Background Despite the growing demand for transplantation, a shortage of donor organs persists, limiting access to this lifesaving procedure. To meet the increasing demand, organs are frequently trans...

The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are i...

Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its mo...

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

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Nature Communications - In search of LncDACH1 – a perceived intronic long non-coding RNA lacking fundamental genomic annotation evidence

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis. Bac...

Emmy Noether, whom some consider the “Mother of Modern Mathematics,” continues to shape modern research and the studies of mathematicians today; including research into the investigation of airplane c...

Nobel laureate persisted despite widespread derision and revolutionized structural biology by protecting fragile crystals.

Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

How post-transcriptional mechanisms shape the mammalian body plan remains unclear. Here, the authors establish a single-cell CRISPR screening platform in gastruloids to identify Cnot8-dependent mRNA d...

Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...