Mitochondria drive cellular reprogramming by integrating metabolism and signaling. In macrophages, mitochondria are central to immunometabolic responses to external cues, but the extent to which they ...

A research group at Unil has identified a new mechanism that exposes the vulnerability of tumor cells when they are deprived of vitamin B7.

Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...

Professeur assistant à la FBM, Alexis Jourdain a été sélectionné pour l’EMBO Young Investigator Programme. Cette distinction offre au spécialiste du métabolisme un soutien important pour consolider le...

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

Des scientifiques du Département d’immunobiologie de l’Unil mettent en évidence un nouveau mécanisme susceptible de faire dérailler certains traitements du cancer.

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)

Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

12 Laboratoires ont reçu une certification LEAF (Laboratory Efficiency Assessment Framework) pour leur participation au programme de mai 2024 à mai 2025.

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Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

The controversial metric will be removed because the journal’s new publishing model doesn’t meet its quality criteria