Noninvasive neuroprosthesis breakthrough: Brain2Qwerty decodes sentences from brainwaves in 35 volunteers. High potential with no surgery needed! #Neurotech PMID:42374156, Nat Neurosci 2026, @NatureNeuro doi.org/10.1038/s41593-026-02303-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
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Noninvasive decoding of typed sentences from human brain activity | Nature Neuroscience
Modern neuroprostheses can now restore communication in patients who have lost the ability to speak or move. However, implanting these invasive devices comes with risks inherent to neurosurgery. Here we introduce a noninvasive method to decode the production of sentences from brain activity and demonstrate its efficacy in a cohort of 35 healthy volunteers. For this, we present Brain2Qwerty, a new deep learning architecture trained to decode sentences from either electro- or magnetoencephalography, while participants typed briefly memorized sentences on a QWERTY keyboard. With magnetoencephalography, Brain2Qwerty reaches, on average, a character error rate of 29% and substantially outperforms electroencephalography (character error rate: 65%). For the best participants, the model achieves a character error rate of 18%, and can perfectly decode a variety of sentences outside of the training set. Overall, these results narrow the gap between invasive and noninvasive methods and thus open
