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Scientists may have identified one of the mysterious molecules that pack into the cores of tau fibrils. A chemical that modifies polyubiquitin changed core structures, suggesting polyubiquitin is part...

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.

Columbia scientists caught a malaria parasite in the act of breaking into a blood cell, revealing a parasite machine that reshapes the cell from the inside. They then designed a&nb...

Galvanin is an electric-field sensor that links electrical cues to directed migration in rapidly moving cells.

Atomistic structural ensembles of protein folding intermediates on the ribosome are resolved by comprehensive 19F nuclear magnetic resonance analyses integrated with molecular dynamics simulations, pr...

Phase contrast enables structures of smaller proteins, could drive in-cell proteomics

This study elucidates the structural mechanism of HEP-50768, a novel MRGPRX4 inverse agonist, and demonstrates its potent anti-itch efficacy and favorable safety in preclinical models, positioning it ...

Taking images of tiny structures within cells is tricky business. One technique, cryogenic electron tomography (cryoET), shoots electrons through a frozen sample.

YouTube video by Kihara Bioinformatics Lab

The basic features of dopamine release sites are still largely unknown. Here, the authors determine the ultrastructure of fluorescent dopaminergic and glutamatergic synaptosomes in mouse striatum usin...

As 2025 comes to an end, we want to highlight some of the rising young faculty members who have published their exciting work from different areas of structural biology in Structure this year. We have...