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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 10/06/2026

Dr Sylvie Callegari, recent winner of the Burnet Prize, shares her thoughts on artificial intelligence in research, who inspires her most and what she would do if she could redesign mitochondria from scratch. Read more: www.wehi.edu.au/news/a-futur...

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Sylvie Callegari @sylviecallegari.bsky.social · 23/04/2026

Glycogen is ubiquitinated in vivo! And there is a clever method to detect it. It had been a privilege seeing this story come together by my colleagues in the @komanderlab.bsky.social. This will no doubt have important implications for metabolism.

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Sylvie Callegari @sylviecallegari.bsky.social · 06/04/2026

Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535

seek.com.au

Biochemist/Cell Biologist Research Officer Job in Parkville, Melbourne VIC - SEEK

An excellent opportunity is available for a Research Officer / Senior Research Officer to join the Callegari Lab at WEHI.

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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 22/03/2026

WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field. Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social www.wehi.edu.au/news/new-enz...

Researchers standing in front of whiteboard with scientific information

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Reposted by Sylvie Callegari

Rob Klose @robklose.bsky.social · 13/03/2026

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

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Reposted by Sylvie Callegari

jake @mediocre-jake.bsky.social · 13/03/2026

Lipids Meet Immunity: Metabolic Control of cGAS-STING Having worked in lipid metabolism and cGAS-STING, I have an appreciation for the regulation of cGAS-STING by lipids, which I co-wrote. www.mdpi.com/2813-7086/3/... @wehi-research.bsky.social @sahmri.bsky.social

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Reposted by Sylvie Callegari

Tom McLean @tommclean.bsky.social · 25/02/2026

Come do a PhD with me and @trevor-lithgow.bsky.social at @monashuniversity.bsky.social ! We’re at the leading edge of pathogen biology using cutting edge Cryo-EM and AI-driven genetic screens to uncover the mysteries of outer membrane biology. Reach out to me for a chat! macsys.org/phd-scholars...

macsys.org

PhD Scholarship at Monash University - MACSYS

Do cutting-edge research at the intersection of cryo‑EM, genome-wide profiling, and AI-driven modelling. Work with world‑class cryo-EM/cryo-ET imaging and AI tools to discover how the dangerous bacter...

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Sylvie Callegari @sylviecallegari.bsky.social · 11/02/2026

I'm hiring! If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply! WEHI is a great place to work with access to state-of-the art cryo-EM facilities. Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...

wehi.wd3.myworkdayjobs.com

Research Officer

Job Title Research Officer Job Description An excellent opportunity is available for a Research Officer/Senior Research Officer to join the Callegari Lab in the Ubiquitin Signalling Division at Austra...

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Sylvie Callegari @sylviecallegari.bsky.social · 04/02/2026

After a long (but fun!) postdoc journey, I am very excited to share that I will start my own lab in the Ubiquitin Signalling Division at WEHI. We will study how ubiquitin controls mitochondrial health and its role in neurodegenerative disease. Hiring soon!

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Reposted by Sylvie Callegari

Australian Museum Eureka Prizes @eurekaprizes.bsky.social · 29/01/2026

🧠 Dr Callegari shares the role collaboration has made in the WEHI group's research, as their insights deepen understanding of genetic mutations of Parkinson's disease & new avenues for drug discovery. 👉 Read more: bit.ly/4sKbh9s @wehi-research.bsky.social

Team of four researchers standing outside WEHI building, smiling at the camera.

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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 15/01/2026

💡Solving decades-long mysteries with cryoEM. 💥Brilliant science + best tech = life-saving medical research. Shaping the future of health through bold new approaches. #ParkinsonsDisease

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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 05/01/2026

Big cheers to our 12 researchers awarded $14M in NHMRC Ideas Grants! Funding will drive pioneering research into #Parkinson’s, #coeliac disease, #cancer and more, shaping the future of health. 🧵1/2

L-R 1st row:Dr Cindy Audiger, Dr Kira Behrens, Dr Sylvie Callegari, Dr Wing Fuk (Luke) Chan
L-R 2nd row: Dr Melinda Hardy, Dr Miles Horton, Professor David Huang, Dr Andre Samson
L-R 3rd row: Professor Kate Sutherland, Dr Tom Weber, Dr Clare Weeden and Professor Ian Wicks

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Reposted by Sylvie Callegari

Komander Lab @komanderlab.bsky.social · 23/12/2025

A big year for the lab! We hosted Australia’s first ubiquitin summit in Lorne, Published the structure of PINK1 on a mitochondrial translocase array, Reported a new PLpro inhibitor for long COVID, Celebrated 3 PhD and 1 honours completions, Went on a lab footy trip, 🏈 Won the Eureka prize!! 🏆

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Sylvie Callegari @sylviecallegari.bsky.social · 20/10/2025

We’re hiring a research assistant! If you have experience in protein production and purification (bacterial and/or insect systems) and are interested in early-stage drug discovery, please apply! 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex....

wehi.wd3.myworkdayjobs.com

Research Assistant

Job Title Research Assistant Job Description An exciting opportunity exists for an experienced Research Assistant to work with Dr. Sylvie Callegari and Prof. David Komander within the Ubiquitin Signal...

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Reposted by Sylvie Callegari

Michele Frison @frisophagy.bsky.social · 10/10/2025

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility. www.science.org/doi/10.1126/...

science.org

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

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Sylvie Callegari @sylviecallegari.bsky.social · 03/10/2025

Really enjoyed the #ASBMB2025 conference in Brisbane this week. It's an honour to get to present to this audience and winning an oral presentation prize was an unexpected bonus!

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Reposted by Sylvie Callegari

Josh Hardy @joshuamhardy.bsky.social · 28/09/2025

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

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Reposted by Sylvie Callegari

WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 03/09/2025

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

📸 L–R: Professor David Komander, Dr Nicholas Kirk, Dr Sylvie Callegari and Dr Alisa Glukhova.

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Reposted by Sylvie Callegari

Marnie Blewitt @marnieblewitt.bsky.social · 03/09/2025

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

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Reposted by Sylvie Callegari

Brett Collins @brettcollins.bsky.social · 02/09/2025

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

uq.wd3.myworkdayjobs.com

Director, Centre for Chemistry and Drug Discovery

Institute for Molecular Bioscience Join a university ranked in the world’s top 50 Australia’s #1 research institute Based at St Lucia Campus About UQ What started as Queensland's first university in 1...

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Reposted by Sylvie Callegari

Dan Grabarczyk @dangrabarczyk.bsky.social · 28/08/2025

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

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Reposted by Sylvie Callegari

iubmb.bsky.social @iubmb.bsky.social · 08/08/2025

Our June Newsletter highlights IUBMB activities including a note from the President and updates on the IUBMB Trainee Initiative ➡️http://bit.ly/45ai6r1

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Reposted by Sylvie Callegari

Australian Museum Eureka Prizes @eurekaprizes.bsky.social · 31/07/2025

PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research. Learn more: youtu.be/senXARXzO20 #EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social

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Sylvie Callegari @sylviecallegari.bsky.social · 31/07/2025

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.social

youtube.com

PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research

YouTube video by Australian Museum

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Reposted by Sylvie Callegari

Derek Lowe @dereklowe.bsky.social · 30/07/2025

“Why do we sleep” has been a surprisingly hard question. But it looks like the answer may be “ Because we breathe”. Our mitochondria need a break!

science.org

It All Comes Down to the Mitochondria

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Reposted by Sylvie Callegari

Komander Lab @komanderlab.bsky.social · 11/07/2025

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org #ubiquitin

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Reposted by Sylvie Callegari

Rashmi Agrata @rashmiagrata.bsky.social · 04/07/2025

Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

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Reposted by Sylvie Callegari

Science Magazine @science.org · 23/05/2025

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

scim.ag

Silencing mitochondrial gene expression in living cells

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

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Reposted by Sylvie Callegari

Micha Rapé Lab @micharapelab.bsky.social · 07/05/2025

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

nature.com

Molecular basis of SIFI activity in the integrated stress response - Nature

Nature - Molecular basis of SIFI activity in the integrated stress response

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Sylvie Callegari @sylviecallegari.bsky.social · 18/04/2025

Stunning photo of Mars on the cover of Science this week! And super proud that our structure of PINK1 stalled at mitochondrial translocases also gets a cover mention 😊. It's now out in print on page 303!

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Reposted by Sylvie Callegari

Komander Lab @komanderlab.bsky.social · 07/04/2025

Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org See you there!

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Reposted by Sylvie Callegari

Cooty McCootFace @cootymccootface.bsky.social · 15/03/2025

Human PINK1 at a TOM-VDADC array Structure of the Week/Month/Year(?)! 9eih. Sylvia Callegari...David Komander, Science 13 March 2025. #coot Fancy mode Copyright/license-free - i.e. freely reproducible. Coot 1.1.14 coming soon!

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Reposted by Sylvie Callegari

Jim Hurley @jimhurley.bsky.social · 25/03/2025

PINK1/Parkin-dependent mitophagy caught in situ by cryo-ET! New preprint www.biorxiv.org/content/10.1... led by @kev-in-situ-et.bsky.social. This has been a long-standing goal of team @mito911.bsky.social within the @asapresearch.parkinsonsroadmap.org initiative.

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Reposted by Sylvie Callegari

Florent Waltz @florentwaltz.bsky.social · 21/03/2025

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

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Reposted by Sylvie Callegari

Ben Engel @cellarchlab.com · 20/03/2025

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

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Sylvie Callegari @sylviecallegari.bsky.social · 13/03/2025

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

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Reposted by Sylvie Callegari

Trevor Lithgow @trevor-lithgow.bsky.social · 12/02/2025

Amazing talk by @sylviecallegari.bsky.social so great to see the TOM complex back at Lorne, and capturing substrate in the channel of Tom40 … fabulous

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Reposted by Sylvie Callegari

Micha Rapé Lab @micharapelab.bsky.social · 16/01/2025

Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates! www.sciencedirect.com/science/arti...

sciencedirect.com

Reacting to reductive stress at the mitochondrial import gate

A byproduct of mitochondrial energy production is the generation of reactive oxygen species (ROS). Too much ROS is toxic, but ROS deficiency is equall…

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Reposted by Sylvie Callegari

Rashmi Agrata @rashmiagrata.bsky.social · 17/01/2025

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social

'Ubiquitin Lysine-Linkages' from the review 'Ubiquitin: a structural perspective' in Molecular Cell

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Sylvie Callegari @sylviecallegari.bsky.social · 14/01/2025

A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this! Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Original article: www.cell.com/molecular-ce...

kwnsfk27.r.eu-west-1.awstrack.me

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