iiinova — where your digital self keeps evolving

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Academy of Medical Sciences @acmedsci.bsky.social · 29/09/2026

Applications are open for our new fellowship programme with @lifearc.bsky.social 🚀 The scheme supports clinician scientists to build the skills, networks and experience needed to turn innovations in rare diseases into real-world impact. See eligibility and apply: bit.ly/4z1bUNQ

Professor Sir Andrew Morris, President of the Academy of Medical Sciences, next to a quote that reads: "With LifeArc, this fellowship gives clinician scientists in rare disease research the funding, mentoring and connections to put their research to use for the patients who are still waiting for it."

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Jez Carlton @jezcarlton.bsky.social · 28/09/2026

Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!

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Simon Cleary @simoncleary.bsky.social · 25/09/2026

There is a clear distinction between processing images to remove noise + spillover to better see real things (fine) and generating fake structures and time points (not fair!)

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Simon Cleary @simoncleary.bsky.social · 25/09/2026

Update on the Nikon Small World in Motion competition - Nikon now calling the AI-generated winning movie a 'rendition' and investigating:

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Valentin Dunsing-Eichenauer @dunsingvalentin.bsky.social · 25/09/2026

#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.

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Robin Bisson @robinbisson.bsky.social · 25/09/2026

Update on the "AI-based triage" which is getting lots of (negative) attention

In recent days, there have also been several reports on social media of applicants seemingly being rejected after “AI-based triage”. The funding, while originating from UKRI, was devolved to the Crane network, which is funded by the Engineering and Physical Sciences Research Council to strengthen the UK’s cybersecurity research ecosystem.

UKRI confirmed it did not carry out the AI triage process. A spokesperson said: “UKRI policy does not allow the use of generative AI to conduct application assessment. We are following up with the Crane network to review this situation in detail and ensure compliance with our assessment conditions.”

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Simon Cleary @simoncleary.bsky.social · 25/09/2026

I would prefer a lottery system to a potentially biased AI-triage. Would also have lower costs for the funder.

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Simon Cleary @simoncleary.bsky.social · 24/09/2026

Even if it were ok to add AI-generated details in the lower half of the movie, what we are now told is a section of one ciliated cell is way too wide to be based on real images of one cell.

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Daniel Fisch @danielhfisch.bsky.social · 23/09/2026

Out now @nature.com! We report a new means of cell communication: receptor-free signal transduction. TLRs engage MyD88 for minutes, yet myddosomes signal for hours. TRAM releases myddosomes from TLRs, letting them mature and sustain signaling in the cytosol. rdcu.be/jGdKxErXyAsa Details below:

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Simon Cleary @simoncleary.bsky.social · 22/09/2026

Nikon seem to have admitted awarding an AI-generated video 1st place in the Small World in Motion contest, which has a rule forbidding AI-generated entries:

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Simon Cleary @simoncleary.bsky.social · 22/09/2026

Some upset regarding the Nikon Small World in Motion winner this year so wanted to highlight that the beautiful image that won the Small World competition in 2022 was the initial inspiration for our project:

Embryonic hand of a Madagascar giant day gecko (Phelsuma grandis) stained for collagen and beta tubulin, from Grigorii Timin and Michel Milinkovitch https://doi.org/10.1016/j.isci.2023.106452

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Simon Cleary @simoncleary.bsky.social · 21/09/2026

First preprint from the lab! We found that fluorescence imaging of fibrillar collagen with fast green FCF is useful for imaging pulmonary fibrosis: doi.org/10.64898/202...

Two images showing fast green FCF staining of fibrillar collagen in magenta. An image of a fibrotic sample on the right shows higher intensity and prevalence of staining compared to a healthy control sample on the left.

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Waggoner Lab @labwaggoner.bsky.social · 05/08/2026

Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections @natcomms.nature.com @kingscollegelondon.bsky.social www.nature.com/articles/s41...

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Richard Sever @richardsever.bsky.social · 27/08/2026

$3.7 billion spent on APCs in 2025. That's ~1000X more than it costs to run bioRxiv/medRxiv. Worth thinking about as we consider how to fund infrastructure... arxiv.org/pdf/2608.16322

arxiv.org

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Caetano Reis e Sousa @reisesousalab.bsky.social · 19/08/2026

Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P

rdcu.be

Why adaptive immunity?

Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

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Simon Cleary @simoncleary.bsky.social · 05/08/2026

The AJP-Lung editorial fellowship is inviting applications for a new round: ow.ly/rUAN50Zq10K I really enjoyed and benefitted from participating - more info in this article from previous fellows: doi.org/10.1152/ajplung.00251.2026

Flyer promoting the AJP-Lung Editorial Fellowship Program with QR code linking to information on applications: ow.ly/rUAN50Zq10K

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Jonathan Kagan @jkagan1.bsky.social · 14/07/2026

A query for the immunologists: Are there any PAMPs left to discover?

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Christophe 🔬 Leterrier @christlet.bsky.social · 08/07/2026

Are tapes a good option for long-term cold storage of microscopy data? I'm looking at storing ~200 TB with no recurring fee (no cloud) and with as little esoteric server/command line fuss as possible www.ibm.com/fr-fr/produc...

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Andy Conway Morris @andymoz78.bsky.social · 23/06/2026

Great to see our new paper out in Nature Communications. In it we describe three novel phenotypes in lungs of patients with pneumonia. Pn1 -a non-neutrophil driven lung injury phenotype, Pn2-a balanced immune response with best recovery and Pn3-persistent inflammation driven by immature neutrophils

rdcu.be

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes

Nature Communications - Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse...

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Simon Cleary @simoncleary.bsky.social · 22/06/2026

Read about how research into lymphatic function is changing our understanding of immune regulation in the lungs in our review: doi.org/10.1016/j.co... Congratulations to co-authors Amy Rivers and Camila Migues Ramirez!

Immunofluorescence staining for lymphatic endothelial cells (green) and smooth muscle (white) in a mouse lung. Image credit: Yurim Seo

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James Manton @jamesdmanton.bsky.social · 02/06/2026

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

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Matthew Freeman @mjafreeman.bsky.social · 27/05/2026

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

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Simon Cleary @simoncleary.bsky.social · 18/05/2026

Sad to hear of the loss of Richard Lehman. Grateful to him and @raj-mehta.bsky.social for recording this podcast - an excellent teaching resource: creators.spotify.com/pod/profile/...

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Hans schoofs @hansschoofs.bsky.social · 18/05/2026

Happy to share that our latest work on VEGFR2 in lymphatic endothelium is published @natcomms.nature.com “VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis” tinyurl.com/47bns9pp This project has been a long journey for the lab @taijamakinenlab.bsky.social , A thread.

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Régis Joulia @regisjoulia.bsky.social · 15/05/2026

🔬 PhD position at Imperial College London! Uncover how pericytes, mysterious vascular cells, drive asthma inflammation. Use spatial transcriptomics, 3D imaging & transgenic models to unlock new therapies. 3-year funded PhD | Oct 2026 start 👉 www.findaphd.com/phds/project... 📧r.joulia@imperial.ac.uk

findaphd.com

Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London on FindAPhD.com

PhD Project - Defining the Immune Functions of Lung Pericytes and Their Dysregulation in Asthma at Imperial College London, listed on FindAPhD.com

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Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 15/05/2026

Happy #FluorescenceFriday. I feel so lucky to get to work with these weird and curious primary macrophages from 🐸. They exhibit myriad different morphologies and behaviours, including spinning endlessly and stationary, kinda like progenitor cells under compression from 🐟. Also actomyosin is strong!

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Peter Hill @peterwshill.bsky.social · 08/05/2026

Thrilled to share the first paper from the lab, out now in Molecular Cell! A wonderful collaboration with @thurstonlab.bsky.social bridging Salmonella host-pathogen interactions and regulatory genomics - two of my favourite things in one story. www.cell.com/molecular-ce... 🦠 🧵1/10

cell.com

Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

Diaz-del-Olmo et al. reveal how a Salmonella virulence protein alters the transcriptional layout of infected macrophages through hyperactivation of a transcription factor and coordinated chromatin rem...

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BioImagingUK @bioimaginguk.bsky.social · 02/04/2026

Thank you to all the fantastic students, supervisors, co-organisers and advisors who took part in this (very) oversubscribed Summer Studentship scheme. Delighted that it has opened doors for the students involved!

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KaminskiMed @kaminskimed.bsky.social · 14/03/2026

After a negative decade - finally a good year for IPF patients - Inhaled Treprostinil associated with a smaller decline in FVC & fewer clinical-worsening events (but also ~30%). Still no improvement - but let’s all hope momentum continues #CurePF4ALL www.nejm.org/doi/full/10....

nejm.org

Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis | NEJM

Preclinical data indicate that inhaled treprostinil may be useful for the treatment of idiopathic pulmonary fibrosis (IPF) through an antifibrotic mechanism, a premise that is supported by clinical...

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Johan Duchêne @johanduchene.bsky.social · 09/03/2026

Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model disrupts bone marrow & masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function tinyurl.com/MImodels

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Rizzuto lab @pregnancyimmunolab.bsky.social · 05/03/2026

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

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Darren Dahly @statsepi.bsky.social · 06/03/2026

Ok pals. Looking to move all my teaching materials open and online, and am developing new modules that I want to start off this way. Content = reading, quizzes, videos, and code tutorials. Opinions on the best platform? Good examples of best practice I can steal from? Many thanks.

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Simon Cleary @simoncleary.bsky.social · 05/03/2026

Few but mighty - check out this cool study implicating gamma delta T cells in controlling macrophage responses in lung cancer!

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Casanova Lab @casanovalab.bsky.social · 02/03/2026

1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...

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Journal of Experimental Medicine @jem.org · 02/03/2026

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

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Li-Kun Phng @phnglab.bsky.social · 26/02/2026

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...

bdr.riken.jp

When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations

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Shruti Naik @drshrutinaik.bsky.social · 26/02/2026

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

nature.com

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

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Martin Valdearcos @mvaldearcos.bsky.social · 20/02/2026

www.biorxiv.org/content/10.6... Excited to share our new preprint: Not all microglia are the same. In this study, we identify a specialized ApoE-dependent program in the median eminence positioning microglial lipid metabolism as a driver of hypothalamic adaptation to nutritional stress.

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Mohamed ElTanbouly @plasmacellguy.bsky.social · 17/02/2026

I am looking for an Illustrator to help with making schematics and diagrams. Might anyone guide me on who to contact? Thanks #science #Illustration #Academia

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Simon Cleary @simoncleary.bsky.social · 16/02/2026

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

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Joachim Goedhart @joachimgoedhart.bsky.social · 07/02/2026

Anyone ever tried super glue (cyanoacrylate) for mounting coverslips with stained mammalian cells, to be used for fluorescence microscopy? I'm looking for ways to conserve microscopy samples for a looooooong time...

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Jonathan Kagan @jkagan1.bsky.social · 06/02/2026

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

nature.com

On the balance of knowledge - Nature Reviews Immunology

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

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Simon Cleary @simoncleary.bsky.social · 27/01/2026

Useful article addressing an often-overlooked way in which research impacts the environment:

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Simon Cleary @simoncleary.bsky.social · 15/01/2026

Nice evidence for a role for the ectonucleotidase CD39 in limiting pulmonary thromboembolism in sickle cell disease with striking footage of this process!

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Adam Kucharski @adamjkucharski.bsky.social · 14/01/2026

"Does this handle survival plots too?" asked @load-dependent.bsky.social Yes it does! See below for RECOVERY. Only catch is it doesn't like the dotted lines that appear in some survival plots (because the PDF geometry treats this as lots of little separate lines rather than one single entry).

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