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joe dobbs

@joedobbs.bsky.social
208 followers 214 following 23 posts

structural cell biologist 🇨🇦 @mpibrain

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Reposted by joe dobbs
EMBL @embl.org · 26/09/2026
EMBL scientists uncovered new interactions between molecular machines directly inside cells. With cryo-ET, they gleaned new aspects of bacterial protein production, transport, and folding in cells – and a new way to analyse ‘communities’ of molecular machines. www.embl.org/news/science...
embl.org
The bustling molecular communities inside cells | EMBL
New research illuminated mechanisms of bacterial protein production, transport, & folding, while better understanding molecular communities.
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joe dobbs @joedobbs.bsky.social · 25/09/2026
Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...
cell.com
Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries
Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...
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Reposted by joe dobbs
Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026
🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET
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Reposted by joe dobbs
IMP @impvienna.bsky.social · 15/09/2026
Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2026! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...
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Reposted by joe dobbs
EMBL @embl.org · 20/07/2026
EMBL and University of Washington researchers have developed NovoTags – AI-designed protein tags – that in future could help researchers combine fluorescence microscopy and cryo-ET, helping identify individual proteins inside cells. @steffenklein.bsky.social More info 👉 www.embl.org/news/science...
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joe dobbs @joedobbs.bsky.social · 03/06/2026
Super cool cryo-ET work from my colleague Xiaohan resolving a ton of ribosome assembly intermediates in the nuclei of human cells!
Figure 4 from the preprint
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Reposted by joe dobbs
Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:
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joe dobbs @joedobbs.bsky.social · 22/04/2026
Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...
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joe dobbs @joedobbs.bsky.social · 14/04/2026
We @embl.org wrote a short preprint about optimizing for maximum completeness in #cryoet analysis. We looked at template matching, VPP imaging, and tilt-series refinement parameters, and why averaging ribosomes helps even if you aren’t interested in their biology 🏭 www.biorxiv.org/content/10.6...
Figure 4 from the preprint
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joe dobbs @joedobbs.bsky.social · 25/12/2025
Really excellent work by the bluesky-less Marie and Sara +coauthors in our lab @embl.org! Check it out for cool combinations of light microscopy and #cryoET, and if you're interested in how yeasts reorganize structurally in response to stressors. #teamtomo
Figure 2 from the paper. A cool combination of subtomogram averaging and light microscopy to investigate fatty acid synthase across species.
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Reposted by joe dobbs
EMBL @embl.org · 11/12/2025
Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis
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joe dobbs @joedobbs.bsky.social · 15/10/2025
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️ www.biorxiv.org/content/10.1... #teamtomo
Figure 1 from the preprint
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Reposted by joe dobbs
Jenny Sachweh @jennysachweh.bsky.social · 18/08/2025
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
sciencedirect.com
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
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joe dobbs @joedobbs.bsky.social · 19/07/2025
New paper from my colleague Soheil in the Mahamid and @jonasries.bsky.social groups looking at factors influencing laser devitrification on frozen #cryoem samples. With a far-red fluorophore, all-gold support grids will be especially good for correlative cryo-SMLM and EM! doi.org/10.1016/j.js...
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Reposted by joe dobbs
Rasmus Jensen @rasmusjensen.bsky.social · 28/04/2025
Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work: www.biorxiv.org/content/10.1... Thank you to all coauthors for your amazing work!
biorxiv.org
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