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Meseret Haile

@mehsehret.bsky.social
17 followers 23 following 0 posts
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Reposted by Meseret Haile
Trends in Parasitology @cp-trendsparasitol.bsky.social · 23/09/2026
Sailing to a deeper understanding of malaria parasite invasion
dlvr.it
Sailing to a deeper understanding of malaria parasite invasion
In a recent article by Haile et al., the atomic-level structure of the protein complex responsible for the invasion of the malaria parasite into red blood cells is described. Here, the key findings and the implications for the development of next-generation antimalarials are reviewed.
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Reposted by Meseret Haile
cryoEM papers @cryoempapers.bsky.social · 01/07/2026
Structural basis for host membrane binding and remodeling by invading malaria parasites pubmed.ncbi.nlm.nih.gov/42379167/ #cryoEM
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Reposted by Meseret Haile
Chi-Min Ho @cmholab.bsky.social · 30/06/2026
Finally, Messi teamed up with our newest student Daphne Kaxiras to explore a new avenue for antimalarial design. Using the structure as a guide, they used #BindCraft to design and validate a mini-protein binder that inhibits parasite invasion by blocking the formation of the moving junction! 🚫🦠
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Reposted by Meseret Haile
Chi-Min Ho @cmholab.bsky.social · 30/06/2026
The full structure of the AMA1-RON complex sheds light on ongoing efforts to develop antimalarials targeting parasite invasion, and reveals the first clues into how the moving junction works, pointing toward a massive molecular machine that actively remodels the host cell membrane during invasion!⚙️🗜️
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Reposted by Meseret Haile
Chi-Min Ho @cmholab.bsky.social · 30/06/2026
The moving junction only exists for the 60 sec it takes for a parasite to hijack a host cell, so Messi found a way to stall invading parasites on host cells and purified the native complex directly from invasion-stalled parasites for #Cryo-EM ❄️🔬The final structure looks a lot like a sailboat! ⛵
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Reposted by Meseret Haile
Chi-Min Ho @cmholab.bsky.social · 30/06/2026
Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬
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Reposted by Meseret Haile
Chi-Min Ho @cmholab.bsky.social · 20/10/2025
Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria
rdcu.be
Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator
Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...
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