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Matt Lycas

@lycasworks.bsky.social
365 followers 447 following 89 posts

Neuroscientist and Super-Resolution Microscopist

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Reposted by Matt Lycas
Felix Mikus @fmikus.bsky.social · 11/09/2026
Are you interested in the nuclear envelope and are still lacking a dye for it? Try the lectin concanavalin A in #U-ExM! Together with @baukjeje.bsky.social, @gautamdey.bsky.social and @dudinlab.bsky.social and many collaborators sharing species with us we explored the versatility of this dye
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HHMI @hhmi-science.bsky.social · 09/09/2026
An animal’s body is in constant conversation with itself — & HHMI Janelia scientists have built a way to listen in. WHOLISTIC simultaneously records real-time activity from nearly every cell in a living larval zebrafish, a 1st step in understanding more complex bodies like ours: bit.ly/4xMR1Ww.
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Ignacio Vega-Vásquez @igvegvas.bsky.social · 07/08/2026
(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯
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FocalPlane @focalplane.bsky.social · 21/07/2026
🔬🔦In our latest Imaging spotlight, @jclandoni.bsky.social takes us through his recent papers dissecting mitochondria organisation. Juan discusses why they needed to employ multiple imaging approaches to unveil events that had not previously been observed. focalplane.biologists.com/2026/07/21/p...
focalplane.biologists.com
Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - FocalPlane
Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - News
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Damian Dalle Nogare @damiandn.bsky.social · 12/07/2026
FINALLY a histogram in napari! ♥️
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HHMI @hhmi-science.bsky.social · 04/07/2026
Our kind of fireworks: fruit fly neurons stacked in a rapid succession of rainbow colors. This video shows a small sampling of the more than 135,000 neurons in a typical fruit fly's brain, imaged by researchers at our Janelia Research Campus using multicolor flipout technique 🎆
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HHMI @hhmi-science.bsky.social · 28/06/2026
These stunning single-celled organisms can shape-shift & regenerate. Their trumpet-like shape inspired their name: stentor, after the herald in Greek mythology known for his booming voice. 📸: Confocal microscopy by Igor Siwanowicz, HHMI’s Janelia Research Campus
Three stentors
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Science Magazine @science.org · 24/06/2026
The once-obscure Danionella fish takes center stage as a model research organism in a major new project funded by the Howard Hughes Medical Institute. Learn more: scim.ag/3QFj4XM
How AI, $1 billion, and a transparent fish could transform neuroscience
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NPR @npr.org · 16/06/2026
One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human. n.pr/4vV8dYM
n.pr
Is a transparent fish the future of brain science? This center is betting on it
One of the world's leading brain research centers is shifting away from fruit flies and toward a tiny, transparent fish. The goal: to understand how brains control the behavior of an animal or human.
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HHMI @hhmi-science.bsky.social · 15/06/2026
Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior, & building AI-in-the-Loop Discovery — a new way of doing biology. Tiny transparent fish + one of neuroscience’s biggest questions? Let's go: hhmi.news/2BigBets
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Jan Funke @janfunkey.bsky.social · 05/06/2026
And so it begins! Day 1, Lecture 0 of the first DL for Microscopy Image Analysis course at @hhmijanelia.bsky.social. Slides from @florianjug.bsky.social, presented by our TA Federico Carrara. #dljanelia
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Matt Lycas @lycasworks.bsky.social · 05/06/2026
Home microscope project - high NA Phase contrast with the fun Lowa objective Lomo inverted with the Lomo 1.25 NA water inversion phase contrast Need to add light source and camera and phase annulus
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Jakob Troidl @jakobtroidl.bsky.social · 27/05/2026
📢 We're recruiting AI Scientists at HHMI Janelia. I'm biased, but these are exceptional opportunities. You'd join as an independent scientist with access to excellent computational infrastructure, some of the best biological data in the world, and a vibrant collaborative environment.
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Matt Lycas @lycasworks.bsky.social · 27/05/2026
Expansion microscopy rocks
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Journal of Cell Biology @jcb.org · 11/05/2026
Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy. New study from Matthew Domenic Lycas (@lycasworks.bsky.social), Simon Erlendsson et al. @ucph.bsky.social: rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #cryoCLEM
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Matt Lycas @lycasworks.bsky.social · 11/05/2026
Got my pictures back
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Reposted by Matt Lycas
HHMI @hhmi-science.bsky.social · 10/05/2026
This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell. 📸: Andy Moore, HHMI’s Janelia Research Campus
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Matt Lycas @lycasworks.bsky.social · 04/05/2026
My first corresponding author 🔬🎸🦾 rupress.org/jcb/article/... Ever wonder what the ultrastructure of dopaminergic neuron presynaptic sites looks like? Using cryo-CLEM/ET we observed the wild changes that happen at these sites when the neurons fire or are more quiet. In the latest @jcb.org
rupress.org
Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy
Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and
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Rockefeller University Press @rupress.org · 04/05/2026
In @jcb.org, @lycasworks.bsky.social, Erlendsson et al. @ucph.bsky.social develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #Microscopy
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Journal of Cell Biology @jcb.org · 04/05/2026
@lycasworks.bsky.social, Erlendsson et al. @ucph.bsky.social develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. rupress.org/jcb/article/... #Neuroscience #Organelles #StructuralBiology #Microscopy
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Matt Lycas @lycasworks.bsky.social · 27/04/2026
www.protocols.io/view/cryo-ex... New protocol alert!! Cryo-expansion microscopy of C. elegans and Tardigrades using the high pressure freezer!
protocols.io
Cryo-Expansion Microscopy of C. elegans and Tardigrades
Cryo-Expansion Microscopy of C. elegans and Tardigrades. Expansion microscopy (ExM) improves imaging r. Read full protocol, steps, and materials on protocols.io
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Juan C. Landoni @jclandoni.bsky.social · 24/04/2026
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social
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CSHL Courses @cshlcourses.bsky.social · 22/04/2026
Quantitative Imaging: From Acquisition to Analysis (QICM), April 6 - April 21, 2026 Thank you to all of the participants and vendors that supported the course! #cshlcourses #cshl Photo Credit: Max Brambach, Eva de la Serna, and Federico Gasparoli (2026 Teaching Assistants) @qiatcshl.bsky.social
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Matt Lycas @lycasworks.bsky.social · 22/04/2026
So thrilled to be part of Quantitative Imaging @qiatcshl.bsky.social Such an amazing course and now we got a whole new generation of expansion microscopy enthusiasts!
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QI@CSHL @qiatcshl.bsky.social · 21/04/2026
@lycasworks.bsky.social showing expansion microscopy followed by some hands on expansion exercises.
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Juan C. Landoni @jclandoni.bsky.social · 21/04/2026
The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
Landoni lab & UNIL logos, featuring fluorescent images of mitochondria and nematodes
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QI@CSHL @qiatcshl.bsky.social · 20/04/2026
Super Res Sunday! And we are doing all the techniques:)
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QI@CSHL @qiatcshl.bsky.social · 20/04/2026
Hari Shroff giving the QI keynote on structural illumination microscopy, adaptive optics and new biosensors. Wow!
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QI@CSHL @qiatcshl.bsky.social · 19/04/2026
Light sheet lab. We image anything from cells to plants to shrimp. @fedegasparoli.bsky.social @excitedemissions.bsky.social are running the machines!
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QI@CSHL @qiatcshl.bsky.social · 18/04/2026
Light Sheet Saturday is here. @jencwaters.bsky.social and @talley.codes lecture on how to improve your photon budget by illuminating from the side.
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QI@CSHL @qiatcshl.bsky.social · 17/04/2026
AI for image analysis. @florianjug.bsky.social @bethcimini.bsky.social @damiandn.bsky.social are showing off the power of the machines:)
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QI@CSHL @qiatcshl.bsky.social · 18/04/2026
Pizza and image analysis. Because there’s no hackin‘ without snackin‘. @damiandn.bsky.social @bethcimini.bsky.social
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QI@CSHL @qiatcshl.bsky.social · 16/04/2026
Cake and image analysis. True QI bliss:) @damiandn.bsky.social @bethcimini.bsky.social @emiglietta.bsky.social teaching 3D segmentation.
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QI@CSHL @qiatcshl.bsky.social · 15/04/2026
Looking for samples for our lightsheet microscope and expansion microscopy lab, @fedegasparoli.bsky.social and @lycasworks.bsky.social go on an expedition during low tide.
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QI@CSHL @qiatcshl.bsky.social · 14/04/2026
Hands on TIRF microscopy and machine learning segmentation has students up all night.
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QI@CSHL @qiatcshl.bsky.social · 14/04/2026
Hard to decide what’s better the beautiful weather or the lectures by @talley.codes and @jencwaters.bsky.social on confocal microscopy. (it’s obviously the lectures)
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QI@CSHL @qiatcshl.bsky.social · 13/04/2026
We are getting serious about analysis. Today Hunter Elliott and @florianjug.bsky.social introduce machine learning and AI. It’s not magic, it’s computers.
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QI@CSHL @qiatcshl.bsky.social · 12/04/2026
Today’s lectures on live cell imaging and fluorescent proteins by @jencwaters.bsky.social and @talley.codes Every photon counts!
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QI@CSHL @qiatcshl.bsky.social · 11/04/2026
We tried other brands but nothing works quite like a Guinness for our light sheet microscope. Future collab?
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QI@CSHL @qiatcshl.bsky.social · 10/04/2026
Today Hunter Elliott is lecturing on image processing. Key take-home before lunch: There is no free lunch:)
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QI@CSHL @qiatcshl.bsky.social · 08/04/2026
This morning‘s lecture is about Koehler illumination. Pop quiz: What happens when you close the condenser aperture?
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Juan C. Landoni @jclandoni.bsky.social · 05/04/2026
Check out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue! www.science.org/doi/10.1126/...
science.org
Mitochondrial genomes on a string of pearls
Transient membrane constrictions, or “pearling,” underlie the regular spacing of mitochondrial genomes
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Matt Lycas @lycasworks.bsky.social · 03/04/2026
The longstanding mystery for how mitochondria segregate and position their DNA has been solved! Read all about it: www.science.org/doi/10.1126/... @jclandoni.bsky.social Here is Juan and I at the 4th of July parade at MBL physiology
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Juan C. Landoni @jclandoni.bsky.social · 03/04/2026
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
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Mark Bates @wmarkbates.bsky.social · 31/03/2026
Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort. www.biorxiv.org/cgi/content/...
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Matt Lycas @lycasworks.bsky.social · 09/02/2026
All set for some expanding
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Teng-Leong Chew @scopeshifu.bsky.social · 28/01/2026
🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!
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Andrew Kennard @askennard.bsky.social · 20/01/2026
Found the unbroken link: www.biorxiv.org/content/10.6...
biorxiv.org
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Suliana Manley @sulianamanley.bsky.social · 20/01/2026
@lycasworks.bsky.social developed quantitative expansion (qExM) to estimate endogenous protein quantities in situ. His ExM protocols offer epitope preservation and accessibility so that standard Western Blot antibodies can be used. Also, check out the cristae, supercomplexes, specialized mitos 🤩
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