Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.

The following will be offered in this call:Up to 8 FPI positions associated with the “Proyectos de Generación de Conocimiento 2025” Call (funded by the Agencia Estatal de Investigación AEI- MICINN).Ch...

"To remain global leaders, a competitive economic power, and a sovereign actor, Europe needs strong science and innovation." Seven scientific organizations, representing...

Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...

Centriole biogenesis is regarded as template-free, variation-free, and genetically determined. Here, the authors describe an adaptable process where inheritance and selection both opera...

During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...

Centrosomes are critical microtubule organizing centers comprising centrioles surrounded by PeriCentriolar Material (PCM). Centrioles also template the axoneme of cilia and flagella. As a result of t…

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...

The European Research Council (ERC) is set to launch its first seven-year €7 million super grant call in May next year.The grants, called ERC+, will be open to researchers at all career stages and in ...

While subcellular structures like centrioles assemble flawlessly from protein components, it is unknown whether instructions from outside the components are involved. Centrioles build on the cartwheel...

CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.

Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...

Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.