 1889) came from the groves beyond the asylum walls of Saint-Rémy, painted on supervised walks. He called it the daylight partner to The Starry Night: same summer, same accentuated outlines, but with sunlight rather than starlight.
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The Man in Seat 61 @seatsixtyone.bsky.social · 09/09/2026
BREAKING: Today, Eurail (established 1959) & Interrail (established 1972) merge into a single European railpass range for EVERYONE regardless of nationality or country of residence, called INTERRAIL. Read why I think this is excellent news here: www.seat61.com/news.htm
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Ben Engel @cellarchlab.com · 08/09/2026
MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪
BioRxiv FTW
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 08/09/2026
The beauty of posting in @biorxivpreprint.bsky.social. This amazing tool was available for the community long before it showed up on a journal. I even forgot this publication was not "peer-reviewed", but it was definitively "community-reviewed". Kudos to @lorenzlamm.bsky.social and all the authors!
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/09/2026
A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽
nature.com
MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods
MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...
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Mark Rothko @markrothko.bsky.social · 07/09/2026
Black, Red and Black botfrens.com/collections/25/content…
Black, Red and Black
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 02/09/2026
aka biology 👇🏽
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Petra Korlević @petrathepostdoc.bsky.social · 30/08/2026
updated and improved for MORE 🇧🇷 lil guys gals and things on fire! #folklore #mythology
big collage of 28 brazilian cryptids, from top left:
- CURUPIRA 
- BOITATA 
- MULA SEM CABECA
- CURACANGA
- JARAGUA
- BOTO-COR-DE-ROSA
- CUCA
- IARA
- MATINTA-PERERA
- CAIPORA and PORCO-DO-MATO
- CABOCLO-D'AGUA
- SACI-PERERE
- PE DE GARRAFA
- GARANTIDO and CAPRICHOSO
- MAPINGUARI
- CABECA DE CUIA
- PERNA CABELUDA
- COMADRE FULOZINHA
- ALAMOA
- NEGRINHO DO PASTOREIO
- PISADEIRA
- CORPO-SECO
- BOI BUMBA
- PAPA-FIGO
- TUTU MARAMBA
- CABECA SEM MULA
- CHUPA-CU
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/08/2026
Run AlphaFold2 locally in your browser via WebGPU, no installation needed, it's just a static webpage using your own GPU or CPU. Short proteins run in seconds. Larger ones are still slow: a 291-aa protein takes ~7 minutes on my M4 Pro. ❗It's just a PoC. 🌐 martin-steinegger.github.io/alphafold2-w...
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Janani Durairaj (Jay) @ninjani.bsky.social · 28/08/2026
Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!
compare, predict, design
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Carapanã @carapanarana.bsky.social · 29/08/2026
Percebam que todos jornalistas que fizeram as apurações dos crimes dos Bolsonaro foram demitidos dos grandes veículos. Juliana Dal Piva apurou os imóveis, André Borges apurou o roubo das jóias, Jamil Chade apurou as insanidades do 4chanceler, a Daniela Lima foi feroz na cobertura do 8/1 etc.
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Carapanã @carapanarana.bsky.social · 29/08/2026
Todo esse colunismo ilustrado sofre de uma espécie de estupidez crônica de que existe um "meio termo" entre uma esquerda moderada que nasceu na democracia e um bando de malucos prometendo guerra civil e banhos de sangue como soluções mágicas. É um grupo elitizado, covarde e fraco.
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Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 27/08/2026
Very happy to see our Nature Reviews Molecular Cell Biology Roadmap out! A fantastic collective effort, led by Carsten Janke and Zdenek Lansky, together with an amazing group of colleagues, and sparked by inspiring discussions at the Fondation des Treilles. www.nature.com/articles/s41...
nature.com
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease - Nature Reviews Molecular Cell Biology
Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 26/08/2026
Foldseek-Interface enables fast search/clustering of the protein interface universe! We clustered 3.1M PDB dimers into 77,167 groups and found new interfaces keep appearing even as fold discovery plateaus. 🧵 📄 www.biorxiv.org/content/10.6... 🔎 search.foldseek.com/interface 🌐 interface.foldseek.com
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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chanceler rapositos @raposatriste.bsky.social · 25/08/2026
a dolly parton é tipo o milkshake duck ao contrário cada vez que descubro algo novo sobre ela é sempre algo lindo e maravilhoso
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Emmaeli @emmaelie.bsky.social · 24/12/2023
Symbol of Hope Sliman Mansour
Sliman Mansour  
Symbol of Hope, 1985
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Joan Miró @joanmiro.bsky.social · 23/08/2026
The Nightingale's Song at Midnight and the Morning Rain www.wikiart.org/en/joan-miro/the-ni…
The Nightingale's Song at Midnight and the Morning Rain
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Deadly Fungal Storm @yukisenoue.bsky.social · 22/08/2026
web.archive.org/web/20220902... PROTEJAM O INTERNET ARCHIVE
web.archive.org
Bolsopedia: A enciclopédia do Bolsonarismo
Tudo que Bolsonaro fez em 4 anos de governo (e não quer que você saiba)
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Erin Biba @erinbiba.bsky.social · 21/08/2026
There are many uses for AI in science - modeling, data analysis, certain diagnostics - none of those are LLMs and frankly not even really “AI” as we’ve come to know it at all and TBH we need a different name for this kind of “AI” so the science stuff can stop getting dragged into this argument.
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Cool Bike Art @coolbikeart1.bsky.social · 18/08/2026
Hey, let's not forget that a traffic safety competition was the premise behind this classic
Calvin and Hobbes by Bill Watterson in which Calvin's dad rages against drivers for Calvin's traffic safety poster.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 16/08/2026
2/2 ...all scientists – not just human geneticists – should oppose this with all their might, for the sake of their own humanity. here at STC, we reject any lunatic idea of 'white supremacy' and consider eugenics the lousy science that it always was.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 16/08/2026
the rise of eugenics, fueled by the ideology of white supremacy, had horrific consequences in the 20th century. It is hardly likely that things will turn out any differently in the 21st century. ...1/2
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Kashish Singh @kashishsingh.bsky.social · 13/08/2026
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
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Dagmar Iber & CoBi @iberd.bsky.social · 13/08/2026
🎉 Our paper is out in Cell Systems @cp-cellsystems.bsky.social ! How does an embryo build an energy-efficient fractal lung before the first breath? 📄 doi.org/10.1016/j.ce... 🧵 bsky.app/profile/iberd.bsky.social/post/3lfrdth6k4c22 @maltemederacke.bsky.social @kevinyamauchi.bsky.social
doi.org
Redirecting
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Plant Science Spotlight @plant-sci.bsky.social · 11/08/2026
🧬🌱 Algal chloroplast ribosomes have a unique arm domain, revealed by cryo-ET and cryo-EM. It may stabilize mRNA and organize polysomes. Chloroplast translation is more structurally diverse than expected. #plantscience @natplants.nature.com www.nature.com/articles/s41...
nature.com
Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants
Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...
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bia @pniew.ski · 11/08/2026
pensando em como a usp, a maior instituição de ensino superior do brasil, tinha armazenamento ilimitado no google drive e milhares de alunos, professores e pesquisadores depositavam tudo ali. até que um dia o google resolveu limitar pra 20 gb por pessoa. e ficou por isso mesmo
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Total Internal Reflection🇬🇧🇺🇸🇺🇦 @tirscienceblog.bsky.social · 07/08/2026
🚨🚨🚨 #Editor Job alert! I’m not an editor, but if I decided to pursue career in scientific #publishing, then Company of Biologists is the organisation I’d most want to work for, & @jcellsci.bsky.social is the journal I’d want to work at 🤩 Details + link to job description in the link 👇
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Jamie Blaza @jnb-lab.bsky.social · 10/08/2026
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
jobs.york.ac.uk
Jobs - The University of York
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Alex Wellerstein @wellerstein.bsky.social · 09/08/2026
81 years ago today, on August 9, 1945, an atomic bomb was dropped upon the city of Nagasaki, Japan, by the United States. This was 3 days after the first atomic attack on Hiroshima.
Nagasaki, bomber's eye view: Close-up view of the head of the mushroom cloud at the Nagasaki explosion, as seen from either the bomber or the observation plane.Nagasaki, distant ground view: Photo of the Nagasaki cloud taken ~15 minutes after the atomic bomb detonation, by Hiromichi Matsuda, stationed at Koyagi-jima Island, some 5 miles / 8 km away.Nagasaki, before and after, aerial views. Nagasaki, ground view, some weeks after the attack.
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Kristian G. Andersen @kgandersen.bsky.social · 08/08/2026
"Accusing him of crimes and deception wasn’t enough; the release of the diary was meant to inflict public humiliation on him". Very good article and spot on. www.theatlantic.com/ideas/2026/0...
theatlantic.com
Why MAGA Is So Obsessed With Fauci
In the aftermath of pandemics, people either try to forget them or find others to blame for them.
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