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Nature Communications - This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces...

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

The emergence of eukaryotes from a merger between an archaeon and a bacterial cell ∼two billion years ago involved a profound change in cellular organisation. While the order in which different featur...

Nature Communications - This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces...

Microfluidics involves the manipulation of flows at the microscale, typically requiring external power sources to generate pressure gradients. Alte...

Data and codes corresponding to the preprint:

Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...

Research Assistant or Master Thesis worker, group Hakala

Doctoral Researcher, group Hakala

VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...

YouTube video by Roux Lab - University of Geneva

The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...