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bioRxiv Molecular Biology

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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 11h
Preservation of intracellular protein-protein interactions in archived cytological specimens: Optimization of preanalytical variables for in situ proximity ligation assay www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 12h
A genome-wide CRISPR knockout screen identifies host dependency factors and potential viral-induced cell death regulators for porcine deltacoronavirus infection www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 12h
Stoichiometry-dependent gating and structural pharmacology of cardiac GIRK1/4 channels www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 12h
Comparative proteomic quantification reveals novel longevity regulators www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 17h
3D MERFISH reveals cell-type diversity generated by mRNA partitioning in spiralian embryogenesis www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 18h
Exitron-type splicing of intrinsically disordered regions recurs across jawed vertebrates despite sequence divergence: donor-proximal cis control in TARDBP www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 23h
Phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
Integrating single-cell and bulk transcriptomes identifies neuronal heat-stress-associated candidate genes in a reef-building coral www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
Development of a NanoBRET assay platform to detect intracellular target engagement in living cells for the Glycine Transporter 1 (SLC6A9) www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
HIV-1 Ribonucleoprotein Complex Organization Facilitates Assembly of the Mature HIV-1 Capsid www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
A direct RNA sequencing workflow for simultaneous profiling of tRNA abundance and modifications in mouse liver www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
Interferon-induced OASL restricts ADAR1 p150 RNA binding and A-to-I RNA editing www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
HIV-1 Assembly is Assisted by IRSp53 Through an Interaction that Extends Gag Conformation www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
RBM25 exhibits distinct RNA- and chromatin-associated target programs in human embryonic stem cells www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
Metatranscriptomic Identification of Co- and Incidental Infections in Marine Turtles Reveals Complex Disease Aetiologies www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 06/10/2026
Lactate epigenetically shapes tumor cell states in H3K27M diffuse midline gliomas www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
Promoter-targeted duplex RNAs activate TCF4 expression www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
A Structural Model of Transcriptional Activation by Mediator www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
A contact-mediated transfer mechanism directs in cis localization and spread of Xist RNA www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
The RNA helicase KREH2 directly binds the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
Ciliary neurotrophic factor curbs palmitate-induced inflammatory and metabolic changes in NPY/AgRP hypothalamic neurons www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
Calcium-independent biosensors for multiplexed in vivo imaging of extracellular lactate dynamics www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
Monomeric TDP-43 binds GU-rich RNA via its NTD but only its oligomers block cryptic exon inclusion www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 05/10/2026
Exploring the activation mechanism of the Mic60 subcomplex governing mitochondrial crista junctions www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/10/2026
Rank Normalization Enables Cross Pathway Comparison in Degradation Resolved Proteome Turnover Analysis www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/10/2026
One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/10/2026
Serum IgM crosslinks hepatitis B subviral particles into supramolecular immune complexes www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/10/2026
Simulated microgravity induces aging phenotypes in human organoids www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 01/10/2026
Nucleolar buffering of lamina-associated heterochromatin restrains Progerin-induced ageing programs www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 01/10/2026
Multi-omic profiling reveals impaired luteal resolution and CHK2-regulated inflammation in ovarian aging www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 01/10/2026
Base-mismatched crRNA in CRISPR Enabled Universal One-pot Rapid Nucleic Acid Detection www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
The androgen receptor polyglutamine tract sets the transcriptional balance between muscle growth and atrophy www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
Induction of hysteretic chromatin states by CRISPRa reveals locus-specific encoding of transcriptional memory www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
Adjacent Z-DNA contributes to the formation of homologous DNA triplex www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
THE MICROANATOMY OF INTRACRANIAL HUMAN THROMBI BY SINGLE NUCLEI TRANSCRIPTOMICS www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
The C-terminus of the KREH1 helicase is important for RNA binding and association with mitochondrial RNA editing complexes in T. brucei www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 30/09/2026
Structural basis of nucleosome remodeling by archaeal RNA polymerase during transcription elongation www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Functional specialization of TAF4b governs early prophase I entry and recombination frequency in Brassica rapa www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Thiomorpholino antisense oligonucleotides inhibit telomerase and limit cancer cell proliferation www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Ctcf deficiency in myofibers induces pathological genome reprogramming toward the spontaneous development of myopathy www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Artificial Intelligence-Driven Nanosensing to Identify Circulating Bacterial DNA: A Novel Approach to Breast Cancer Risk Profiling www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Msp1-dependent extraction promotes ubiquitylation of translocation-stalled mitochondrial precursor proteins www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Dietary selenium deficiency drives sex-specific circadian disturbance through redox imbalance and causes early systolic dysfunction in mice www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Dysregulation of FMR1 Splicing in Human Fragile X Syndrome www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/09/2026
Hidden Biodiversity in Wildlife Trade Networks: DNA Barcoding Reveals Fish and Crocodilian Species in Commercialized Swim Bladders www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/09/2026
Fluorosphere-Assisted Nano-Biosensor for Detection of Circulating microRNAs in Non-Small Cell Lung Cancer www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/09/2026
Replication-coupled chromatin assembly cooperates with ATR/CHK1 signaling to suppress DNA damage and premature MMB-dependent mitotic transcription www.biorxiv.org/content/10.64898/20…
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 28/09/2026
Highly inducible transcription is impaired in cells lacking Cyclin T1 (CycT1) of the positive transcription factor b (P-TEFb). www.biorxiv.org/content/10.64898/20…
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