Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial ph...

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity against resistance mutations and reduced off-target toxicity.

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

In this Perspective, Levin and Wang give a brief history of bacterial growth rate and discuss how it is connected to nutrient availability and macromolecule synthesis, with a focus on (p)ppGpp as a ce...

The PLANT CYSTEINE OXIDASE (PCO) N-degron pathway contributes to oxygen sensing in plants. Here the authors identify HYPOXIA TRANSDUCER1 (HYT1) as a substrate of PCO and show it forms a coherent feed-...

Das et al. show that succinate regulates mitochondrial protein import through an interaction between Sfc1 (succinate-fumarate carrier) and the Tim23 translocase subunit. In the absence of succinate, Sfc1 associates with Tim23 and reduces protein import. Succinate promotes dissociation of the Sfc1-Tim23 complex, thereby enhancing TIM23 mediated protein translocation into mitochondria.

During an immune response, metabolism changes dramatically. Metabolites are oxidized to power immune cell functions, serve as building blocks for proliferation, and act as effectors to regulate pathog...

Marine sponges and ammonia-oxidizing archaea (AOA) represent one of the earliest animal-microbe symbioses. AOA are considered metabolically constrained chemolithoautotrophs that remove nitrogenous was...

Mitochondrial cristae are essential for respiration, yet the molecular basis of how the high curvature of these membrane folds is maintained remains unclear. Using structure prediction tools and multi...

The mitochondrial inner membrane complexes TIM23 and TIM22 mediate distinct protein topogenesis functions in polypeptide import. The authors reveal their mechanistic overlap in topogenic sequence reco...

Caliskan, Haas et al. present a cross-species subcellular proteomic atlas of pancreatic islets, revealing conserved organelle organization across human, pig, and mouse. The study uncovers disease-associated remodeling of vesicular trafficking, granule acidification machinery, and mitochondrial metabolism in a mouse model of type 2 diabetes.

Enzymatic metabolism emerged from metal-catalyzed, aqueous reactions of H2, CO2, NH3 and phosphite at a hydrothermal vent.

Alveolar rhabdomyosarcoma is an aggressive childhood cancer, and many children with this disease carry a mutation that combines two different proteins, PAX3 and FOXO1, into one protein, PAX3-FOXO1. Th...

Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...

Nature Structural & Molecular Biology, Published online: 19 August 2026; doi:10.1038/s41594-026-01860-1In this Review, the authors present the mechanisms at the interplay between ion transport and membrane fusion and fission in the endosomal system and beyond.

Abstract. Mitochondria are preferentially transmitted from the maternal plant in most angiosperms, including rice, and paternal mitochondria are generally

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Nature Metabolism - Academic careers are shaped by scientific discovery, professional networks, mentorship and the challenges of balancing research with personal and professional responsibilities....

The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...

An alkyne-tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the...

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By David Fay Choosing a lab in which to carry out your PhD is admittedly one of the more important decisions you’ll make in your early scientific career. But it’s important to have some perspective. F...

Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...

GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.

GOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...