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Structura Biotechnology @structurabio.bsky.social · 11h

Are you looking for another opportunity to learn #SingleParticle #cryoEM? Instruct.SI is organizing a workshop covering cryo-EM from grid preparation to 3D reconstruction! 👀 Check out their website for more information - registration deadline October 2, 2026

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Structura Biotechnology @structurabio.bsky.social · 29/09/2026

🇨🇦 Last week, we wrapped up “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with #CryoSPARC” in Toronto! Thank you to all the #cryoEM scientists who joined us, and to @sickkidsto.bsky.social for another great collaboration! We already look forward to the next workshop! Stay tuned!

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Structura Biotechnology @structurabio.bsky.social · 24/09/2026

🇨🇦 Today we kicked off our hands-on workshop, “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with CryoSPARC,” in collaboration with The Hospital for Sick Children @sickkidsto.bsky.social! Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬

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Structura Biotechnology @structurabio.bsky.social · 23/09/2026

🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification? "Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views. Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0

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Structura Biotechnology @structurabio.bsky.social · 16/09/2026

🚀 Register now for the 2026 Stanford-SLAC CryoEM Center (S2C2) Data Processing Workshop, December 9-11! We’re excited to contribute as #CryoSPARC instructors to this hybrid workshop, together with instructors from CryoDRGN, EMAN2 and AreTomo! More info and registration 👉 bit.ly/4gXbnXd

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Structura Biotechnology @structurabio.bsky.social · 10/09/2026

💡 The idea is simple: getting to know your data is often the shortcut to more efficient particle picking. In our latest #CryoSPARC blog post, we cover how to speed up #cryoEM data processing through efficient early curation of your dataset. 👉 cryosparc.com/blog/curatio...

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Structura Biotechnology @structurabio.bsky.social · 03/09/2026

🚀 Next week we will be at the 2026 New England #Cryo-EM Symposium at MIT, showcasing recent #CryoSPARC developments. If you're attending, we'd love to connect! cryoem.mit.edu/2026-ne-cryo...

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Structura Biotechnology @structurabio.bsky.social · 01/09/2026

💊 The Pain Paradox: Activating TRPV1 to Silence Its Response - Researchers leveraged rational drug design, functional experiments, and #cryoEM to characterize a new capsaicin-inspired TRPV1 agonist with prolonged analgesic effects. Read more in the #CryoSPARC Blog 👉 cryosparc.com/blog/trpv1-m...

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Structura Biotechnology @structurabio.bsky.social · 27/08/2026

🛠️ Even the most carefully managed IT environments need to be prepared for the unexpected. In #CryoSPARC v5, we introduced Instance Recovery, a built-in recovery system for unforeseen database loss or corruption, adding another layer of resilience to our #cryoEM software. Read more 👉 bit.ly/4xlZMGS

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Structura Biotechnology @structurabio.bsky.social · 25/08/2026

📽️ Did you miss our talk at the Spring CCP-EM Symposium 2026? You can now watch the full talk from Structura, where we share some of the latest and upcoming developments in #CryoSPARC and single-particle #cryoEM: Check out the full talk here 👇 www.youtube.com/watch?v=Rilg...

youtube.com

New Developments for Single Particle Cryo-EM Data Processing in CryoSPARC | Ali Punjani (Structura)

YouTube video by CCP-EM

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Structura Biotechnology @structurabio.bsky.social · 20/08/2026

🔬Malaria Invasion at Molecular Resolution: From Protein Inhibitors to Membrane Remodeling In a recent Cell publication, researchers at Columbia University resolved the endogenous structure of the malaria moving junction staple using #cryoEM. Read more in the #CryoSPARC Blog 👉 bit.ly/46aX6jl

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Structura Biotechnology @structurabio.bsky.social · 17/08/2026

🚀 Preprint alert: cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle #CryoEM Explore how cFAR, tFAR, and Relative Signal provide complementary diagnostics for preferred orientation, tested across 14 #EMPIAR datasets and compared with established metrics 👉 bit.ly/4wBY1Ev

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Structura Biotechnology @structurabio.bsky.social · 13/08/2026

🔄 Mixing Two Cryo-EM Datasets on Purpose: A Cryo-EM Heterogeneity Challenge What happens when you deliberately mix two #cryo-EM datasets containing different conformational states? Our latest #CryoSPARC blog distills the practical lessons from the accompanying FaNaC1 case study 👉 bit.ly/3ScIZa3

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Structura Biotechnology @structurabio.bsky.social · 10/08/2026

🇨🇦 This week we’re at IUCr 2026 in Calgary! Join us during Poster Session 4B (Sunday 15th, 5-6 PM MDT), at poster #486, where we’ll be presenting: 🔹 Updates and upcoming developments in #CryoSPARC 🔹 Advances in automated #cryo-EM data processing 👉 www.iucr2026.org

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Bui Lab @McGill @builab.bsky.social · 04/08/2026

Introducing CsMT: A new CryoSPARC workflow for high-resolution microtubule reconstruction based on novel PF-pair classification! You can reconstruct MTs entirely in CryoSPARC—zero custom scripts needed. Inspired & built through a fantastic collaboration with the Cianfrocco lab! tinyurl.com/kdpm86tw

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Structura Biotechnology @structurabio.bsky.social · 03/08/2026

✨ We’re at the Microscopy & Microanalysis conference in Milwaukee (WI) this week! Join us during session B04.2, where we’ll be showcasing recent #CryoSPARC developments and discussing the latest advances in single-particle #cryoEM data processing and analysis. 👉 mmconference.microscopy.org

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Structura Biotechnology @structurabio.bsky.social · 30/07/2026

🔬 Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis! Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin

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Structura Biotechnology @structurabio.bsky.social · 27/07/2026

✨ We’ll be at the Structure-Based Drug Design Summit in Boston this week, showcasing recent #CryoSPARC developments for industrial applications in #cryoEM and #SBDD. If you're attending, we'd love to connect! structure-based-drug-design-summit.com

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Structura Biotechnology @structurabio.bsky.social · 23/07/2026

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG

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Structura Biotechnology @structurabio.bsky.social · 21/07/2026

🧩 Why can two refinements with very different particle counts produce nearly identical maps? Our new “Digging Deeper” series breaks down #CryoSPARC case studies in a practical way, starting with how refinement parameters shape reconstruction quality. Read more 👉 cryosparc.com/blog/paramet...

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Structura Biotechnology @structurabio.bsky.social · 20/07/2026

A reminder that registration closes on July 24th!

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Structura Biotechnology @structurabio.bsky.social · 16/07/2026

🚀 New and expanded #CryoSPARC Guide pages are here! 📚 We present to you several new and updated pages, featuring new figures and explanations, along with learning materials designed for both new and advanced #cryoEM practitioners. Brief summary of what’s new in the thread!

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Structura Biotechnology @structurabio.bsky.social · 14/07/2026

✉️ The latest #CryoSPARC Newsletter is out! Highlights include: 🔹 Sept 2026 workshop hosted with SickKids 🇨🇦 🔹 New cryosparc-tools video 🔹 New case study on discrete heterogeneity 🔹 Small-protein #cryoEM advances 🔹 Dynamic masking guide (v5) Read more here: mailchi.mp/b8fb173dac5c...

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Structura Biotechnology @structurabio.bsky.social · 08/07/2026

🔬Using #SingleParticle #cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction organization and function. Read more in the latest #CryoSPARC Blog 👉 cryosparc.com/blog/gap-jun...

cryosparc.com

CryoSPARC | Mind The Gap: Cryo-EM Reveals Lipids Intercalating Connexin Assemblies

Using single particle cryo-EM on plaque-mimicking nanodiscs, researchers determined multiple connexin assembly states and uncovered lipid-protein interactions that may help understand gap junction org...

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Structura Biotechnology @structurabio.bsky.social · 06/07/2026

🇨🇦 The Toronto-based #CryoSPARC Workshop in collaboration with SickKids is back this September! Dive deep into single particle data processing with the experts at Structura. 🗓️ When | Sept 24-25, 2026 📍Where | SickKids Patient Support Centre, Toronto Info and registration: cvent.me/dL1wem #cryoEM

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John Rubinstein @johnrubinstein.bsky.social · 06/07/2026

CryoSPARC workshop in Toronto! Beyond consensus refinements: Advanced cryo-EM data processing with CryoSPARC Sept 24-25, 2026 (part of the Canadian Cryo-EM Nexus) Register here: cvent.me/dL1wem Please see details in the link or the image Alt text @structurabio.bsky.social @sickkidsto.bsky.social

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Structura Biotechnology @structurabio.bsky.social · 30/06/2026

☀️ Last week we had the pleasure of contributing to the UCSC #CryoEM Workshop in Santa Cruz with a hands-on #CryoSPARC data processing session. ✨ Thank you to the organizers and everyone who participated. We look forward to many more opportunities to contribute to workshops like this!

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Structura Biotechnology @structurabio.bsky.social · 25/06/2026

🚀 Can automation scale #cryoEM? We recently demonstrated it is possible to make #cryo-EM more routine and scalable testing across 21 challenging #GPCR datasets, a real-world scenario for #SBDD, achieving results equal or better than manual processing. Read more 👉 cryosparc.com/blog/automat...

cryosparc.com

CryoSPARC | Automated Workflows in CryoSPARC™

How to make use of one-click, automated data processing workflows that can provide equal or better results as manual processing

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Structura Biotechnology @structurabio.bsky.social · 23/06/2026

☀️ Structura will be at the UCSC CryoEM Workshop in Santa Cruz this week, leading a hands-on workshop on #cryoEM #SingleParticleAnalysis with #CryoSPARC. Looking forward to exchanging ideas and strategies, and chatting about all things cryo-EM! See you there!🔬 👉 sites.google.com/view/ucsccry...

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Structura Biotechnology @structurabio.bsky.social · 16/06/2026

In a recent #NatComm study, researchers leveraged high-resolution #cryoEM structures of the κ-opioid receptor bound to difelikefalin to guide the design of a more selective compound with reduced side-effect potential. 👉 cryosparc.com/blog/kor-sbdd #StructuralBiology #SBDD #CryoSPARC

cryosparc.com

CryoSPARC | Scratching Beneath the Surface: Cryo-EM Guides New Opioid Drug Design

Cryo-EM revealed the molecular basis of KOR signaling bias, enabling structure-based drug design of an anti-pruritic peptide with reduced side effects.

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Structura Biotechnology @structurabio.bsky.social · 09/06/2026

🔍 Sample heterogeneity is both a challenge and an opportunity in #cryoEM data processing. In our latest #CryoSPARC case study we explore EMPIAR-10927, a dataset with acetogenin-bound mitochondrial Complex I, that reveals many more complexes according to the data processing strategy 👉 bit.ly/4uihh8V

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Case Study: Discrete heterogeneity in a sample of Acetogenin-bound complex I (EMPIAR 10927) | CryoSPARC Guide

Processing EMPIAR-10927 including separating targets using Per-particle scales or custom settings in Ab-Initio Reconstruction, and using 3DVA to guide sub-classification choices.

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Structura Biotechnology @structurabio.bsky.social · 05/06/2026

🦠 How does the human immune system defeat measles? #cryoEM and #CryoSPARC reveal the answer. 🔬 A recent study from @lji.org provides new insights into how the human immune system recognizes and neutralizes measles virus. Read more in the latest #CryoSPARC Blog 👉 cryosparc.com/blog/measles

cryosparc.com

CryoSPARC | A New Step in the Fight Against Measles

How Cryo-EM allows a closer look at the Human neutralizing antibodies targeting the measles virus

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Structura Biotechnology @structurabio.bsky.social · 02/06/2026

For years, the #cryoEM community viewed ~50 kDa as the practical lower size limit for SPA. This was challenged by Kim et al., who introduced the HR-HAIR method and demonstrated structure determination of proteins below 30 kDa using #CryoSPARC. Read more 👉 bit.ly/3RHMxAt

bit.ly

CryoSPARC | The Resolution Revolution Is Still Ongoing

High-Resolution Ab-Initio Reconstruction: Extending Cryo-EM to Smaller Particles with CryoSPARC™

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Structura Biotechnology @structurabio.bsky.social · 27/05/2026

🚀 We're excited to announce the stable release of CryoSPARC v5! After a successful public beta and months of testing, we’re excited to share this major milestone, made possible by feedback from the amazing #CryoSPARC community. Learn more 👉 cryosparc.com/blog/v5-0-st... #cryoEM #StructuralBiology

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Structura Biotechnology @structurabio.bsky.social · 25/05/2026

🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!

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Structura Biotechnology @structurabio.bsky.social · 21/05/2026

cryosparc-tools is a standalone Python library that connects to #CryoSPARC and is designed to advance your #cryoEM data processing via scripting. 🚀 Watch this new video for an overview of cryosparc-tools, and explore the resources linked in the description 👉 youtu.be/QY7t67c9bQ8

youtu.be

CryoSPARC Tools: Simple scripting for advanced cryo-EM processing

YouTube video by Structura Biotechnology Inc.

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EMBL-EBI @ebi.embl.org · 18/05/2026

What is the value of open data for the life sciences? 📈 New report by Frontier Economics shows that EMBL-EBI data resources save users an average of 11 hours/week/person, leading to £11.8bn/year in research productivity gains. s.embl.org/EMBL-EBI-202... #opendata

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Structura Biotechnology @structurabio.bsky.social · 15/05/2026

What an incredible #Cryo-EM SPA mini-course last week, hosted by @royalmicrosoc.bsky.social & ThermoFisher Scientific! 🚀 Huge thanks to all the participants who joined the webinar, and to the experts who shared their insights on #SingleParticle #cryoEM workflows.

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Dawid Zyla @dzyla.bsky.social · 07/05/2026

Measles is coming back. Until now, we didn't know how human antibodies actually recognize and neutralize the virus. No structure of either measles surface protein bound to a human antibody had ever been reported. We set out to change that.

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Structura Biotechnology @structurabio.bsky.social · 07/05/2026

We will be at the @proterosma.bsky.social IBA Conference in Boston next week! Stop by our poster to chat about the latest developments in #CryoSPARC, including new results from fully automated data processing for #sbdd repeat-target scenarios & v5 features 🔬 bit.ly/49hQoKo #SingleParticle #Cryo-EM

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Structura Biotechnology @structurabio.bsky.social · 05/05/2026

Last week we had our #CryoSPARC Workshop in collaboration with the Hospital for Sick Children (SickKids) in Toronto 🇨🇦 It was a pleasure to meet all the wonderful participants and learn from each other! We’re looking forward to future #cryoEM workshops! 🚀

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Structura Biotechnology @structurabio.bsky.social · 27/04/2026

🔬After learning how to collect #cryoEM data, this final webinar shows how data processing can unlock the highest-resolution insights possible. Join us for Part 3 of the Cryo-EM SPA mini-course with @royalmicrosoc.bsky.social & ThermoFisher Scientific — register now! 🗓️ May 5 👉 bit.ly/4cdEnrr

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Thermo Fisher Scientific Cryo-EM SPA introductory mini-course (14 April, 21 April & 5 May)

Learn the fundamentals of cryo-EM Single Particle Analysis (SPA) in this Cryo-EM Essentials introductory mini-course.

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Structura Biotechnology @structurabio.bsky.social · 23/04/2026

We are at the CCP-EM Spring Symposium XII in Nottingham! Come check out our talk (Session 6, 11:00) and Poster 12 (Session 1) to stay updated on new developments for #SingleParticle #Cryo-EM Data Processing in #CryoSPARC!

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Structura Biotechnology @structurabio.bsky.social · 16/04/2026

Part 1 was just the beginning 🚀 After the Cryo-EM SPA mini-course kickoff with @royalmicrosoc.bsky.social & ThermoFisher Scientific, don’t miss: 🗓️ Apr 21: Data Collection 🗓️ May 5: Data Processing (with Structura Biotechnology) Register 👉 bit.ly/4cdEnrr #cryoEM #CryoSPARC

bit.ly

Thermo Fisher Scientific Cryo-EM SPA introductory mini-course (14 April, 21 April & 5 May)

Learn the fundamentals of cryo-EM Single Particle Analysis (SPA) in this Cryo-EM Essentials introductory mini-course.

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clairesnaylor.bsky.social @clairesnaylor.bsky.social · 14/04/2026

High-resolution reconstructions don’t come from “more data” – they come from better data. Join us for Webinar 2 (Data Collection) in our Cryo-EM SPA introductory mini-course, with the Royal Microscopical Society. 🗓️ April 21, 2026 | 6 pm BST ✅ Register once for access to all sessions: ter.li/pksdqb

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Royal Microscopical Society @royalmicrosoc.bsky.social · 23/03/2026

Book now for the Thermo Fisher Scientific Cryo-EM SPA introductory mini-course (14 April, 21 April & 5 May) - FREE online webinar series featuring lectures, Q&A and interactive, virtual break-out rooms 🙂 🔬 Book now (FREE): ow.ly/ApaU50YxIf5

Close-up of a DNA double helix model with event details for Thermo Fisher Scientific's Cryo-EM SPA mini-course in April and May 2026.

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MiTeGen @mitegen.com · 23/03/2026

The 1st UCSC Cryo-EM Workshop - an intensive, hands-on program dedicated to Single Particle Analysis (SPA) will take place June 23–26 at the UCSC Biomolecular Cryo-EM Facility in Santa Cruz, California - Registration closes April 10th - Learn More -> zurl.co/FE5a4

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Brian Cook @bcryo.bsky.social · 23/03/2026

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

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clairesnaylor.bsky.social @clairesnaylor.bsky.social · 20/03/2026

SPA success is won (or lost) before you sit down at the microscope. Join Thermo Fisher Scientific and the Royal Microscopical Society for Webinar 1 of a free, 3-part Cryo-EM SPA introductory mini-course – focused on SPA Sample Preparation. 🗓️ April 14, 2026 | 6 PM BST Register now: ter.li/pksdqb

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Jennifer Cash @jencash.bsky.social · 20/03/2026

At the #cshlcourses cryo-EM course, Rich Waldo from @structurabio.bsky.social gave us a tutorial on cryoSPARC and did a fabulous job! I was honored to be used for an Einstein from noise demo.

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