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DMM Journal

@dmmjournal.bsky.social
3.5K followers 114 following 566 posts

Disease Models & Mechanisms - discovery for human health. A @biologists.bsky.social Open Access journal that publishes human disease research.

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preLights @prelights.bsky.social · 5h
Did you ever wonder how the leopard got its spots? Or how the zebra got its stripes? Wonder no more! In this #Short, @benswedlund.bsky.social talks about his #preprint describing reaction-diffusion architecture for engineering self-organised patterns in mammalian cells. 🎙️⬇️ youtu.be/_HMbr4KE1PI?...
youtu.be
spotLights Ep 23: Benjamin on programming self-organising cell patterns #syntheticbiology #biology
YouTube video by The Company of Biologists
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DMM Journal @dmmjournal.bsky.social · 5h
With #ZDM19 coming to an end today, check out our growing collection of #zebrafish research and review-type articles: journals.biologists.com/dmm/collecti... @zdmsociety.bsky.social
journals.biologists.com
Zebrafish as a Disease Model | Disease Models & Mechanisms | The Company of Biologists
The zebrafish is a powerful research tool for investigating vertebrate developmental biology and disease pathology through both large-scale and high-precis
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DMM Journal @dmmjournal.bsky.social · 29/09/2026
Excited to see Ewa Snaar-Jagalska talk today at #ZDM19? Check out her recent #DMMPerspective article with Gabriel Forn-Cuní, Bruno Lopes-Bastos, David Langenau & Liz Patton on the evolution of #zebrafish models of #cancer doi.org/10.1242/dmm.... @zdmsociety.bsky.social
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DMM Journal @dmmjournal.bsky.social · 28/09/2026
We are delighted to be sponsoring #ZDM19 in Oxford this week! Our Senior Editor @kirstyhooper.bsky.social is attending so feel free to stop her for a chat and you can come by our table to grab some freebies too 🐟️ @zdmsociety.bsky.social
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DMM Journal @dmmjournal.bsky.social · 26/09/2026
Survivin drives tumor growth and migration via proliferative and metabolic adaptation and could be a therapeutic target for #RenalCellCarcinoma. Read the article by Shivani Tuli & co for free: doi.org/10.1242/dmm....
Protein–protein interaction (PPI) network of upregulated DEGs constructed using the STRING database
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DMM Journal @dmmjournal.bsky.social · 25/09/2026
What does patient involvement in cancer research really look like? Submit an article for the EACR Science Communication Prize 2026 @helloeacr.bsky.social. Enter by 9 November via magazine.eacr.org/what-does-pa...
magazine.eacr.org
EACR Science Communication Prize 2026
Have you ever involved patients in your cancer research? We want to hear about it!
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EACR - European Association for Cancer Research @helloeacr.bsky.social · 24/09/2026
Better research starts with listening. In honour of #WorldCancerResearchDay the EACR Science Communication Prize 2026 is inviting researchers to share real-life examples of patient involvement & the impact it has had on their work. Submission deadline: 9 Nov 2026 magazine.eacr.org/what-does-pa...
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DMM Journal @dmmjournal.bsky.social · 24/09/2026
Today is #WorldCancerResearchDay with the theme "Advancing Cancer Research Together". In our interview with Liz and Jay Scott, founders of Alex's Lemonade Stand Foundation, they discuss the unique challenges in childhood cancer research. journals.biologists.com/dmm/article/...
Jay (left) and Liz (right) Scott.
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DMM Journal @dmmjournal.bsky.social · 23/09/2026
Dreyer @tjdreyer.bsky.social and colleagues validate Sost−/− mice as a valuable model for investigating potential treatments for #sclerosteosis and other HBM related conditions. doi.org/10.1242/dmm.... @drsjroberts.bsky.social @royalvetcollege.bsky.social
A) Image showing a trans-axial cross-section of a 9-month-old female Sost−/− mouse skull; the ossicles region of interest is highlighted in white within the boxed area. (B) Representative 3D microCT images of the ossicles in the middle ear of male (top) and female (bottom) BL6 (left) and Sost−/− (right) mice aged 9 months. Arrowheads indicate regions with a visible increase in bone.
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DMM Journal @dmmjournal.bsky.social · 22/09/2026
Michelle Curley & co establish #Drosophila and #MouseModels of spinal muscular atrophy X-linked 2 and identified regulated proteins that may contribute to disease pathogenesis Check out the article for free in DMM: doi.org/10.1242/dmm....
UBA1 knockdown reduces protein ubiquitination in Drosophila melanogaster and mouse skeletal muscles but primarily affects the levels of a limited set of proteins (‘UBA1-sensitive proteins’) that rely on optimal UBA1 levels for their turnover and stability.
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Reposted by DMM Journal
Development @dev-journal.bsky.social · 21/09/2026
At Development, we #LovePostdocs. For #NPAW2026, we highlight our 2026 cohort of Pathway to Independence fellows. Read about their unique journeys as they work to secure independent positions, their excitement about the latest advances in their fields & the advice they have received along the way.
journals.biologists.com
Dev | PI fellows 2026 | Development | The Company of Biologists
Dev | PI fellows 2026 | Development | The Company of Biologists .card-list-container { margin-top: 2em; } .card-list-container h2 { margin-bottom: 1em; } .ca...
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DMM Journal @dmmjournal.bsky.social · 21/09/2026
This #PostdocAppreciationWeek #NPAW2026 we are celebrating our #FirstPerson interviews. These interviews spotlight the first authors of a selection of papers published in DMM, helping researchers promote themselves alongside their papers. Browse the collection: tinyurl.com/3n8zwyxf
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DMM Journal @dmmjournal.bsky.social · 19/09/2026
For your #WeekendRead during #ChildhoodCancerAwarenessMonth, revisit this vital research on fusion-driven paediatric soft tissue sarcomas by Jack P. Kucinski and colleagues. doi.org/10.1242/dmm.... #CCAM🎗️
doi.org
Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomas
Summary: Fusion-driven pediatric soft tissue sarcomas are aggressive and lack targeted therapies. Transgenic fusion-driven animal tumor models are a platform to understand tumorigenic mechanisms and…
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DMM Journal @dmmjournal.bsky.social · 18/09/2026
We have joined our sister journals, @dev-journal.bsky.social , @jcellsci.bsky.social and @biologyopen.bsky.social, in offering a fast track option. If you have a paper with reviews from another journal, Disease Models & Mechanisms can use them to fast track a decision on your paper. #PRW2026
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DMM Journal @dmmjournal.bsky.social · 17/09/2026
“The process of publishing this article was smooth, straightforward, and responding to the reviewers comments made the study better. Thank you so much for selecting it for the Editor’s Choice!” - Kirsten Sadler, New York University Abu Dhabi We’re proud to have many happy authors at DMM. #PRW2026
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DMM Journal @dmmjournal.bsky.social · 17/09/2026
KRAS–PI3Kα signaling promotes pathological lymphatic vessel enlargement, whereas KRAS–MAPK signaling disrupts lymphatic valve formation. Read the article by Fernandes & co for free: doi.org/10.1242/dmm....
Schematics of the KrasG12D, Pik3caflox and Pik3caRBD alleles. Following tamoxifen administration, mice have either a single wild-type (Pik3cawt/Δ) or mutant Pik3ca allele (Pik3caRBD/Δ) in their LECs. They also express KrasG12D in their LECs.
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DMM Journal @dmmjournal.bsky.social · 16/09/2026
#DidYouKnow that DMM encourages co-reviewing? PIs - involve post-docs and other early-career scientists in your peer review process! #PeerReviewWeek #PRW2026 Find out more in our reviewer guide journals.biologists.com/dmm/pages/re...
journals.biologists.com
Reviewer guide | Disease Models & Mechanisms | The Company of Biologists
Reviewer guide | Disease Models & Mechanisms | The Company of Biologists
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DMM Journal @dmmjournal.bsky.social · 15/09/2026
"I very much appreciated the process of publishing our latest paper in DMM. I found the submission easy, the reviewers’ comments and requests were fair and helpful, and the production team very efficient." - Marion Jeanne, Genentech Inc., USA We’re proud to have many happy authors at DMM. #PRW2026
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DMM Journal @dmmjournal.bsky.social · 15/09/2026
Cerebellar organoids present promising tools for the modelling of human cerebellar development and diseases, including paediatric cancer #ChildhoodCancerAwarenessMonth #CCAM🎗️ Read the article by Becker & co for free: doi.org/10.1242/dmm....
doi.org
Generating cerebellar organoids from pluripotent stem cells
Summary: This Special Article provides a comprehensive overview of the methods, applications and considerations for the generation of cerebellar organoids.
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Reposted by DMM Journal
The Company of Biologists @biologists.bsky.social · 15/09/2026
A huge thank you to all our peer reviewers. Each digital tree in the #forestofbiologists represents a real-life tree in Great Knott Wood that is being protected, thanks to the important work of our peer reviewers. Check out the full on forest.biologists.com/landscape. #PRW2026 #PeerReviewWeek
4,570 trees for published articles

14,640 trees for peer reviews
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The Company of Biologists @biologists.bsky.social · 14/09/2026
We are pleased to welcome Dan Shanahan as our new CEO. Dan brings extensive publishing expertise and market knowledge to the role, with a strong background in Open Access publishing and non-profit organisations.Read more at www.biologists.com/stories/welc...
biologists.com
Welcome Dan Shanahan
The Company of Biologists is pleased to welcome Dan Shanahan as the new Chief Executive Officer, effective from 14 September 2026.
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DMM Journal @dmmjournal.bsky.social · 14/09/2026
#CharcotMarieTooth disease variants of HSPB1 decrease signalling in young animals and accelerate the aging process. Check out the Research Article for free by Iman Aolymat and Jeff W. Barclay: doi.org/10.1242/dmm....
Structural location of the wild-type residues for the Charcot–Marie–Tooth disease variants assessed in this study.
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DMM Journal @dmmjournal.bsky.social · 14/09/2026
Have a paper that's been reviewed elsewhere? DMM is pleased to consider such manuscripts for 'fast-track' decisions. Send us the manuscript together with the full set of reviews and decision letters, and we’ll use these to make a decision. Find out more at journals.biologists.com/dmm/pages/jo...
Fast track your paper with DMM. Do you have a paper with reviews from another journal? We can use them to fast track a decision on your paper.
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Biology Open @biologyopen.bsky.social · 14/09/2026
For this year's #PeerReviewWeek, we want to thank all the reviewers that have participated in BiO's Fast & Fair - an initiative that aims to provide authors with faster peer review decisions without compromising quality.
Biology Open's practice of compensating reviewers is rare and, in my view, contributes to a more respectful and high-quality review culture.
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DMM Journal @dmmjournal.bsky.social · 12/09/2026
For your #WeekendRead: The instructive scar – the dynamic role of extracellular matrix in biliary pathophysiology. Scott Waddell & co explore the mechanisms and roles of an altered extracellular matrix in cholangiopathies doi.org/10.1242/dmm....
Illustration showing shared pathophysiological processes across biliary diseases.
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DMM Journal @dmmjournal.bsky.social · 11/09/2026
Read the #FirstPerson interview with Kate Ding, who is now a Molecular Technician at Applied Spatial Omics Centre, University of Calgary, investigating how spatial organization in tissues and organs influences cellular responses to stress and disease. doi.org/10.1242/dmm....
Kate Ding
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DMM Journal @dmmjournal.bsky.social · 11/09/2026
In #Drosophila, the intestine releases the cytokine Upd3, which signals to the fat body and oenocytes to drive systemic hypoxia tolerance Read and share the article by Kate Ding & co for free: doi.org/10.1242/dmm....
Female flies expressing GFP under control of a upd3 promoter (upd3-Gal4, UAS-GFP) were exposed to hypoxia (1% oxygen) or maintained in normoxia for 16 h.
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DMM Journal @dmmjournal.bsky.social · 10/09/2026
Liking this #preLight: Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes prelights.biologists.com/highlights/d...
prelights.biologists.com
Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes - preLights
A common epigenetic circuit may unite genetically diverse Acute Myeloid Leukemia. Targeting the SAGA complex dismantles leukemic identity.
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DMM Journal @dmmjournal.bsky.social · 10/09/2026
Read the latest #AtAGlance article, by Thomas Willott and Silvia Marino @smarino0111.bsky.social. They highlight recent advances and current limitations of region-specific stem cell-derived organoids as models for #BrainTumour research. doi.org/10.1242/dmm....
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DMM Journal @dmmjournal.bsky.social · 09/09/2026
Restoring comparative expertise to improve translation of #AnimalModels: read the Editorial by K.C. Kent Lloyd doi.org/10.1242/dmm....
Historical drivers of the perceived translational gap between animal models and human disease
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DMM Journal @dmmjournal.bsky.social · 08/09/2026
Research is vital as current chemotherapeutics can cause severe adverse effects – especially if applied early on in life, as is the case in paediatric cancer patients. This #ChildhoodCancerAwarenessMonth, check out the article for free by Varady & co doi.org/10.1242/dmm.... #CCAM🎗️
doi.org
Precise photopharmacological eradication of metastatic tumor cells
Summary: We demonstrate that SBTubA4P enables spatially precise eradication of disseminated tumor cells in vivo and establish zebrafish xenografts as a well-suited model for preclinical evaluation of…
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DMM Journal @dmmjournal.bsky.social · 08/09/2026
Are you a PhD student interested in #SciComm, disease biology and publishing? Are you in the BBSRC DTP/PIPS or equivalent schemes where an internship forms part of the training? Join us as an intern and work with the DMM editorial team. Find out how to apply: www.biologists.com/about-us/wor...
biologists.com
Work for us
Explore career opportunities at The Company of Biologists. Join a team passionate about science, publishing and community support.
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DMM Journal @dmmjournal.bsky.social · 07/09/2026
August’s #EditorsChoice from Isles et al. on the placental defects revealed by modelling Prader–Willi syndrome in mice doi.org/10.1242/dmm....
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The Company of Biologists @biologists.bsky.social · 07/09/2026
Save the date - @dev-journal.bsky.social, @jcellsci.bsky.social and @dmmjournal.bsky.social are holding a meeting on #Metabolism 📅21 – 23 June 2027 📍St Mary’s Marylebone, London, UK Register your interest for #BiologistsMetabolism now www.biologists.com/meetings/met...
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DMM Journal @dmmjournal.bsky.social · 07/09/2026
Issue 8 is all yours! On the cover: Lymphatic vessels in mouse embryo skin visualised by immunostaining for neuropilin-2. See Research article by Dellinger et al. doi.org/10.1242/dmm....
doi.org
RAS–PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies
Summary: The somatic activating KrasG12D variant associated with complex lymphatic anomalies drives distinct phenotypes through separate pathways – KRAS–PI3Kα signaling promotes lymphatic vessel…
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DMM Journal @dmmjournal.bsky.social · 05/09/2026
#WeekendRead - Fzd2 regulates limb development and emphasizes the importance of thoroughly validating newly generated mouse models. Read Michalski & co’s article doi.org/10.1242/dmm....
Representative microCT reconstructions of adult mouse skulls showing lateral, ventral, frontal and dorsal views with annotated landmarks used for morphometric measurements.
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DMM Journal @dmmjournal.bsky.social · 04/09/2026
September is #ChildhoodCancerAwarenessMonth 🎗️ To mark #CCAM, we're spotlighting DMM content that centres paediatric cancer, beginning with our interview with Alex's Lemonade Stand Foundation @alexslemonade.bsky.social founders Liz and Jay Scott doi.org/10.1242/dmm....
You then have fragmented research, where each researcher is interested in a different cancer. We try to bring them together across cancers so that they can learn from each other; even if the exact treatment might not work, a technique or an approach might work from one cancer to the other.
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DMM Journal @dmmjournal.bsky.social · 04/09/2026
Early-bird registration is 11 September. www.cancerresearchuk.org/for-research...
t.co
https://www.cancerresearchuk.org/for-researchers/how-we-deliver-research/scientific-events-and-webinars/radiation-research-conference
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DMM Journal @dmmjournal.bsky.social · 04/09/2026
Amanda Friedman & co offer new insights into the complexity of Neurexin-1-associated #neurodevelopmental disorders. Check out this Resources & Methods article: doi.org/10.1242/dmm....
nrxn1a-α and -β transcripts have distinct brain expression patterns.
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FocalPlane @focalplane.bsky.social · 03/09/2026
We are excited to invite you to the second webinar in our cell migration series. In this webinar, we focus on new models for studying cell migration with talks from @ankita13jha.bsky.social, @raphclement.bsky.social & @katrinavelle.bsky.social. More info⤵️: focalplane.biologists.com/2026/09/03/f...
FocalPlane features... emergent models and quantitative analysis of cell migration
Thursday 17 September, 15:00-16:30 BST (UTC+1) 
Organised by Organised by Pablo J. Sáez and Valeria Venturini
FocalPlane logo
Picture of Ankita Jha (National Institutes of Health, USA)
Decoding bleb driven signaling in cancer disease progression
Picture of Raphaël Clément (L’Institut de Biologie du Développement de Marseille (IBDM), France)
Navigating without neurons or muscles: Locomotion in Trichoplax
Picture of Katrina Velle (University of Massachusetts Dartmouth, USA)
Naegleria amoebae seek confinement and crawl persistently through narrow spaces
#FocalPlaneFeatures
focalplane.biologists.com
Image of Naegleria.
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DMM Journal @dmmjournal.bsky.social · 03/09/2026
*** Call for papers deadline extended *** Submit your latest #Paediatric #GeneticDiseases paper to be included in our next special issue. The deadline has been extended to 7 December 2026. Find out more today 👇️ tinyurl.com/3b8zscaz
Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.
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The Company of Biologists @biologists.bsky.social · 03/09/2026
We are looking to recruit an Editorial Administrator to work across our portfolio of five life-science journals, with a particular focus on Journal of Cell Science. Deadline 4 September. Find out more and how to apply at www.biologists.com/about-us/wor...
biologists.com
Work for us
Explore career opportunities at The Company of Biologists. Join a team passionate about science, publishing and community support.
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DMM Journal @dmmjournal.bsky.social · 03/09/2026
A #Drosophila tumor model drives cancer cachexia and distant organ wasting through a conserved tumor–host signaling axis resulting in metabolic reprogramming. Read the article by Kewei Yu, Gurpreet Moroak and @estherverheyen.bsky.social for free doi.org/10.1242/dmm.... @sfuscience.bsky.social
Representative maximum-intensity projection confocal images of F-actin staining (gray), and GFP and Hipk (green) (tissues of interest are outlined with red dotted lines; n>4 for all discs).
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DMM Journal @dmmjournal.bsky.social · 02/09/2026
Familial LPL deficiency is a rare but serious disease. Ming Jing Wu & co’s study highlights the need to develop improved LPL variants for future gene therapy options. doi.org/10.1242/dmm....
Ribbon schematic of a protein structure showing helices and beta sheets, with an arrow and small red mark indicating the R297N mutation site on a surface-exposed loop.
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the Node @the-node.bsky.social · 02/09/2026
I don’t belong here: Thoughts of a first-generation academic @sillysciencelady.bsky.social discusses her experiences of belonging and the burdens that first-generation students face in academia, and how she is actively combating these thoughts and feelings. thenode.biologists.com/i-dont-belon...
thenode.biologists.com
I don’t belong here: Thoughts of a first-generation academic - the Node
As a university student working towards my bachelor’s degree, I didn’t even know what it would mean to add “Dr.” to my name. Six months into my postdoc, I
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DMM Journal @dmmjournal.bsky.social · 02/09/2026
Make sure you never miss DMM's latest articles and sign up for table of contents alerts journals.biologists.com/dmm/pages/al...
Don't miss the latest articles from Disease Models and Mechanisms. Sign up for table of contents alerts.
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Prof Anthony Isles @profantisles.bsky.social · 01/09/2026
📢NEW PAPER📢 Our paper is now published and fully #OA in @dmmjournal.bsky.social! Placental defects revealed by modelling Prader–Willi syndrome in mice journals.biologists.com/dmm/article/...
journals.biologists.com
Placental defects revealed by modelling Prader–Willi syndrome in mice
Editor's choice: Reduced expression of PWS-associated genes in the mouse placenta results in a 25% loss of the foetal endothelial cells that play a central role in nutrient and gas exchange.
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DMM Journal @dmmjournal.bsky.social · 01/09/2026
Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation Read and share the Research Article by Tamara González-Costa and colleagues @jldelapompa-cnic.bsky.social for free: doi.org/10.1242/dmm....
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DMM Journal @dmmjournal.bsky.social · 31/08/2026
We are pleased to be a media partner for EMBL Conference: Unlocking the functional diversity of gut microbiomes #EMBLGutMicrobeFunction Abstract submission: 15 Sep 2026 Registration (On-site): 27 Oct 2026 Registration (Virtual): 1 Dec 2026 bit.ly/4bpZ6Yr @embl.org @events.embl.org
bit.ly
Unlocking the functional diversity of gut microbiomes
EMBL Conference
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DMM Journal @dmmjournal.bsky.social · 29/08/2026
Kulkarni and colleagues uncover definitive evidence of age-dependent neuroinflammation as a key mechanism underlying amyotrophic lateral sclerosis-8. Check out the article: doi.org/10.1242/dmm....
Model for regulation of the glial immune response.
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