iiinova — where your digital self keeps evolving

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Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

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joe dobbs @joedobbs.bsky.social · 25/09/2026

Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...

cell.com

Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries

Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/09/2026

A wild publishing ride to get here... but finally! (first bioRxiv: January 5th, 2024 🙃) Amazing work from @lorenzlamm.bsky.social and colleagues 🤗 Special thanks to the community who jumped early on the boat, sharing feedback and training data to make MemBrain v2 a reality 🙏🏽

nature.com

MemBrain v2: an end-to-end tool for the analysis of membranes in cryo-electron tomography - Nature Methods

MemBrain v2 enables streamlined analysis of membranes in cryo-electron tomography by providing user-friendly tools for membrane segmentation, membrane protein localization and spatial analysis, suppor...

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Reposted by Andrea Dallapè

mareikejordan.bsky.social @mareikejordan.bsky.social · 04/09/2026

Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...

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Denis Chrétien @dchretien.bsky.social · 28/08/2026

Dear #CryoEM and #Microtubule enthusiasts, I’m thrilled to have been part of this exciting journey: www.biorxiv.org/content/10.6... We discovered and characterized a manchette-like microtubule machinery in Xenopus spermatids, likely involved in sperm reshaping and membrane reorganization. (1/3)

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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/08/2026

Imaging large fields-of-view at high resolution in cryo-ET with square beam montaging www.biorxiv.org/content/10.64898/20…

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Tanmay Bharat @tbharat-lab.bsky.social · 23/08/2026

Molecular architecture of colossal surface layers from hyperthermophilic archaea Led by @idocaspy.bsky.social (Ido) In collaboration with @mkrupovic.bsky.social and @vikramalva.bsky.social labs doi.org/10.64898/202...

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Rhys Grinter @rhyswg.bsky.social · 18/08/2026

Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5

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Florent Waltz @florentwaltz.bsky.social · 27/07/2026

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

nature.com

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

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Nicholas Bellono @nbellono.bsky.social · 09/07/2026

How did octopuses evolve novel traits? Rishav Mitra, Richard Han, Trey Scott, et al serendipitously discover a unique ribosome adaptation that increases the accuracy of protein synthesis and evolved alongside their elaborate nervous systems vs deep sea relatives. www.biorxiv.org/content/10.6...

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Chi-Min Ho @cmholab.bsky.social · 30/06/2026

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

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Nogales Lab @nogaleslab.bsky.social · 29/06/2026

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

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Andrea Dallapè @daddea.bsky.social · 27/06/2026

That is clearly amazing. At this rate, how many years would it take for California to become 100% renewable? Is it feasible? (as a scientist, it’s incredible, considering the large number of research centers—electron microscopes, SLAC, etc.)

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Andrea Dallapè @daddea.bsky.social · 25/06/2026

Probably you just need some AI-based suggestion about what you’re searching on your wrist

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Plaschka lab @plaschkalab.bsky.social · 18/06/2026

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

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Reposted by Andrea Dallapè

Biohub @biohub.org · 16/06/2026

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

Diagram of FIB-SEM with integrated fluorescence microscope alongside cryo lamella micrograph and 3D segmentation highlighting targeted centrioles

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Reposted by Andrea Dallapè

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 06/06/2026

A Crossed Laser Phase Plate for CryoEM www.biorxiv.org/content/10.64898/20…

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arXiv q-bio.QM Quantitative Methods @qbioqm-bot.bsky.social · 01/06/2026

Muyuan Chen: Gaussian Mixture Model-Based Focused Refinement for Enhanced Flexible Structure Determination in CryoEM and CryoET arxiv.org/abs/2605.30518 arxiv.org/pdf/2605.30518 arxiv.org/html/2605.30518

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cryoEM papers @cryoempapers.bsky.social · 29/05/2026

The molecular architecture of tunneling nanotubes www.biorxiv.org/content/10.64898/2026.05.27.728322v1 #cryoEM

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Cell Press @cellpress.bsky.social · 29/05/2026

"Mitochondria-lysosome coupling contributes to lysosome acidification and aging" Read more in Molecular Cell: www.cell.com/molecular-ce... Chuankai Zhou & colleagues @cp-molcell.bsky.social

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cryoEM papers @cryoempapers.bsky.social · 22/05/2026

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging www.biorxiv.org/content/10.64898/2026.05.19.726344v1 #cryoEM

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Maria Barna @mbarnalab.bsky.social · 21/05/2026

’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

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Andrea Dallapè @daddea.bsky.social · 15/05/2026

It undergoes to a quite funny movement during initiator tRNA recognition -hopefully out soon

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Higor Rosa @hvdrosa.bsky.social · 14/05/2026

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

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Bram Verhagen @bramverhagen.bsky.social · 13/05/2026

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

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cryoEM papers @cryoempapers.bsky.social · 24/04/2026

Interleaved multi-magnification cryo-electron tomography bridges cellular and structural biology www.biorxiv.org/content/10.64898/2026.04.21.719848v1 #cryoEM

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Sylvie Callegari @sylviecallegari.bsky.social · 06/04/2026

Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535

seek.com.au

Biochemist/Cell Biologist Research Officer Job in Parkville, Melbourne VIC - SEEK

An excellent opportunity is available for a Research Officer / Senior Research Officer to join the Callegari Lab at WEHI.

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Bui Lab @McGill @builab.bsky.social · 12/04/2026

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

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Debnath Ghosal @debnathghosal.bsky.social · 12/04/2026

One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶‍♂️

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 07/04/2026

Molecular architecture of the ciliary base in mammalian multiciliated cells www.biorxiv.org/content/10.64898/20…

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Jan-Hannes Schaefer @jhschaef.bsky.social · 07/04/2026

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Blender Rendering of vitrified HA trimer with DM at the air-water interface

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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

youtube.com

Cryo-EM structure of yeast telomerase

YouTube video by MRC Laboratory of Molecular Biology

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Reposted by Andrea Dallapè

Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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Sjors Scheres @sjorsscheres.bsky.social · 18/03/2026

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

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Andrea Dallapè @daddea.bsky.social · 02/03/2026

If you can, I would suggest you to search for “pasta dei cornuti” (literally, “pasta of the cheated husbands”). You would get some important and interesting insights about the recipe’s tradition -in Italy, at least

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Andrea Dallapè @daddea.bsky.social · 20/02/2026

From what I remember (very little) was from wheat germ lysate, but yes, it was not in cells

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cryoEM papers @cryoempapers.bsky.social · 19/02/2026

The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior pubmed.ncbi.nlm.nih.gov/41706843/ #cryoEM

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Andrea Dallapè @daddea.bsky.social · 20/02/2026

Oh, I remember that one, it was nice! Or a paper from Spirin, a NAR from 2016 I guess?

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · 17/02/2026

Pulsed #lasers integrated with #cryoEM: @fitzpatricklab.bsky.social postdoc Daniel Du aims to boost contrast in #cryoET zuckermaninstitute.columbia.edu/making-world-s-best-microscopes-biology-better zuckermaninstitute.columbia.edu/science-life-daniel-du elifesciences.org/reviewed-preprints/109793v1

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cryoEM papers @cryoempapers.bsky.social · 19/02/2026

Integrase anchors viral RNA to the HIV-1 capsid interior pubmed.ncbi.nlm.nih.gov/41708858/ #cryoEM

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