Journal of Cell Biology (JCB) publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmen...

Welcome to the Department of Systems Biology at UC Irvine Leading the way to Discovery, Explanation, and Prediction Department of […]

Ning Xu - Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia (PCD), a genetic disorder affecting respiratory function.

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

Hong et al. identify Jhc1, a ciliary protein localizing at the EDT of MCC cilia, conserved only among non-mammalian vertebrates. They provide insights into how evolution shapes the diversity of the ti...

Here, they identify a binding site on the Sonic Hedgehog signaling protein Smoothened for the allosteric regulator arachidonic acid (AA). A mutation that disrupts AA binding to this pocket compromises...

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Mu He is an Assistant Professor at The University of Hong Kong. She received her undergraduate degree from Cornell University in the USA and went on to pursue a PhD with Kathryn Andreson at the Memori...

HHMI's 2027 Gilliam Fellowship guide is out. What changed: an earlier October 27 deadline, expanded eligibility, a higher stipend, and a new postdoc pathway.

Summary: This Review explains how recent advances have expanded our models of how, when and where primary cilia disassemble and discusses emerging roles of altered disassembly in disease.

Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...

Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...

Children’s Medical Center Research Institute at UT Southwestern (CRI) is a joint venture of UT Southwestern Medical Center and Children’s ...

Hedgehog signaling in vertebrates is transduced by the transmembrane protein Smoothened (SMO) on the primary cilium, but the underlying mechanisms remain unclear. This study shows that SMO and ciliary...

In situ proteomics and expansion microscopy reveal nanoscale organization of postsynaptic proteins on neuronal cilia.

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Receptor-type E3 ubiquitin ligases enable extracellular signals to control ubiquitylation in the cytoplasm, playing widespread roles in development, m…

TBC1D19 and KIAA1841 are subunits of the tubulin poly-glutamylase complex and essential for assembly of an active holo-enzyme. TBC1D19 also promotes assembly/stability of primary cilia and phosphoinos...