iiinova — where your digital self keeps evolving

Genes & Development @genesdev.bsky.social · 4h

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Dangerous liaisons: interactions between cancer cells and adipocytes as drivers of cancer progression By Carolina Dehesa Caballero and Almut Schulze ➡️ ow.ly/lFIS50ZRaTF #cancer #adipocytes #metabolism

010

Genes & Development @genesdev.bsky.social · 7h

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Nuclear type I myosins actively support nucleolar and nuclear structure and function By Peng et al. and Brian Freeman ➡️ ow.ly/UNrp50ZRaHs #genome #nucleus #myosin

000

Genes & Development @genesdev.bsky.social · 29/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities By Jayachandran et al. and Petr Cejka ➡️ ow.ly/IFke50ZRacV Petr Cejka Institute for Research in Biomedicine Università della Svizzera italiana #DNA #DNArepair

002

Genes & Development @genesdev.bsky.social · 28/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Honeybadger, a PVT1-derived micropeptide, is a critical negative regulator of RAS–MAPK signaling in MYC-driven tumors By Paithane et al. and Anindya Bagchi ➡️ ow.ly/9HXs50ZR96x Also read about Firefox: ➡️ ow.ly/LsW750ZR96p

011

Genes & Development @genesdev.bsky.social · 28/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Firefox, a protein encoded by circular PVT1, is essential for MYC-driven oncogenesis By Tiwari et al. and Anindya Bagchi ➡️ ow.ly/yESB50ZR92i Also read about Honeybadger: ➡️ ow.ly/WsCF50ZR92k #cancer #MYC #KRAS #lncRNA

001

Genes & Development @genesdev.bsky.social · 25/09/2026

🎙️ G&D Voices: Author Oliver Hobert 🎙️ What sets G&D apart? Here is what G&D author, Oliver Hobert had to say! Learn more here: ➡️ genesdev.cshlp.org

032

Genes & Development @genesdev.bsky.social · 25/09/2026

🆕 ADVANCE ONLINE 🆕 CANCER METABOLISM REVIEW: Lysosomal metabolism in pancreatic cancer and its crosstalk with host physiology By Cheng et al. and Costas Lyssiotis ➡️ ow.ly/ByRW50ZRatT Caleb Cheng Lyssiotis Lab #pancreaticcancer #metabolism #lysosome

011

Genes & Development @genesdev.bsky.social · 24/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Temporal gating dictates stress-induced transcript export from the nucleus By Helton et al. and Stephanie Moon ➡️ ow.ly/Q5mn50ZR8fg Stephanie Moon #mRNA #stress #RNAexport

042

Genes & Development @genesdev.bsky.social · 23/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs By Dix et al. and Matthias Soller ➡️ ow.ly/jspT50ZPTe1 Matthias Soller David McQuarrie The University of Manchester #Drosophila

032

Genes & Development @genesdev.bsky.social · 22/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Differential control of both cell cycle-regulated and quantitative histone mRNA expression by Drosophila Mute By Geisler et al. and Robert Duronio ➡️ ow.ly/WVfT50ZPT2y Mark Geisler #histone #replication #mRNA #Drosophila

061

Genes & Development @genesdev.bsky.social · 21/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates By Shimada et al. and Kei-ichiro Ishiguro ➡️ ow.ly/zmPg50ZPSkH Ishiguro Lab #celldivision #transcription #vertebratedevelopment

015

Genes & Development @genesdev.bsky.social · 18/09/2026

We are saddened by the loss of G&D's long-time Editor, Terri Grodzicker. When Terri stepped down as Editor in 2022, friends and colleagues wrote about her contributions to the research community. We are re-visiting these pieces, and thinking of her. ➡️ genesdev.cshlp.org/content/37/1-2.t…

066

Genes & Development @genesdev.bsky.social · 17/09/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture By Mendoza-Figueroa et al. and Kathy Fange Liu ➡️ ow.ly/ty5R50ZOM7h @kathyliulab.bsky.social University of Pennsylvania Penn Medicine #RNA #nucleus #genome

053

Genes & Development @genesdev.bsky.social · 16/09/2026

RESEARCH PAPER: A conserved Notch–Meis1–Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells By Sur, Segal et al., and Jeffrey Farrell ➡️ genesdev.cshlp.org/content/40/17-18… Jeff Farrell Abhinav Sur #intestine #pHsensing #Notch

031

Genes & Development @genesdev.bsky.social · 15/09/2026

RESEARCH PAPER: Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity By Dutta et al., Gilberto Garcia and Ryo Higuchi-Sanabria ➡️ genesdev.cshlp.org/content/40/17-18… @usc.edu @uscleonarddavis.bsky.social

031

Genes & Development @genesdev.bsky.social · 15/09/2026

OUTLOOK: An antisense antidote to oncogenic poison exons By René Arvola and Guramrit Singh ➡️ genesdev.cshlp.org/content/40/17-18… Also read: ➡️ genesdev.cshlp.org/content/40/17-18… Guramrit Singh #RNA #splicing #cancer

000

Genes & Development @genesdev.bsky.social · 14/09/2026

RESEARCH PAPER: Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction By Islam et al. and Mohammad Alinoor Rahman ➡️ genesdev.cshlp.org/content/40/17-18… #RNA #splicing #cancer

000

Genes & Development @genesdev.bsky.social · 14/09/2026

ON THE COVER: Using CRASP-seq to uncover key regulators of UPR. Artwork by Kate Zvorykina (Ella Maru Studio) Learn more in this study by Kim et al., and Thomas Gonatopoulos-Pournatzis: ➡️ genesdev.cshlp.org/content/40/17-18…

010

Genes & Development @genesdev.bsky.social · 11/09/2026

PERSPECTIVE: Pediatric sarcomas: challenges and opportunities By Gao et al., and Lillian Guenther ➡️ genesdev.cshlp.org/content/40/17-18… #pediatriccancer #pediatricsarcoma #cancertherapeutics

000

Genes & Development @genesdev.bsky.social · 11/09/2026

Read the G&D Perspective: ➡️ genesdev.cshlp.org/content/40/1...

046

Genes & Development @genesdev.bsky.social · 10/09/2026

RESEARCH PAPER: Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance By Chen et al., and Carolyn Phillips ➡️ genesdev.cshlp.org/content/40/17-18… Carolyn Phillips Shihui Chen The University of Southern California

010

Genes & Development @genesdev.bsky.social · 09/09/2026

RESEARCH PAPER: MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice By Lukaszewicz et al., Scott Keeney, and Maria Jasin ➡️ genesdev.cshlp.org/content/40/17-18… Memorial Sloan Kettering Cancer Center University of Michigan #DNArepair #mutagenesis #genome

000

Genes & Development @genesdev.bsky.social · 08/09/2026

RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1 By Kim et al., and Thomas Gonatopoulos-Pournatzis ➡️ genesdev.cshlp.org/content/40/17-18… #RNA #splicing #stress #UPR

022

Genes & Development @genesdev.bsky.social · 07/09/2026

RESEARCH PAPER: Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes By Gomez-Gil et al., and Snezhana Oliferenko ➡️ genesdev.cshlp.org/content/40/17-18… Snezhka Oliferenko The Francis Crick Institute King's Faculty of Life Sciences & Medicine

032

Genes & Development @genesdev.bsky.social · 04/09/2026

REVIEW: Maternal small RNAs as gatekeepers of hybrid compatibility in plants and animals By Katarzyna Dziasek and Claudia Köhler ➡️ genesdev.cshlp.org/content/40/17-18… Claudia Köhler Max Planck Institute of Molecular Plant Physiology 🌱🧪

010

Genes & Development @genesdev.bsky.social · 03/09/2026

RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation By López-Palacios et al., and Joshua L. Andersen ➡️ genesdev.cshlp.org/content/40/17-18… Huntsman Cancer Institute #STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR

000

Genes & Development @genesdev.bsky.social · 02/09/2026

RESEARCH PAPER: Machine learning analysis of the human initiator region reveals key features of different types of core promoters By Rhyne-Carrigg et al., and James T. Kadonaga ➡️ genesdev.cshlp.org/content/40/17-18… UC San Diego #transcription #machinelearning

030

Genes & Development @genesdev.bsky.social · 01/09/2026

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles online now at Genes & Development! Also in this issue, a Perspective on the state of pediatric sarcoma research, a Review on RNAs in hybrid compatibility, and more... Click here to learn more: ➡️ genesdev.cshlp.org/content/40/17-18…

000

Genes & Development @genesdev.bsky.social · 31/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: A conserved Notch–Meis1–Pbx cascade specifies secretory progenitors into spatially diverse intestinal best4+ cells By Sur, Segal et al., and Jeffrey Farrell ➡️ ow.ly/mMhL50ZFnYi Jeff Farrell Abhinav Sur #intestine #pHsensing #Notch #cellspecification

020

Genes & Development @genesdev.bsky.social · 28/08/2026

🌟 G&D SPOTLIGHT 🌟 G&D is pleased to present a collection of recent articles that offer new insights into the processes shaping gene expression and cell function. Learn more about chromatin regulation, RNA processing, and more here: ➡️ genesdev.cshlp.org/site/misc/molreg…

010

Genes & Development @genesdev.bsky.social · 28/08/2026

🆕 ADVANCE ONLINE 🆕 REVIEW: Maternal small RNAs as gatekeepers of hybrid compatibility in plants and animals By Katarzyna Dziasek and Claudia Köhler ➡️ ow.ly/Gtmx50ZFm9m Claudia Köhler Max Planck Institute of Molecular Plant Physiology 🌱🧪 #smallRNA #inheritance #hybridization #evolution

022

Genes & Development @genesdev.bsky.social · 27/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity By Dutta et al., Gilberto Garcia and Ryo Higuchi-Sanabria ➡️ ow.ly/vqZF50ZFlAO @usc.edu @uscleonarddavis.bsky.social

010

Genes & Development @genesdev.bsky.social · 27/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes By Gomez-Gil et al., and Snezhana Oliferenko ➡️ ow.ly/VfIS50ZFkK4 Snezhka Oliferenko The Francis Crick Institute King's Faculty of Life Sciences & Medicine

011

Genes & Development @genesdev.bsky.social · 26/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: RBM39 modulates UPR signaling through alternative splicing of IRE1α/ERN1 By Kim et al., and Thomas Gonatopoulos-Pournatzis ➡️ ow.ly/B7BF50ZFl79 #RNA #splicing #stress #UPR

031

Genes & Development @genesdev.bsky.social · 26/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation By López-Palacios et al., and Joshua L. Andersen ➡️ ow.ly/ljPI50ZFk2g Huntsman Cancer Institute #STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR

000

Genes & Development @genesdev.bsky.social · 25/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction By Islam et al. and Mohammad Alinoor Rahman ➡️ ow.ly/ukZ650ZFjFr #RNA #splicing #cancer

000

Genes & Development @genesdev.bsky.social · 24/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance By Chen et al., and Carolyn Phillips ➡️ ow.ly/uR7Y50ZztGS Carolyn Phillips Shihui Chen The University of Southern California #granules #RNA #RNAi

021

Genes & Development @genesdev.bsky.social · 21/08/2026

🆕 ADVANCE ONLINE 🆕 PERSPECTIVE: Pediatric sarcomas: challenges and opportunities By Gao et al., and Lillian Guenther ➡️ ow.ly/VG3Z50Zzsbs #pediatriccancer #pediatricsarcoma #cancertherapeutics

010

Genes & Development @genesdev.bsky.social · 20/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice By Lukaszewicz et al., Scott Keeney, and Maria Jasin ➡️ ow.ly/gi7b50Zzrye Memorial Sloan Kettering Cancer Center University of Michigan #DNArepair #mutagenesis #genome #evolution

012

Genes & Development @genesdev.bsky.social · 19/08/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Machine learning analysis of the human initiator region reveals key features of different types of core promoters By Rhyne-Carrigg et al., and James Kadonaga ➡️ ow.ly/csE350ZzqTh UC San Diego #transcription #machinelearning

021

Genes & Development @genesdev.bsky.social · 18/08/2026

RESEARCH PAPER: PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila By Atkinson et al., and Thomas Jenuwein ➡️ genesdev.cshlp.org/content/40/15-16… Derek Atkinson @mpi-ie.bsky.social

000

Genes & Development @genesdev.bsky.social · 17/08/2026

RESEARCH PAPER: The basic helix–loop–helix transcription factor TCF4 recruits the Mediator complex to activate gonadal genes and drive ovarian development By O'Neil et al., and Blanche Capel ➡️ genesdev.cshlp.org/content/40/15-16… Duke University @dukecellbiology.bsky.social

011

Genes & Development @genesdev.bsky.social · 17/08/2026

ON THE COVER: Transcription factor TCF4 primes gonad specification. Image captured by Eleanore O'Neil. Learn more in this study by O'Neil et al., and Blanche Capel: ➡️ genesdev.cshlp.org/content/40/15-16… Duke University @dukecellbiology.bsky.social

072

Genes & Development @genesdev.bsky.social · 14/08/2026

OUTLOOK: Isoform–paralog specificity and tissue-dependent vulnerabilities in neurological disorders By Karina Hernandez-Quijada and Kenneth Kwan ➡️ genesdev.cshlp.org/content/40/15-16… Also read: ➡️ genesdev.cshlp.org/content/40/15-16… University of Michigan

010

Genes & Development @genesdev.bsky.social · 13/08/2026

RESEARCH COMMUNICATION: TET1 noncatalytic activity shapes the chromatin landscape associated with de novo methylation establishment in the male germline By Prasasya et al., and Marisa Bartolomei ➡️ genesdev.cshlp.org/content/40/15-16… University of Pennsylvania Penn Medicine

073

Reposted by Genes & Development

Eric Chevet @ericchevet.bsky.social · 09/08/2026

Good evening! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: @genesdev.bsky.social RBM39 modulates UPR signaling through alternative splicing of IRE1α/ ERN1 genesdev.cshlp.org/content/earl...

biomed.news

bims-proteo 2026-08-09 papers

053

Genes & Development @genesdev.bsky.social · 12/08/2026

RESEARCH PAPER: SMARCAL1 is a candidate therapeutic target for ALT-positive tumors By Taglialatela et al., and Alberto Ciccia ➡️ genesdev.cshlp.org/content/40/15-16… Alberto Ciccia Angelo Taglialatela Columbia University #cancer #telomere #cancertherapy

021

Genes & Development @genesdev.bsky.social · 11/08/2026

RESEARCH PAPER: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2 By Begg, Tracey et al., and Kristen Lynch ➡️ genesdev.cshlp.org/content/40/15-16… University of Pennsylvania Penn Medicine #kinase #nuclearspeckle #RNA #RNAsplicing

041

Genes & Development @genesdev.bsky.social · 10/08/2026

📽️ G&D Tapes 📽️ G&D Author, Aleksandra Anisimova, describes how RNA binding protein IGF2BP3 regulates effector mRNAs of the Unfolded Protein Response during ER stress. In this issue of #genesdev: ➡️ genesdev.cshlp.org/content/40/15-16… Elif Karagöz Max Perutz Labs Vienna

041