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Tim Rhoads

@timwrhoads.bsky.social
1.7K followers 1.4K following 190 posts

Assistant Professor. Interested in metabolism, RNA, and aging. All opinions my own (and not my employers).

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Reposted by Tim Rhoads
William Garland @willgarland.bsky.social · 29/09/2026
New from the lab! We uncover how the cap-binding complex promotes first-intron splicing: ZC3H18 recruits splicing factors while competing with the RNA-decay machinery, linking two alternative fates for newly made RNA. doi.org/10.1016/j.mo...
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Courtney Milan @courtneymilan.com · 28/09/2026
As an affirmed dog lover, I have a few things to say. (1) Dogs are harder than people admit. They take a lot of work. They need constant exercise and mental stimulation, especially those with working dog heritage of any kind. Dogs are hard.
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BWJones @bwjones.bsky.social · 25/09/2026
Science peeps: Looks like SciENcv updated the digital certificate used to sign Biosketch and Current & Pending documents without notification. The old certificate expires Saturday, September 26, 2026. SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
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Harmit Singh Malik @harmitmalik.bsky.social · 25/09/2026
Tenure process in the age of Trump and Vought
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Josh Chafetz @joshchafetz.bsky.social · 24/09/2026
There's a lot to say about this, and other folks are saying most of it. I just want to focus on one thing: the claim about the relationship between universities and "the real world."
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Dave Palmer @davepalmerusask.bsky.social · 23/09/2026
Selective inhibitors targeting midichlorian glycolysis can prevent early-onset Jediism in pre-adult Tatooinians.
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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 22/09/2026
NIH funding decisions should be made by scientific experts, not political appointees. Protecting rigorous peer review safeguards public trust, biomedical progress and U.S. scientific leadership. ➡️Learn more: www.asbmb.org/advocacy/pos... #ScienceServesUsAll #ASBMBAdvocates
Graphic reading "Science Serves Us All" over a blue scientific background with the ASBMB logo.
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 22/09/2026
New from @timwrhoads.bsky.social lab! #RNAsky
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Drug Monkey @drugmonkey.bsky.social · 22/09/2026
in truth this is less about UC homerism and more about pointing out that public support for Universities, sustained over generations, creates wonderful things and the right wing attacks on them (including whiny math professors) are unwarranted given the good these efforts do for students.
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 22/09/2026
Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brain www.biorxiv.org/content/10.64898/20…
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Charlotte Clymer @charlotteclymer.bsky.social · 20/09/2026
Oh my dear god, let your college kids fail. Let them fail courses. Let them fail paying rent. Let them fail doing their laundry. Let them fail basic hygiene. Let them fail and experience consequences. www.nytimes.com/2026/09/13/w...
nytimes.com
Worried About Your College Kid? Now You Can Hire a Local Mom. (Gift Article)
At some universities, parents can pay to make sure their children are cared for, the way they were back home.
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Ian Sudbery @iansudbery.bsky.social · 12/09/2026
Holy moly, @ensembl.org killed biomart! Hope many R scripts are there out there that depend on biomaRt? How many people have informatics practicals, or undergraduate project instructions that depend on a web interface for bulk selection of data?
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Osman Lab @osman-lab.bsky.social · 29/08/2026
🧬 New preprint from our lab! After years of work, we're excited to share our story: the pyruvate dehydrogenase complex (PDHc) — best known for feeding the TCA cycle — has a second, non-catalytic role supporting mitochondrial DNA gene expression in yeast.
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Kurianlab @kurianlab.bsky.social · 11/09/2026
www.biorxiv.org/content/10.6... check this from @osman-lab.bsky.social !
biorxiv.org
RNA-dependent association of the pyruvate dehydrogenase complex with mtDNA-containing assemblies supports mitochondrial translation
Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...
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British Society for Research on Ageing @bsrageing.bsky.social · 10/09/2026
Annnnnddddd Day 1 is a wrap! ECR communication training, keynotes talks, some great science shared, and an engaging public lecture before @dweinkove.bsky.social hosted a Chairs Reception in the stunning dining hall at @kebleoxford.bsky.social. What was your favourite part of day 1? #BSRA2026
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Gabrijela Dumbović @gabrijelad.bsky.social · 09/09/2026
Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? www.nature.com/articles/s41...
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Journal of Cell Biology @jcb.org · 09/09/2026
Jessica Sheu-Gruttadauria et al. show that the material properties of the #nucleolus are shaped by the assembly state of ribosomal precursors, which tune nucleolar dynamics and morphology through their interactions with the nucleolar scaffolding protein NPM1. rupress.org/jcb/article/... #Biophysics
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The Company of Biologists @biologists.bsky.social · 07/09/2026
Save the date - @dev-journal.bsky.social, @jcellsci.bsky.social and @dmmjournal.bsky.social are holding a meeting on #Metabolism 📅21 – 23 June 2027 📍St Mary’s Marylebone, London, UK Register your interest for #BiologistsMetabolism now www.biologists.com/meetings/met...
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Ying Ge @yingge2121.bsky.social · 05/09/2026
AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry | Science Advances www.science.org/doi/10.1126/.... Congrats to my Marie Curie postdoc fellow, Boris, and all co-authors! 👏 @science.org #kinase #AMPK @proteoforms.bsky.social
science.org
AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry
Protein kinases integrate cellular signals through complex phosphorylation cascades, yet resolving how chemical perturbations trigger and modulate these cascades in therapeutic targets remains a major...
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Genetics Society UK @gensocuk.bsky.social · 08/09/2026
Next up is Timothy Rhoads talking about splicing factor engagement and regulation of RNA processing during caloric restriction,
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Ayush Midha @ayushmidha.bsky.social · 02/09/2026
New preprint! www.biorxiv.org/content/10.6... We uncovered surprising roles for a little-known metabolic pathway, branched-chain amino acid fermentation, with implications for hypoxia, mitochondrial dysfunction, alcohol toxicity, and fertility.
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Colin Carlson @colincarlson.bsky.social · 07/09/2026
This, I think, is the heart of the problem with MAHA reconciliation and Trump administration apologia: it all makes it easier for Dems to fire just RFK, or just RFK and just Jay, rather than clear the entire house when they take power. And they have to. There are lab leak nuts screening proposals.
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Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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Elle Cordova @ellecordova.bsky.social · 03/09/2026
Rough Draft vs Final Draft
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Philip Ball @philipcball.bsky.social · 30/08/2026
It caught my eye because it exemplifies the mind-boggling complexity of gene regulation. I think it’s fair to say now that an understanding of the genome is much less about which genes are in it but how they are used and regulated. /2
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Nick Riley @nmriley.bsky.social · 28/08/2026
Glycoproteoforms are the unit of biological information in the glycoproteome, but measuring intact glycoproteins to capture combinatorial modification states remains a huge #glycotime challenge. @timveth.bsky.social tackled this issue head on in the latest preprint from @riley-research.bsky.social
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Claudio Paganini @thehappyproton.bsky.social · 26/08/2026
The real brain drain in the US academic institutions isn't the superstar scientists who leave, it is the students who never come.
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Ashley Webb, PhD @aewebb.bsky.social · 21/08/2026
The abstract deadline is coming up for the FASEB on Epigenetics and Aging! Oct 19-22 in Malahide, Ireland. Submit now to be considered for a short talk! Amazing lineup including Yang Shi @denadubal.bsky.social @brunetlab.bsky.social @bbparis1984.bsky.social and more! events.faseb.org/event/Chroma...
events.faseb.org
Home - Chromatin and Epigenetics in Aging and Disease
Discover how epigenetics and transcription shape aging and disease, with new tools, therapies, and collaborations at this leading conference.
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Cole Donovan @colesci.bsky.social · 24/08/2026
My analysis of the emerging fiscal crisis and its impact on technology policy. Science and tech policy is the source of solutions to many of America's most vexing problems, and we can't afford not to make those investments. Advocates need to engage directly to make the case for our country's future.
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 23/08/2026
Just a reminder about 3 weeks left to register for Physics of Life at the Nanoscale! Conference will be Jan. 3-8 at the Aspen Center for Physics! More information here sites.google.com/view/pln2027
sites.google.com
Physics of Life at the Nanoscale
The Physics of Life at the Nanoscale Conference, 2027
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Alexis A. Jourdain @jourdainlab.bsky.social · 20/08/2026
New paper from the lab! 🎉 In this new story, we venture into the fascinating world of macrophage immunometabolism. Beautiful work led by Joan Blanco I Fernandez the lab’s very first PhD student & macrophage expert! Have a look for more! 👇 www.science.org/doi/10.1126/...
science.org
Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response
Mitochondria drive cellular reprogramming by integrating metabolism and signaling. In macrophages, mitochondria are central to immunometabolic responses to external cues, but the extent to which they ...
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Drug Monkey @drugmonkey.bsky.social · 19/08/2026
#icymi
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Luis Cedeño-Rosario, PhD @luisci22.bsky.social · 14/08/2026
It is NOA day! 🎉 I feel blessed and excited to receive the K99/R00 from NIH NIGMS! Thanks to everyone who has supported me and continues to support me on this journey. I appreciate you all! 🙏🏾✨🧪 @uofubiochem.bsky.social @rutterlab.bsky.social
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William Garland @willgarland.bsky.social · 14/08/2026
Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...
au.dk
Postdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet
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Craig Kaplan @triggerloop.bsky.social · 14/08/2026
My view is that this proposal coming out now cannot be considered in a vacuum. It should be considered a tool to subvert peer review of NIH proposals. The statements in the RFI about impact scores are actually correct- they are imperfect measures. But reporting them maintains transparency.
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vincentholst.bsky.social @vincentholst.bsky.social · 13/08/2026
In 2023, @nature.com published 'Papers and patents are becoming less disruptive over time', receiving world-wide media attention. Our Matters Arising, published after a 32 month delay (more on that soon), shows that the reported decline can largely be attributed to dataset artefacts. 🧵
The average CD_5 index per year for Web of Science. The original Park et al. decline (top curve) becomes essentially flat (bottom curve) when removing papers with CD_5=1. Those papers largely correspond to dataset artefacts.
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Jeff Watson @lifeat78rpm.com · 12/08/2026
We are hiring a tenure-track position (organic and/or biochemistry) this fall! Head to the link below for more information. Come join us! I am not on the search committee, but I'd be happy to answer questions. employment.gonzaga.edu/jobs/assista...
employment.gonzaga.edu
Assistant Professor, Chemistry - Gonzaga Main Campus, Washington, United States
Title: Assistant Professor, Chemistry Area: College of Arts and Sciences Department: Chemistry and Biochemistry Telework Availability: On-campus Position Employee Classification: Tenure Track Faculty ...
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Mark Meyer @markmeyerlab.org · 10/08/2026
Our new story on how FGF23 regulates the genome and how both FGF23 and PTH control #vitaminD in kidney is finally up after years of work. Available on #researchsquare preprint server while under review: www.researchsquare.com/article/rs-1... @uwmadison.bsky.social @uwmadisonnutrisci.bsky.social
researchsquare.com
ETV1 Couples Reciprocal FGF23 and PTH Signaling to Renal CYP24A1 Regulation
Active vitamin D [1,25(OH)2D3; 1,25D] synthesis is finely balanced in kidney proximal tubules by the catabolic enzyme CYP24A1 and anabolic CYP27B1. Fibroblast growth factor 23 (FGF23) and 1,25D lower ...
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boehninglab @boehninglab.com · 10/08/2026
Someone needs to FOIA the citizenship/visa-status data on K99/R00 awardees
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Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 10/08/2026
Spread the word! Registration is open for The Physics of Life at the Nanoscale meeting at the Aspen Center for Physics, Jan 3-8, 2027! This is an evolution of the popular Single Molecule Biophysics meetings (SMB). As always, there is a two step registration. Registration closes on Sept. 15, 2026!
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Lempradl Lab @lempradllab.bsky.social · 07/08/2026
Scientific careers are rarely linear, and mine is a good example. I am grateful to @natmetabolism.nature.com for publishing this series and making space for the many different paths, timelines and ways to build a scientific career. rdcu.be/fysBT #Drosophila #CareerPathways #WomenInSTEM #ScienceSky
rdcu.be
Career pathways, part 20
Nature Metabolism - Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities....
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Dannagal Goldthwaite Young @dannagal.bsky.social · 06/08/2026
If you send me an automated zoom/teams invite without having communicated with me in advance to arrange schedules or to see if I’m free or interested in meeting with you, I will assume you want to be my enemy.
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Drug Monkey @drugmonkey.bsky.social · 05/08/2026
and drugmonkey.wordpress.com/2026/06/09/n...
drugmonkey.wordpress.com
NIH seeks input on capping grant awards
The NIH has posted a request for input on a proposal to limit the number of grant awards a given PI may hold at any one time. NOT-OD-26-086 Request for Information: Proposal to Cap the Number of Si…
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Quanta Magazine @quantamagazine.org · 02/08/2026
Can AIs actually reason, or does that involve some wishful thinking? www.quantamagazine.org/is-ai-reason…
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Natalie Niemi @nieminm.bsky.social · 02/08/2026
New preprint from the lab, co-led by Youmian Yan and @lianjiejerrywei.bsky.social! 🧵 at some point in the near future, but until then, check out our work uncovering mechanisms allowing the dual targeting of mitochondrial proteins using our favorite, PPTC7, as a case study.
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Kathrin Leppek @katleppek.bsky.social · 01/08/2026
It's an RNA World. We just live in it. Happy World RNA Day!
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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 01/08/2026
⏯️Webinar replay: Everything you wanted to know about pre-mRNA splicing but were afraid to ask 🎤 Speaker: Aaron Hoskins, @uwmadisonrna.bsky.social Watch for an overview of pre-mRNA splicing and the cellular machine responsible — the spliceosome: www.youtube.com/watch?v=Hf2w.... #RNAResearch
youtube.com
Everything you wanted to know about pre-mRNA splicing but were afraid to ask
YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)
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PROFS @profsuwmadison.bsky.social · 28/07/2026
Early voting for the August 11 is open. We asked candidates in the 76th Assembly District (isthmus and northeast Madison) and the 17th Senate District (southwestern Wisconsin) for their positions on higher education, cuts in research funding, family leave and other important issues. profs.wisc.edu
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Stirling Churchman @stirlingchurchman.bsky.social · 28/07/2026
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
biorxiv.org
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
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I-75 Scientist @flscitriguy.bsky.social · 28/07/2026
For those interested in applying for an R25 (PA-27-036) to support Summer UG Research, Postbac, or even masters students, additional information on NIGMS priorities and some FAQs can be found here: www.nigms.nih.gov/training/Pag...
nigms.nih.gov
Research Education Program - Research Experiences (R25) | National Institute of General Medical Sciences
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