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Wiseman Lab

@wisemanlab.bsky.social
410 followers 89 following 8 posts

Official BlueSky Account of Luke Wiseman's Lab at Scripps Research. For our research interests please visit our website @ wiseman.scripps.edu. Posts by Luke.

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Reposted by Wiseman Lab
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 05/09/2026
Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4+ TH17 Cells www.biorxiv.org/content/10.64898/20…
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Liz Miller @lizmillercu.bsky.social · 24/08/2026
*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...
jobs.ac.uk
Postdoctoral Research Assistant - UOD2336 at University of Dundee
Discover an exciting academic career path as a Postdoctoral Research Assistant - UOD2336 at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
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Alejandra Mendoza @thepenkpanther.bsky.social · 19/08/2026
Our lab has a new preprint out! If you are interested in how viral infections reprogram maternal tissues to promote protection of offspring after birth, take a look! www.biorxiv.org/content/10.6...
biorxiv.org
Maternal antiviral history synergizes with pregnancy and lactation to transfer intergenerational systemic immunity through IgG in milk
Maternal immune transfer is essential for early-life health, yet whether immune experiences before pregnancy shape maternal physiology to optimize immunity in subsequent offspring is unclear. Here, we...
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Wiseman Lab @wisemanlab.bsky.social · 19/08/2026
Check out this new preprint from Nancy Cheong, a joint student with @thepenkpanther.bsky.social . No idea how I got involved with this project but it sure was fun ‘being in the room where it happened’ with those two rock stars! www.biorxiv.org/content/10.6...
biorxiv.org
Maternal antiviral history synergizes with pregnancy and lactation to transfer intergenerational systemic immunity through IgG in milk
Maternal immune transfer is essential for early-life health, yet whether immune experiences before pregnancy shape maternal physiology to optimize immunity in subsequent offspring is unclear. Here, we...
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Danielle Grotjahn @nanigrotjahn.bsky.social · 16/06/2026
Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane
sciencedirect.com
Think globally, act locally: Redefining organellar membrane environments through cryo-electron tomography
Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…
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Giordano Lippi @lippilab.bsky.social · 07/04/2026
The Lippi lab is hiring a postdoctoral associate! We built new technologies to study post-transcriptional regulation in the healthy and diseased brain. We are recruiting motivated and talented scientists who will use these tools to discover new biology and new therapies.
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Jan-Hannes Schaefer @jhschaef.bsky.social · 07/04/2026
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
Blender Rendering of vitrified HA trimer with DM at the air-water interface
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Alejandra Mendoza @thepenkpanther.bsky.social · 01/04/2026
Excited to share that our lab’s first preprint is now available! This work reflects a huge effort from graduate student Abeera Mehmood and coauthors! If you are interested in what B cells make all antibodies against norovirus take a look! www.biorxiv.org/content/10.6...
biorxiv.org
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Guillaume Thibault @gthibault.bsky.social · 01/04/2026
We're hiring at NTU SBS, Singapore. Tenure-track faculty position in Biomedical Data Science (computational biology, AI in biology, bioinformatics). Great infrastructure, great place to do science. Please share. apply.ap1.interfolio.com/119013
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 25/03/2026
🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp
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Feyza Engin @enginlab.bsky.social · 26/03/2026
I’m excited to share that our review article, co-authored with my colleague Dr. Decio Eizirik, is out today in Science Translational Medicine. www.science.org/doi/10.1126/...
science.org
Beyond bystanders: How β cell stress shapes the autoimmune response in T1D
β cell stress not only drives loss of functional β cell mass but also may fuel autoimmunity in type 1 diabetes.
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 18/02/2026
Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling www.biorxiv.org/content/10.64898/20…
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bioRxivpreprint @biorxivpreprint.bsky.social · 03/02/2026
SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis www.biorxiv.org/content/10.64898/20…
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Wiseman Lab @wisemanlab.bsky.social · 18/02/2026
New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...
biorxiv.org
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Review Commons @reviewcommons.org · 11/12/2025
One review. Many journals. Less redundancy. Check out this conversation with our head Dr. Thomas Lemberger on the vision behind @reviewcommons.org and what it means for authors and journals alike @embopress.org @embo.org www.embo.org/people/revie...
embo.org
Review Commons: rethinking peer review – Features – EMBO
A conversation with Thomas Lemberger, lead of the Review Commons initiative and Head of Open Science Implementation at EMBO.
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 23/12/2025
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response www.biorxiv.org/content/10.64898/20…
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Danielle Grotjahn @nanigrotjahn.bsky.social · 22/12/2025
JCB’s Cover of the Year voting is open! I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬 #teamtomo @attychang.bsky.social
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Sam Lewis, Ph.D. @samlewis.bsky.social · 18/12/2025
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
biorxiv.org
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
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Wisconsin Institute for Discovery @widofficial.bsky.social · 17/12/2025
In collaboration with @enginlab.bsky.social, Khahani Eynullazada, a grad student from @sroyyors.bsky.social Lab identified gene regulatory networks capturing shared and perturbation-specific stress pathways in Type 1 diabetes using GRN inference tools on scRNA-seq data from in vivo mouse models.
news.wisc.edu
How disabling one gene protects mice against Type 1 diabetes
UW–Madison researchers have discovered a mechanism that could one day help people at risk of developing the metabolic disease.
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Eric (“VJ”) Rubenstein @vjrubenstein.bsky.social · 10/12/2025
If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium! Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz! @ascbiology.bsky.social
Schedule of speakers for the Endoplasmic Reticulum Minisymposium speakers on Dec 10 9-11 AM at the Cell Bio 2025 conference.
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Prasanna Satpute-Krishnan @pskcellbio.bsky.social · 06/12/2025
#CellBio2025 This Wednesday, Dec 10 at 9:00 AM in Room 122 Please add it to your schedule!
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Kirstein Lab @kirsteinlab.bsky.social · 04/11/2025
Postdoc position available in my lab in Jena (Germany. jobs.leibniz-fli.de/jobposting/6... If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
jobs.leibniz-fli.de
Postdoc (m/f/x)
Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...
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Wiseman Lab @wisemanlab.bsky.social · 02/10/2025
Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756
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Danielle Grotjahn @nanigrotjahn.bsky.social · 20/08/2025
🚨 #teamtomo!🚨 Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??
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Sam Lewis, Ph.D. @samlewis.bsky.social · 30/07/2025
Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!
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Wiseman Lab @wisemanlab.bsky.social · 27/06/2025
New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇 www.biorxiv.org/content/10.1...
biorxiv.org
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...
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PLOS Biology @plosbiology.org · 14/04/2025
TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5
During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.
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Danielle Grotjahn @nanigrotjahn.bsky.social · 09/04/2025
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social
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Ardem Patapoutian @ardemp.bskyverified.social · 09/04/2025
Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...
cnn.com
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
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Guillaume Thibault @gthibault.bsky.social · 02/04/2025
🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast! Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social #FASEB2025 #ERSRC
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Life Science Alliance @lsajournal.org · 04/04/2025
New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...
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Susan Logue @loguesusan.bsky.social · 09/03/2025
Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting. www.sciencedirect.com/science/arti...
sciencedirect.com
A BiP-centric view of endoplasmic reticulum functions and of my career
After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…
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Ardem Patapoutian @ardemp.bskyverified.social · 25/02/2025
OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs." www.sandiegouniontribune.com/2025/02/25/o...
sandiegouniontribune.com
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
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Susan Logue @loguesusan.bsky.social · 23/02/2025
Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social biomed.news/bims-unfpre/... biomed.news/bims-unfpre/... biomed.news/bims-unfpre/...
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Dana Shaw @shawlab.bsky.social · 10/01/2025
Very happy to share the latest preprint from my lab led by Kaylee Vosbigian @kaylee-vosbigian.bsky.social ! We found that Anaplasma activates the ATF6 branch of the unfolded protein response in Ixodes ticks to facilitate cholesterol uptake for growth and survival. #MicroSky #Anaplasma #ticks
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Wiseman Lab @wisemanlab.bsky.social · 02/01/2025
Excited to be involved in this cool project led by @yananchenlab.bsky.social and her team showing protection afforded by the ATF6 activator AA147 in a mouse model of multiple sclerosis. Check it out! 👇
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Keren Lasker @kerenlasker.bsky.social · 30/12/2024
1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
biorxiv.org
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
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Lander Lab @landerlab.bsky.social · 19/12/2024
A huge week for Prakhyat, our joint @scripps.edu student with the @wisemanlab.bsky.social! He was awarded an AHA earlier in the week and today he passed his PhD candidacy exam! Because Prakh is so chill, we celebrated with chocolate-coffee liquid nitrogen ice cream. 😎
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Lander Lab @landerlab.bsky.social · 17/12/2024
Congrats to our amazing @scripps.edu grad student Prakhyat Mathur (joint with @wisemanlab.bsky.social) for being awarded a predoctoral fellowship from the AHA @americanheart.bsky.social. Prakh will be investigating how mitochondrial stress activates the integrated stress response. Well-earned Prakh!
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Guillaume Thibault @gthibault.bsky.social · 11/12/2024
🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking. Check out the program and register here 👇 events.faseb.org/event/endoplasmic-reticulum-function-disease
events.faseb.org
Endoplasmic Reticulum
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