Sign in

Mike Dorrity

@mwdorr.bsky.social
1.2K followers 1.6K following 31 posts

Group Leader at EMBL Heidelberg. temperature, single cell genomics, proteins, and lots of fish.

PostsRepliesMedia
Mike Dorrity @mwdorr.bsky.social · 13/09/2026
🧫 We’re hiring a staff/research scientist to develop new experimental approaches that capture cell state dynamics. Join us in Heidelberg, details + application here: embl.wd103.myworkdayjobs.com/EMBL/job/Hei... Closes September 30th
embl.wd103.myworkdayjobs.com
Laboratory Officer
The Dorrity group at EMBL Heidelberg is seeking a motivated and skilled molecular biologist to join as a Laboratory Officer. Our group uses cutting-edge single-cell genomic techniques to study how cel...
11318
Reposted by Mike Dorrity
Teresa Rayon @trayon.bsky.social · 12/09/2026
‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇
babraham.current-vacancies.com
Postdoctoral Research Scientist - Babraham
The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...
14140
Mike Dorrity @mwdorr.bsky.social · 08/09/2026
We’re honored and excited to host - we have a laundry list of fish evo devo ideas and finally the time and space to dig into them ! Welcome @fishevodevogeno.bsky.social
061
Reposted by Mike Dorrity
Braasch Lab @ Michigan State University @fishevodevogeno.bsky.social · 30/08/2026
Sabbatical with @brainyfishguts.bsky.social starts now! * 4,208 miles to Heidelberg - Hit it! See you soon @mwdorr.bsky.social & @lsaunders.bsky.social!
3211
Reposted by Mike Dorrity
Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
712947
Reposted by Mike Dorrity
Jay Shendure @jshendure.bsky.social · 31/07/2026
Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
313458
Reposted by Mike Dorrity
Arnaud Krebs @arnaudkr.bsky.social · 23/07/2026
One of my favorite meetings. Many slots for abstract selected talks! Friendly to junior scientist - apply!
092
Mike Dorrity @mwdorr.bsky.social · 23/07/2026
We’re accepting abstracts for QBMM, come join an excellent set of speakers, due early Sept
0187
Reposted by Mike Dorrity
James Gagnon @james-gagnon.bsky.social · 15/06/2026
Our new paper on interferon signaling during the response to heart injury is out today. doi.org/10.1242/bio....
doi.org
Interferon signaling is required for early neutrophil recruitment after zebrafish heart injury
Summary: Interferon-Φ1 signaling is required for early neutrophil recruitment after zebrafish heart injury, revealing a key immune trigger that shapes inflammation and may influence efficient cardiac ...
1256
Reposted by Mike Dorrity
Gaurav Vaidya @gvaidya.bsky.social · 01/07/2026
The first preprint from my PhD is out! :thread: How does an animal choose between two completely different reproductive fates? Here’s how one planarian does it :point_down: www.biorxiv.org/content/10.6...
biorxiv.org
Life-cycle trajectory inference links temperature-gated progenitors to reproductive fate
Temperature shapes reproductive strategies across animals, yet how individuals switch between sexual and asexual reproduction remains unknown. We establish the planarian Phagocata morgani as a model f...
13715
Mike Dorrity @mwdorr.bsky.social · 01/07/2026
First preprint stemming from a fantastic collaboration with @hanhtkvu.bsky.social Shared PhD student and BIF fellow @gvaidya.bsky.social led this tour de force - check it out ! How does temperature affect whole-organism cellular trajectories?
1192
Reposted by Mike Dorrity
Syd Sattler @sydsat.bsky.social · 29/06/2026
What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵
biorxiv.org
Early immune cell development precedes gastrulation in annual killifish
During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...
38528
Reposted by Mike Dorrity
Nicoletta Petridou @nicolettapetridou.bsky.social · 23/06/2026
Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234
biorxiv.org
Cellular timing heterogeneity regulates phase transitions in living matter
Rigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...
18630
Reposted by Mike Dorrity
Svetlana Dodonova @dodonova-sveta.bsky.social · 19/06/2026
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
815363
Mike Dorrity @mwdorr.bsky.social · 19/06/2026
First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...
biorxiv.org
Quantitative mapping of heterochrony to species-specific phenotypes
The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...
511946
Reposted by Mike Dorrity
James Gagnon @james-gagnon.bsky.social · 28/05/2026
Excited to share the published version of MIC-Drop-seq @natcomms.nature.com! Shoutout to co-lead authors @claycarey.bsky.social @sparvez.bsky.social for driving this work. Excited to see where this new scale of single-cell perturbation screening goes next. www.nature.com/articles/s41...
2317
Reposted by Mike Dorrity
Champi @jpascualanaya.bsky.social · 16/04/2026
🔈 Heading to Euro Evo-Devo #EED2026 in Glasgow? Don't miss out our Fish Satellite Meeting! Co-organized with Mike Dorrity @mwdorr.bsky.social, Ralf Schneider @ralfschneider.bsky.social, Laure Sanders @lsaunders.bsky.social and Joost Woltering, and with a list of outstanding speakers 👇
32413
Reposted by Mike Dorrity
Arnaud Krebs @arnaudkr.bsky.social · 24/03/2026
Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org
17118
Reposted by Mike Dorrity
Arnaud Krebs @arnaudkr.bsky.social · 20/03/2026
Quantitative biology community: QBMM is back! Line up is just stellar and many abstract selected talks. Apply! 👇
1123
Mike Dorrity @mwdorr.bsky.social · 19/03/2026
The time has come for another round of QBMM - we have a fantastic lineup of speakers in genomics, systems biology, and modeling cell dynamics. Check it out! Co-orgs @elowitzlab.bsky.social @tinekelenstra.bsky.social @trayon.bsky.social @savitski-lab.bsky.social and I look forward to seeing you
0166
Reposted by Mike Dorrity
Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 23/02/2026
Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you! www.ezm2026.org Abstract submission deadline is March 15th.
32716
Reposted by Mike Dorrity
jordivangestel.bsky.social @jordivangestel.bsky.social · 08/11/2025
Please join us for this exciting new conference on the emergence, function and evolution of biological collectives - unpacking the wonderful world of self-organization: www.embl.org/about/info/c...
embl.org
Collectivity in living systems: emergence, function, and evolution
12812
Reposted by Mike Dorrity
Ewan Birney @ewanbirney.bsky.social · 08/09/2025
Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Group Leader – AI in Biology
Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...
23630
Mike Dorrity @mwdorr.bsky.social · 04/09/2025
Very excited to share - the ERC StG is a game-changer for us 🙏 We're going to learn the rules for timing control across cell types in the embryo and we think we can tune them too 🎛️ ⏳📈- reach out if you’d like to be involved !
12574
Mike Dorrity @mwdorr.bsky.social · 13/08/2025
EMBL is an amazing place to start a lab and bring new direction to your research program (ask me how I know) - come join us in Heidelberg !
3107
Reposted by Mike Dorrity
Eileen Furlong @eileen-furlong.bsky.social · 30/07/2025
To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
0193225
Reposted by Mike Dorrity
Typas Lab @typaslab.bsky.social · 30/07/2025
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
embl.wd103.myworkdayjobs.com
Group Leader – Molecular Systems Biology Unit
Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...
17278
Reposted by Mike Dorrity
Camilla Autorino @cami-autorino.bsky.social · 11/06/2025
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️
310935
Reposted by Mike Dorrity
Ewan Birney @ewanbirney.bsky.social · 29/05/2025
We have updated our preprint on GxE and epipstatic interactions in vertebrates, lead authors Bettina Welz and @saulpierotti.bsky.social, a collaboration between my lab, @wittbrodtlab.bsky.social, Felix Loosli and Kiyoshi Naruse's lab. www.biorxiv.org/content/10.1...
biorxiv.org
Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model
Phenotypic variation arises from the interplay between genetic and environmental factors. However, disentangling these interactions for complex traits remains challenging in observational cohorts such...
2102
Reposted by Mike Dorrity
kausthubh.bsky.social @kausthubh.bsky.social · 15/05/2025
I attended the exciting symposium organized by @floravincent.bsky.social @mwdorr.bsky.social, @nicoledubilier.bsky.social, @gautamdey.bsky.social & Susanna Coelho LOTs of takeaways from the Symposium (from biology to climate change) 🚨Here are a few important ones in my listicle below 👇
embl.org
Biology beyond conventional model organisms – a whole new world | EMBL
An EMBL | EMBO symposium explored the ‘wild frontiers’ of model organisms, from phytoplankton to sea anemones, waterstriders, roundworms, and more.
072
Reposted by Mike Dorrity
Neil Shubin @neilshubin.bsky.social · 21/05/2025
New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...
phys.org
Teeth first evolved as sensory tissue in the armored exoskeletons of ancient fish, fossil scans find
Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...
15727279
Mike Dorrity @mwdorr.bsky.social · 26/04/2025
Thanks for all the great discussions - @msarscentre.bsky.social is a one-of-kind research environment ! and very sunny in my limited sampling..
0160
Reposted by Mike Dorrity
Michael Sars Centre @msarscentre.bsky.social · 25/04/2025
How does temperature impact development? 🌡️ Michael Dorrity @mwdorr.bsky.social from @embl.org shared his integrated approach to revealing the relationship between temperature stress and developmental rate in fishes 🐟🐠 Thank you for a great talk and discussions! 👏
A man faces an audience in a seminar room, speaking. On a screen behind him, a slide with an image of a fish embryo, and the caption "you could just record developing embryos..."
0186
Reposted by Mike Dorrity
Seungsoo Kim @seungsookim.bsky.social · 25/04/2025
I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594
recruit.ap.uci.edu
Junior / Assistant Specialist: Kim Lab, Developmental & Cell Biology
University of California, Irvine is hiring. Apply now!
12927
Reposted by Mike Dorrity
Brady Lab @bradylabs.bsky.social · 19/04/2025
We have a postdoc position that just opened up in the Brady lab on reprogramming tomato root system architecture in response to changes in nutrient availability - please consider applying! recruit.ucdavis.edu/JPF07095
recruit.ucdavis.edu
Postdoctoral Researcher- Brady Lab
University of California, Davis is hiring. Apply now!
196107
Reposted by Mike Dorrity
Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · 29/03/2025
EMBOMtg Paris May 6-9 @aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social meetings.embo.org/event/25-dev...
meetings.embo.org
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
04019
Reposted by Mike Dorrity
Jamie Hackett @jamiehackett.bsky.social · 11/02/2025
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at @embl.org We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiology👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com
Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
37851
Reposted by Mike Dorrity
Flora Vincent @floravincent.bsky.social · 16/01/2025
Still time to submit an Abstract for the @embl.org symposium on the Wild Frontiers of Model Systems ! If you’re into unconventional, non model systems, bringing more ecology in our understanding of biological processes, Lab-field interface this is for you. www.embl.org/about/info/c... #protistsonsky
embl.org
Wild frontiers of model organisms
02420
Reposted by Mike Dorrity
Tobias Jores @tobiasjores.bsky.social · 08/01/2025
📢Job alert! #joboffer #plantscijobs Are you interested in plant gene regulation and synthetic biology? I have two open #postdoc positions in my #EmmyNoether group @hhu.bsky.social. See below for more information (or visit www.synthetic-biology.hhu.de/available-po...). Please share!
artwork by Sayeh Gorjifard (@lampoona.bsky.social)
21616
Reposted by Mike Dorrity
Lionel Christiaen, PhD (he/him/his) @lionlchristiaen.bsky.social · 23/12/2024
Xmas teaser: Mike Dorrity @mwdorr.bsky.social and I are looking for a joint postdoc to study "The Hallmarks of Thermal Adaptation" in Aquatic Chordates as part of the EIPOD-LinC program www.embl.org/about/info/p... and the partnership between @embl.org and @msarscentre.bsky.social.
embl.org
EIPOD-LinC Fellowship Programme – Postdoctoral Programme
1148
Mike Dorrity @mwdorr.bsky.social · 19/12/2024
Fish friends and beyond - I’m co-organizing a conference and it’d be great to see you there. Check it out!
086
Mike Dorrity @mwdorr.bsky.social · 10/12/2024
Behind in posting, but thinking back to sunnier months…we had a great scientific retreat on theory in biology, trajectories, timing and environmentally-sensitive growth with our friends in the Vu lab and S. Werner. Thanks to Soham for the excellent photo!
020
Reposted by Mike Dorrity
Flora Vincent @floravincent.bsky.social · 04/12/2024
Join us for a brand new EMBO/EML Symposium on 'Wild frontiers of model organisms' in April 2025 ❗ Bottom line: - great line up of speakers: M. McFall-Ngai, Jb Raina, M. Prakash, E Santos etc... - to explore old models but in new context or ways of building new model systems s.embl.org/ees25-02 1/n
s.embl.org
Wild frontiers of model organisms
13425
Reposted by Mike Dorrity
Jeff Farrell @jeffreyafarrell.bsky.social · 26/11/2024
Out now in Dev Cell! scRNAseq trajectories describe the cascade of gene expression as cells differentiate, but turning them into a clear understanding of the underlying biology of a cell type's development remains challenging. authors.elsevier.com/c/1k9qj5Sx5g... (1/)
Graphical abstract of the study
1416050
Mike Dorrity @mwdorr.bsky.social · 23/12/2023
My lab is looking for a postdoc shared with @OliverStegle (incoming). Join us to design ambitious multi-sample single-cell experiments in developing embryos, model temporal response patterns, test predictions. Open to different backgrounds and expertise. If you’re interested, get in touch soon!
011
Mike Dorrity @mwdorr.bsky.social · 28/11/2023
Very thankful to the anonymous reviewers, whose input added new dimensions to our study: - new sci-rna-seq experiments for 🥶 and atf6 mutants - upr mutant fails to accelerate development at high temperature 🤯 - explicit DE testing of temperature (not stage) responsive genes
urldefense.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
191