iiinova — where your digital self keeps evolving

Dimitry Tegunov @dtegunov.bsky.social · 17/09/2026

There are countless houseboats in Sausalito, but this is the first time I see one on the move

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Dimitry Tegunov @dtegunov.bsky.social · 25/08/2026

This Relay thing sure is getting popular in Europe now

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Reposted by Dimitry Tegunov

Przemek Dutka @przemekdut.bsky.social · 11/08/2026

Interested in cutting-edge industrial cryo-EM/ET? Join us!

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Reposted by Dimitry Tegunov

Matt Johnson @drmatthewcjohnson.bsky.social · 11/08/2026

Interested in a career in industry cryoEM? We're hiring! We seek a cryoEM/cryoET expert to join our team at Genentech advance our mission to provide high-resolution structural insights into biological macromolecules involved in health and disease. Apply at: careers.gene.com/us/en/job/20...

careers.gene.com

Systems Specialist II in South San Francisco, California, United States of America | Manufacturing & Engineering at Genentech

Apply for Systems Specialist II job with Genentech in South San Francisco, California, United States of America. Manufacturing & Engineering at Genentech

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Dimitry Tegunov @dtegunov.bsky.social · 07/08/2026

Personally, I file those under in cheatu. Which isn't a bad thing: whenever you can get enough native context without having to FIB or even do tomography, you should do it.

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Dimitry Tegunov @dtegunov.bsky.social · 13/06/2026

So many people waking up today wishing they had prompted Fable a bit longer last night 😱 The government's reaction is completely overblown, of course. But it is a bit better than Opus 4.8 on average – enough that I wouldn't go back voluntarily if cost wasn't a factor

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Reposted by Dimitry Tegunov

cryoEM papers @cryoempapers.bsky.social · 27/05/2026

CryoARC: Atomic-resolution conformational landscapes of protein assemblies from cryo-EM single particles with evolutionary priors www.biorxiv.org/content/10.64898/2026.05.25.727696v1 #cryoEM

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Reposted by Dimitry Tegunov

Marten Chaillet @martenchaillet.bsky.social · 03/05/2026

MissAlignment is out!!! Our new software that improves reference-free tilt series alignment by mimicking human intuition. Check out Dimitry's beautiful thread for a quick summary! And the preprint for more details: www.biorxiv.org/content/10.6... The program: github.com/warpem/miss-...

biorxiv.org

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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

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Dimitry Tegunov @dtegunov.bsky.social · 30/04/2026

Now my mailing list reply bot is getting spam targeted specifically at agents: containing an API key for the advertised service, and instructions to try it out and to copy part of the message as a skill .md to Claude's config. I wonder how often Claws running without any human oversight bite on that

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Dimitry Tegunov @dtegunov.bsky.social · 09/04/2026

Looks like electron cryo-microscopy/tomography has finally lost the battle

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Dimitry Tegunov @dtegunov.bsky.social · 16/02/2026

Somewhat related: I was looking for a JS library to read MRC files a while ago, but couldn't find one (sorry if I missed it). So you can now “npm install @warpem/mrc-parser” github.com/warpem/mrc-p...

github.com

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Dimitry Tegunov @dtegunov.bsky.social · 16/02/2026

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

warpem.github.io

Euler Hunt

Can you find the Euler angles of a cryo-EM projection?

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Dimitry Tegunov @dtegunov.bsky.social · 13/02/2026

A cats lock key that lets you quickly disable the keyboard when a cat approaches it would be a lot more useful than the antiquated caps lock

Caps lock button on an Apple keyboard, activated by a cat stepping on it

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Dimitry Tegunov @dtegunov.bsky.social · 12/02/2026

What is the current resolution record for in situ nucleosomes? The best unofficial result I remember seeing was around 7 Å, but I feel like I've heard a better figure mentioned somewhere already

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Dimitry Tegunov @dtegunov.bsky.social · 06/02/2026

California is famous for its sunsets, but sunny early mornings are the real magic here

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Dimitry Tegunov @dtegunov.bsky.social · 01/02/2026

Do we have “I am a robot” CAPTCHAs for Moltbook yet?

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Dimitry Tegunov @dtegunov.bsky.social · 26/01/2026

Super happy to finally see native vertical tabs in Chrome, but why why why is the + button all the way at the bottom? #uxsky

When using vertical tabs in Chrome, the tabs and the new tab button are light-years apart

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Dimitry Tegunov @dtegunov.bsky.social · 23/01/2026

If someone's age is a prime number, are they in their prime?

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Dimitry Tegunov @dtegunov.bsky.social · 22/01/2026

This exciting new method has a bright future!

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Dimitry Tegunov @dtegunov.bsky.social · 14/01/2026

Great CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that.

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Dimitry Tegunov @dtegunov.bsky.social · 01/01/2026

2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆

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Dimitry Tegunov @dtegunov.bsky.social · 15/12/2025

Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works

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Dimitry Tegunov @dtegunov.bsky.social · 13/12/2025

Don't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency

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Dimitry Tegunov @dtegunov.bsky.social · 18/11/2025

I'm not superstitious but I never set my TV's volume to 13

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Dimitry Tegunov @dtegunov.bsky.social · 29/10/2025

I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic

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Dimitry Tegunov @dtegunov.bsky.social · 18/10/2025

Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.

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Dimitry Tegunov @dtegunov.bsky.social · 10/10/2025

OMG they will go so well with my Bliss ugly Christmas sweater

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Dimitry Tegunov @dtegunov.bsky.social · 04/10/2025

It took me several weeks to notice how perfect this arrangement was

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Dimitry Tegunov @dtegunov.bsky.social · 25/09/2025

The things Apple will do to procrastinate improving Siri

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Dimitry Tegunov @dtegunov.bsky.social · 24/09/2025

Ugh, I'm starting to get spam texts with em dashes

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Reposted by Dimitry Tegunov

Guenter Resch @nexperion.net · 23/09/2025

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026

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Dimitry Tegunov @dtegunov.bsky.social · 23/09/2025

The North Bay is so packed with Porsches that the non-Porsches (Norsches?) are the real exotics there

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Dimitry Tegunov @dtegunov.bsky.social · 13/09/2025

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

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Dimitry Tegunov @dtegunov.bsky.social · 15/08/2025

K-Pop Demon Hunters OST playing on the radio? Cool!

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Dimitry Tegunov @dtegunov.bsky.social · 07/08/2025

I just found out the latest version of MacOS finally implements the motion cue dots iOS has had for a few years now, and it's doing wonders for me when I need to use my laptop on bus rides

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Dimitry Tegunov @dtegunov.bsky.social · 01/08/2025

I don't know what cursed token sequence puts Claude into stupid mode, but it's impossible to recover from it and you have to start a new conversation

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Dimitry Tegunov @dtegunov.bsky.social · 01/07/2025

Whoever gets the resolution of raw tomograms to <10 Å within the sampled parts of Fourier space would probably deserve a Nobel. Or they'd get one anyway for the crazy new physics they discovered to achieve that.

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Dimitry Tegunov @dtegunov.bsky.social · 31/05/2025

I had a dream last night where some online store had the 5090 FE in stock at MSRP. It was a happy dream 🥹

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Dimitry Tegunov @dtegunov.bsky.social · 24/05/2025

He's currently beta-testing “faucet with a sensor that doesn't register your hands until you bring them in the least fortunate position, then sends water full-blast horizontally at them to be deflected to your crotch area to make it look like you peed yourself” in select locations

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Dimitry Tegunov @dtegunov.bsky.social · 26/04/2025

Y'all marketing people need to stop handing out reusable water bottles at every event

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Dimitry Tegunov @dtegunov.bsky.social · 18/04/2025

Came for the memes, stayed for the science

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Dimitry Tegunov @dtegunov.bsky.social · 07/04/2025

I've got bad news for #teamtomo: earlier today, our resident headcrab attacked @lorenzlamm.bsky.social, turning his Mem🧠 into 🧟‍♂️🧠

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