bioRxiv Biophysics @biorxiv-biophys.bsky.social · 1hThe biophysical interaction network that couples zona occludens-1 to membrane proteins at tight junctions www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 1hAsymmetric assembly underlies activation mechanism of neuronal GIRK1/2 channels www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 8hChameleonicity Beyond Compactness: Conformational Persistence and Passive Permeability Across 20 PROTAC Ensembles www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9hUnraveling phenotypic variation in multiscale behavioral dynamics www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9hLipid Defect Analyzer (LipiDeA): A Python Framework for Quantifying Lipid Packing Defects in Curved and Neutral Lipid-Containing Membranes www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9hJoint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9hBilayer-bound structure of SARS-CoV-2 Envelope protein in complex with a host PDZ domain www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 9hSubstrate accessibility of bovine milk proteins to a Pseudomonas metalloprotease reveals why caseins are more readily hydrolysed than whey proteins www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 11hActivation thresholds set the speed of biochemical trigger waves www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 13hAre carbohydrate ring distortions determined by biology or crystallography? The impact of experimental conditions on structural data www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 13hDanuglipron and orforglipron engage GLP-1R through materially different interfaces: an unbiased molecular dynamics study www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 15h4D confocal microscopy of time dependent cell and nuclear osmotic response reveals differential osmoregulation and transport kinetics www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 23hMechanophenotype of synovial fibroblasts correlates with patients' pathotypes and treatment response in Rheumatoid Arthritis www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 06/10/2026bioRheoFlow A Rheometric Platform for In Situ Biofilm Mechanics Under Controlled Flow Conditions www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 06/10/2026Electrode-Tethered DNA: Interfacial Mechanics and Switching Dynamics from Ensemble-Level Atomistic Simulations www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Metabolic cost sets the shear stress profile of optimal vascular trees www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Polyglutamine aggregation proceeds by stochastic nucleation in the C. elegans nervous system www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Structural basis of selective phospholipid recognition and local membrane deformation by CTL1 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Shear Strain Stiffening in Cartilage is Governed by a Mechanical Phase Transition www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Cellular Density Homeostasis Is Governed by an Anisotropic Attractor and Predictive Feedback Control www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Interplay of mechanics, growth and viral infection dynamics in a spatially expanding bacterial colony www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026A Kiss-and-Ride Mechanism for Lipid Exchange at Membrane Contact Sites www.biorxiv.org/content/10.64898/20… 022
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026State-selective nanobodies to probe Guanylate-binding protein coat assembly and function www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Red states modulate energy localization between the antenna and trap in PSI www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Generating Structural Ensembles of Disordered Proteins with Diffusion Models www.biorxiv.org/content/10.64898/20… 032
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026A Nanomechanical Fingerprint of Centromeric Methylation Co-Localization in TNBC Chromosomal Instability www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Plunge freezing tweezers with ultrasonic excitation for reducing preferred particle orientation in cryo-EM www.biorxiv.org/content/10.64898/20… 033
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Complex folding kinetics of multi-domain proteins disentangled with periodic forces by magnetic tweezers www.biorxiv.org/content/10.64898/20… 011
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Conformational dynamics of ND2 antiporter-like subunit in intact and truncated complex I www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Integrating cell-state and enhancer constraints discriminates models of PU.1 regulation during hematopoietic differentiation www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Gag proteolysis drives HIV-1 envelope conformational closure through the gp41 cytoplasmic tail www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 05/10/2026Torque-optimized body morphing enables rapid surface to underwater diving in whirligig beetles www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Simulating Bead-Tethered Biomolecules: Force-Probe Coupled Steered Molecular Dynamics (fp-SMD) in Optical Tweezers Force Spectroscopy www.biorxiv.org/content/10.64898/20… 021
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Multi-Chain Hamiltonian Replica Exchange Framework for Probing Transient Helices and Order-Disorder Transitions in Proteins www.biorxiv.org/content/10.64898/20… 021
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026pH-sensitive binder design with Proton-PottsMPNN www.biorxiv.org/content/10.64898/20… 020
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer's disease www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Network analysis of correlated conformational dynamics across the evolution of influenza A virus NS1 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026SMartini: automated small molecule parametrization for Martini 3 force field www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Core NHEJ Factors Maintain Synapsis Across Diverse DNA End Structures www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026SOP-Multi-π: A Two-Site Coarse-Grained Model with Rescaled Aromatic Interactions to Bridge Single-Chain Ensembles and Condensate Phase Behavior of IDPs and Multidomain Proteins www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026Long-range transport of biomolecular condensates by Marangoni effect www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 02/10/2026A Dynamics-Informed Machine Learning Framework for Inhibitor Optimization Against Quickly Evolving Targets to Avoid Resistance www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026The molecular structural basis of the braking action of muscle www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026Sequential Design of Experiments enables accessible and efficient multidimensional mapping of single- and multi-protein condensates www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026Structural basis of phosphatidylserine enhancement of Gas6 ligand-induced Axl activation www.biorxiv.org/content/10.64898/20… 021
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026Active Nucleosome Sliding, Eviction, and Reassembly Dynamics Can Regulate Chromatin Condensate Organization www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026Physics and Morphology Constrained Quantitative Susceptibility Based Segmentation of Cerebral Veins www.biorxiv.org/content/10.64898/20… 010
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026Molecular determinants of ligand recognition and efficacy in the TRPM3 voltage sensor-like domain www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026From Ligand Binding to Pore Opening in the Mosquito Odorant Receptor AaegOR10 www.biorxiv.org/content/10.64898/20… 000
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 01/10/2026A refined sticker-spacer grammar marks disordered regions with interpretable pathogenic missense variation www.biorxiv.org/content/10.64898/20… 000
