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Osman Lab

@osman-lab.bsky.social
297 followers 287 following 43 posts

Studying the mysteries that surround the genome of the cell's powerhouse www.osman-lab.de

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Reposted by Osman Lab
KunzLab@LMU @kunzlab.bsky.social · 01/09/2026
Emmy Noether grant for biologist Sofia Doello www.bio.lmu.de/en/latest-ne...
bio.lmu.de
Emmy Noether grant for biologist Sofia Doello
The researcher will use the prestigious grant to investigate how microorganisms reactivate their metabolism after prolonged dormancy.
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Reposted by Osman Lab
LMU München @lmu.de · 31/08/2026
How do plants prepare for an attack?🌱 A team led by Hans-Henning Kunz @kunzlab.bsky.social identified ion channels in chloroplasts that play a key role in connecting early stress signaling with the plant’s defense machinery. This can help them to respond faster & more strongly when stress returns.
lmu.de
Important role of plastid ion channels in plant stress response identified
LMU researchers have shown that specific ion channels enable rapid transmission of calcium signals to chloroplasts and strengthen the defense response to recurring stress.
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Osman Lab @osman-lab.bsky.social · 29/08/2026
🧬 New preprint from our lab! After years of work, we're excited to share our story: the pyruvate dehydrogenase complex (PDHc) — best known for feeding the TCA cycle — has a second, non-catalytic role supporting mitochondrial DNA gene expression in yeast.
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KunzLab@LMU @kunzlab.bsky.social · 29/08/2026
New PEC story 🌱 led by PhD cand Susi with amazing collabs Grimm, Hause & Robatzek labs! We patch-clamped isolated plastids to show that PECs mediate rapid cation flux across the IE. PECs relay Ca²⁺ signals into plastids & link Ca²⁺ to JA-mediated defense. #plantscience www.pnas.org/doi/10.1073/...
Model of chloroplast Ca²⁺-mediated priming: after a stress trigger, plants show a larger stromal Ca²⁺ signal via PEC1, boosting OPDA and JA production and enhancing defense gene expression compared to baseline
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KunzLab@LMU @kunzlab.bsky.social · 01/07/2026
Congrats @lifescimunich.bsky.social PhD thesis awardees. Terrific job! @lmu.de
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Mokranjac Lab @mokranjaclab.bsky.social · 13/04/2026
Interested to know how #mtHsp70 looks inside #mitochondria and what that means for #mitochondrial #proteostasis and #stress #signalling? Take a look at our latest publication in @pnas.org 🥳🥳 @osman-lab.bsky.social doi.org/10.1073/pnas...
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Juan C. Landoni @jclandoni.bsky.social · 03/04/2026
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
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Stella Hurtley @smhsci.bsky.social · 07/04/2026
Out now in @science.org Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...
science.org
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
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The EMBO Journal @embojournal.org · 26/03/2026
What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...
link.springer.com
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
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Yasin Dagdas @plantophagy.bsky.social · 25/03/2026
Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
link.springer.com
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
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Elif Karagöz @gekaragoz.bsky.social · 25/03/2026
Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!
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Hansi Weissensteiner @whansi.bsky.social · 17/03/2026
Emerging mechanisms of genome degradation during the mtDNA life cycle www.nature.com/articles/s41...
nature.com
Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology
Mitochondrial DNA (mtDNA) is not static but undergoes a regulated ‘life cycle’ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...
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New Phytologist @newphyt.bsky.social · 16/03/2026
The New Phytologist Foundation is pleased to sponsor the 39th Molecular Biology of Plants Conference! The conference takes place in Hennef, Germany, this week. www.pflanzen-molekularbiologie.de/conference-m... @molplantsci.bsky.social #PlantScience #MBP2026
pflanzen-molekularbiologie.de
Conference
Conference "Molecular Biology of Plants" - Annual meeting of the Section Plant Physiology and Molecular Biology in the German Society for Plant Sciences (DBG)
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Osman Lab @osman-lab.bsky.social · 15/03/2026
We have officially launched our new lab website. 🥳 The site includes the automated literature curation on #mtDNA quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest #NotebookLM generated podcast. 🧬 Explore the new site: osman-lab.de
osman-lab.de
The Osman Lab | LMU Munich
Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.
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Osman Lab @osman-lab.bsky.social · 13/03/2026
Daily #mtDNA intel: • AK4-mediated synthesis fuels macrophage immunity 🧬 • T cell mutations found post-chemotherapy • Osteomodulin suppresses osteoclast respiration 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 11/03/2026
Daily #mtDNA intel: • Structural partitioning improves phylogenetic signals 🧬 • Transmembrane helices show conserved thymine/hydrophobic bias 🔬 • New #nematode mitogenome data. 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 09/03/2026
Daily #mtDNA intel: • PS1 in inner membrane regulates cristae & mtDNA stability 🧬 • MitoMetrics refines forensic likelihood ratios • SMC loss linked to MELAS dysmotility 🔬 #Genetics 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 07/03/2026
Daily #mtDNA intel: • Most axonal mitochondria lack mtDNA/ATP 🧬 • ROS impairs lysosomal flux in human APOE4 cells • Mitogenome variants impact Parkinson's progression 🔬 #Neuro 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 05/03/2026
Daily #mtDNA intel: • Fumarate loss activates cGAS-STING 🧬 • MT-CO2 m.8024G>A drives bioenergetic failure • mtDNA background impacts pS65-Ub in Lewy body disease 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 04/03/2026
Daily #mtDNA intel: • C24-Ceramide-VDAC1 binding triggers hypoxic mtDNA release 🧬 • TFAM roles mapped across pan-cancer types • Melatonin identified as a mitochondrial radioprotectant 🔬 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 03/03/2026
Daily #mtDNA intel: • Liver mitochondria drive systemic inter-organ aging 🧬 • cGAS-STING blockade preserves tendon stem cell fitness • ZBP1 promotes RIPK1-dependent apoptosis 📄 Full Dossier | 🎙️ Podcast
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TDvaliLab @tdvalilab.bsky.social · 02/03/2026
#C.elegans is about to join the 'centriolar satellites' club. Check out our new preprint #centriolarsatellites: www.biorxiv.org/content/10.6...
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Osman Lab @osman-lab.bsky.social · 02/03/2026
Daily #mtDNA intel: • MAF1 inhibits AIM2 by sequestering host mtDNA 🧬 • Cytoskeleton loss dysfunctions B-ALL mitochondria • LRRK2 G2019S drives oxidative DNA damage 🔬 #CellBio #Genetics 📄 Full Dossier | 🎙️ Podcast
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Nature Structural & Molecular Biology @natsmb.nature.com · 27/02/2026
New online: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
dlvr.it
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Nature Structural & Molecular Biology, Published online: 27 February 2026; doi:10.1038/s41594-026-01756-0Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.
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Osman Lab @osman-lab.bsky.social · 27/02/2026
Daily #mtDNA intel: • APOL3 mediates mtDNA efflux via lysosomal damage • ALS blood/CSF mtDNA indices profiled 🧬 • CRISPR-guided biogenesis in iPSC-CMs 🔬 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 26/02/2026
Daily #mtDNA intel: • TFAM replication vital for oocyte competence 🧬 • Hypoxia triggers APOBEC3A-mediated DNA damage • Aging reduces muscle resilience after disuse #MitoSci 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 25/02/2026
Daily #mtDNA intel: • PRMT5 regulates stability via TFAM methylation 🧬 • Leakage triggers cGAS-STING neuroinflammation • Mitophagy failure promotes release in selenium deficiency 🔬 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 24/02/2026
Daily #mtDNA intel: • 4,5-DHA validated as robust disease marker • Single-cell lineage tracing via inheritance modeling • ROS quenching suppresses cGAS-STING signaling 🧬🔬 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 23/02/2026
Check out today's mtDNA research briefing! 📄 Full Dossier | 🎙️ Podcast
Daily mtDNA Research Briefing Header
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Osman Lab @osman-lab.bsky.social · 20/02/2026
Daily #mtDNA intel: • Cardiospecific POLG loss drives cardiomyopathy 🧬 • EV-mediated mtDNA transfer triggers osteoarthritis • Gstk1 inhibits cGAS/STING in sepsis 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
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Kurianlab @kurianlab.bsky.social · 20/02/2026
www.science.org/doi/10.1126/...
science.org
Rapid directed evolution guided by protein language models and epistatic interactions
Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...
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Reposted by Osman Lab
Andreas P.M. Weber 🌾🌱🧬 @apmweber.bsky.social · 20/02/2026
This argues against the hydrogen hypothesis of mitochondrial origin. 👇 www.nature.com/articles/s41... See also this excellent context (including a microscopy 🔬movie of crawling Asgards) by @carlzimmer.com: www.nytimes.com/2026/02/18/s...
nature.com
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...
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Osman Lab @osman-lab.bsky.social · 19/02/2026
Daily #mtDNA intel: • Single-cell lineage tracing via inheritance 🧬 • USP10-MTX2 axis regulates cGAS-STING signaling • EV mtDNA transfers drive osteoarthritis 🔬 📄 Full Dossier | 🎙️ Podcast
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Carl Zimmer @carlzimmer.com · 18/02/2026
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22
A pilot in a submersible vehicle collecting sediments samples in 30 meters of water looking for Asgards (microbial relatives of eukaryotes)
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Martin Ott lab @mitolab.bsky.social · 28/01/2026
We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us: martinottlab.com Apply here: web103.reachmee.com/ext/I005/103...
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Osman Lab @osman-lab.bsky.social · 17/02/2026
Daily #mtDNA intel: • Mito transfer fuels tumor pyrimidine synthesis 🧬 • mtDNA dsRNA drives aging-associated cognitive decline • Novel 12244G>A variant linked to MELAS phenotype 🔬 📄 Full Dossier | 🎙️ Podcast
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Florian Fröhlich @flofroehlich.bsky.social · 16/02/2026
New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1. www.biorxiv.org/content/bior...
bsky.app
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Osman Lab @osman-lab.bsky.social · 16/02/2026
Daily #mtDNA intel: • dsRNA drives aging-linked cognitive decline 🧬 • EV mtDNA transfer triggers osteoarthritis • ANOMALY pipeline identifies NuMTs in long-read data 🔬 #Bio #Genetics 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 15/02/2026
Daily #mtDNA intel: • Gstk1 inhibits cGAS/STING in septic hearts 🧬 • LL37-mediated mtDNA stress drives rosacea 🔬 • Nanosystems enable mtDNA control for wound repair 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 14/02/2026
Daily #mtDNA intel: • mtDNA inheritance enables lineage tracing 🧬 • LONP1 variants linked to diverse phenotypes • HSP90α/DRP1 axis triggers sepsis brain injury 🔬 #mitochondria 📄 Full Dossier | 🎙️ Podcast
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Amanda Moehring @flybehaviour.bsky.social · 13/02/2026
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself. www.science.org/doi/10.1126/...
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Osman Lab @osman-lab.bsky.social · 13/02/2026
Daily #mtDNA intel: • RNA G-quadruplexes brake OXPHOS assembly 🧬 • EV-mediated mtDNA transfer drives osteoarthritis • Photoactivatable POLRMT inhibition targets cancer 🔬 #CellBio 📄 Full Dossier | 🎙️ Podcast
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Joanna Chustecki @chusteckisci.bsky.social · 12/02/2026
All together now 🗣️🗣️ : mitochondrial dynamics are vital *even in plants*! 🗣️🗣️ Fantastic work looking looking at the prime candidate for the mysterious & elusive plant mito fusion factors: MIRO1 The momentum for plant mito dynamics is picking up 💪🏻 www.nature.com/articles/s41...
nature.com
Mitochondrial fusion safeguards stomatal defence in plants - Nature Plants
Plants close their stomata to block pathogen entry, but how this defence is supported at the organelle level remains unclear. Our study reveals that immune signalling promotes MIRO1-dependent mitochon...
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Osman Lab @osman-lab.bsky.social · 12/02/2026
Daily #mtDNA intel: • Nanosystems modulate mtDNA levels for healing • LONP1 variants linked to diverse phenotypes • MBD5/6 loss impairs respiration via chromatin 🧬 #genetics #biology 📄 Full Dossier | 🎙️ Podcast
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Hana Antonicka @hantonicka.bsky.social · 11/02/2026
To all #mitochondria lovers: Euromit 2026 early-bird registration is coming up!
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Andreas P.M. Weber 🌾🌱🧬 @apmweber.bsky.social · 10/02/2026
🧬⚡ Call for abstracts & participants | GRC 2026 ⚡🧬 Together with Vamsi Mootha, I’m chairing the 2026 Gordon Research Conference on Mitochondria & Chloroplasts (July 19 - 24, 2026). We’d love to see your application. Thread 🧵👇
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Osman Lab @osman-lab.bsky.social · 11/02/2026
Daily #mtDNA intel: • Ageing drives indel accumulation in energetic tissues • Cytosolic mtDNA triggers NLRP3 in Parkinson's models • ANOMALY pipeline improves NuMT detection 🧬 #genetics 📄 Full Dossier | 🎙️ Podcast
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Osman Lab @osman-lab.bsky.social · 10/02/2026
Daily #mtDNA intel: • Molybdenum blocks cGAS-STING in pancreatitis 🔬 • EV-mediated mtDNA transfer drives osteoarthritis • ANOMALY tool detects NuMTs via long-read seq 🧬 #Genetics 📄 Full Dossier | 🎙️ Podcast
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LMU München @lmu.de · 09/02/2026
#Photosynthesis 🌿: A team led by #LMU biologist Hans-Henning Kunz has now deciphered the chloroplast ionome of various plant species. Their findings form an important basis for elucidating the regulation of mineral homeostasis in chloroplasts & developing new biotech strategies.
lmu.de
Photosynthesis: new insights into mineral homeostasis of chloroplasts
LMU biologists decipher the ionome of chloroplasts and create the foundations for new biotech strategies.
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LSM @lifescimunich.bsky.social · 20/02/2025
Check out our new newsletter!!🎊❤️ Kudos to the newsletter team for their efforts!🎊
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