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Stirling Churchman

@stirlingchurchman.bsky.social
1.9K followers 299 following 65 posts

Genetics professor at Harvard Medical School. Interested in RNA life cycles and genome organization across the cell, from the nucleus to mitochondria.

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Reposted by Stirling Churchman
Arnaud Krebs @arnaudkr.bsky.social · 14/09/2026
your starter pack for Single Molecule Genomics! Why you should do it (or not) - How you should do it. Collective effort with @vram142.bsky.social @stirlingchurchman.bsky.social @naltemose.bsky.social A Stergachis M Stadler W Greenleaf @embl.org rdcu.be/PmzSEV529GRa
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Stirling Churchman @stirlingchurchman.bsky.social · 07/08/2026
Happy 101 birthday to Jack Strominger! Celebrating at the farm!
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Reposted by Stirling Churchman
Lisa Hansen @lisanhansen.bsky.social · 29/07/2026
So excited to share my first preprint of grad school! Check out this thread to learn more about a cool new technique we are using to learn more about hidden layers of RNA regulation! Thank you so much to my coauthors, mentors, and lab for helping us get this story up!
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Stirling Churchman @stirlingchurchman.bsky.social · 28/07/2026
RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...
biorxiv.org
Analog intrinsic recoding measures RNA dynamics without chemical conversion
Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...
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Stirling Churchman @stirlingchurchman.bsky.social · 05/05/2026
1/ Preprint alert 🚨🚨🚨 How do cells decide where an mRNA should end? And how is that decision coordinated with splicing and transcription while the RNA is still being made? Here's what first author @hopem105.bsky.social found 👇
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Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · 02/04/2026
The 8th Epigenetics Meeting is coming — Dec 2–4, 2026, Max Planck Freiburg. 27 top speakers. Chromatin biology, epigenetic regulation, and real conversations. And you☝️!? Registration is open. Don't wait. 👇 🔗 events.ie-freiburg.mpg.de
Poster for the Max Planck Freiburg 8th Epigenetics Meeting from 2 to 4 December 2026 listing speakers, keynote, registration details, and contact information on a dark blue background with yellow and white text
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Stirling Churchman @stirlingchurchman.bsky.social · 13/02/2026
I watched Andy go from, "I was invited to OpenAI for a week, what should I get Chat to help me with?" to an exciting new result and preprint in under a month! I'm excited for Andy and the new speed at which physics can be done! openai.com/index/new-re...
openai.com
GPT-5.2 derives a new result in theoretical physics
A new preprint shows GPT-5.2 proposing a new formula for a gluon amplitude, later formally proved and verified by OpenAI and academic collaborators.
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Stirling Churchman @stirlingchurchman.bsky.social · 22/01/2026
Hope to see you at one of my favorite meetings! Deadline extended to tomorrow!!
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Stirling Churchman @stirlingchurchman.bsky.social · 08/01/2026
One day left till submit an Abstract!
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Reposted by Stirling Churchman
Alex Stark @alex-stark.bsky.social · 29/12/2025
Join @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
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Nature Biotechnology @natbiotech.nature.com · 03/12/2025
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
go.nature.com
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
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Martin Ott lab @mitolab.bsky.social · 03/12/2025
Our study on the molecular function of translational activators for mitochondrial protein synthesis is published: rdcu.be/eSWxT A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social Funded by @kawresearch.bsky.social
rdcu.be
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation
Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...
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Stirling Churchman @stirlingchurchman.bsky.social · 03/12/2025
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.
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Stirling Churchman @stirlingchurchman.bsky.social · 09/09/2025
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
biorxiv.org
HuD controls widespread RNA stability to drive neuronal activity-dependent responses
Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...
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Michela Palamin @mpalamin.bsky.social · 21/07/2025
First time posting here — and first-ever Single Molecule Conference 🧬 Held right at @embl.org Heidelberg, where I work! 4 days full of great science and great people. Fantastic meeting! 🔬 Curious to see where the single molecule field is going next! 👀 #EMBLSingleMolecule @events.embl.org
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Masa A. Shimazoe @masaashimazoe.bsky.social · 18/07/2025
Honored to receive 1st Place Poster Award 🏆 at the EMBL meeting "Gene Regulation: One Molecule at a Time"! Thank you to all who visited and engaged in exciting discussions. Grateful to the organizers for an excellent event! #EMBLSingleMolecule
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Arnaud Krebs @arnaudkr.bsky.social · 18/07/2025
#EMBLsinglemolecule was a blast! Happy to host the birth of single molecule genomics as a field and to think about the future with the microscopy crowd. Thanks to participants and organizers!
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Stirling Churchman @stirlingchurchman.bsky.social · 18/07/2025
The molecular feedback mechanisms that maintain yeast mito-nuclear balance represent elegant solutions to a major vulnerability in eukaryotic cells. I was privileged to be involved in this fascinating study!
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Martin Ott lab @mitolab.bsky.social · 18/07/2025
In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...
academic.oup.com
A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati
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EMBL Events @events.embl.org · 17/07/2025
🗨️💡Great conversations during well-attended lunch time panel discussions at #EMBLSingleMolecule Panel 1️⃣: Single molecule genomics data analysis Chair: @stirlingchurchman.bsky.social Panel 2️⃣: Single molecule microscopy data analysis Chairs: @laghalab.bsky.social, Dan Larson @arnaudkr.bsky.social
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Arnaud Krebs @arnaudkr.bsky.social · 17/07/2025
Absolutely thrilled of hosting the #EMBLSingleMolecule community together @embl.org for the first time under one roof! Exciting data and prospects!
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Reposted by Stirling Churchman
EMBL Events @events.embl.org · 15/07/2025
🍪 Taking a breather at 'Gene regulation: one molecule at a time' — where the science is complex, but the coffee is simple (and much needed!). From single-molecule insights to lively hallway conversations, it's clear: breakthroughs happen both in the lab and over lattes. ☕🧬 #EMBLSingleMolecule
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Eric Topol @erictopol.bsky.social · 17/07/2025
A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
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EMBL Events @events.embl.org · 15/07/2025
Welcome to the inaugural edition of 'Gene regulation: one molecule at a time' 🤩🧬 #EMBLSingleMolecule Most of the participants are already on site – now time for some science! Our Scientific Organisers: 🔹 @stirlingchurchman.bsky.social 🔹@arnaudkr.bsky.social 🔹 @laghalab.bsky.social 🔹 Daniel Larson
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Emadden @emadden.bsky.social · 18/06/2025
🧬 🧪The world’s on 🔥 BUT in the interest of sharing small wins, I am helping build something cool at EpiCypher that I'm proud of: Fiber-seq is an LRS assay that maps chromatin accessibility, DNAme, and DNA sequence on single molecules. If your jam is functional genomics/epigenetics, check this out.
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Life Science Alliance @lsajournal.org · 17/06/2025
Mitochondrial RNAs can be found in mitochondrial RNA granules (MRGs) where they are processed. However, here the authors show that during transcription arrest, mt-mRNAs form granules distinct from MRGs. @stirlingchurchman.bsky.social‬ www.life-science-alliance.org/content/8/9/...
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Katherine Xue @ksxue.bsky.social · 03/06/2025
Want to write to your community about the importance of science funding? Join me on zoom this Friday at 12pm ET / 9am PT to learn to write an op-ed as part of the #McClintockLetters initiative! Sign up to write a letter and register for the workshop here: blogs.cornell.edu/asap/events-...
A flyer with the heading McClintock Letter-Writing Workshop. Details are Friday, June 6th, 12pm ET and 9am PT, virtual.
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Harmit Singh Malik @harmitmalik.bsky.social · 30/05/2025
Make America Love Harvard Again
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Michael Baym @baym.lol · 24/05/2025
I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too
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Jeremy Berg @jeremymberg.bsky.social · 20/05/2025
REMINDER.....REMINDER......REMINDER 3 DAYS LEFT TO COMMENT ON SCHEDULE F 1/n
media.tenor.com
gumball and anais from the amazing world of gumball are sitting at a table
ALT: gumball and anais from the amazing world of gumball are sitting at a table
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Polly Fordyce @pollyfordyce.bsky.social · 05/05/2025
Our papers, device designs, and protocols are used by biotech companies every day. Basic science is not a luxury - federal funding drives the very earliest R&D that powers biotech and trains the next generation of scientists (3/3). #WithoutNSF
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Nature @nature.com · 29/04/2025
In 100 days in office, US President Donald Trump has destabilized eight decades of government support for science. This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention. Will US science survive Trump 2.0? www.nature.com/articles/d41...
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GenomeTDCC @genometdcc.org · 23/04/2025
📅 Genomic Technologies Open Science Day - June 9 FREE event featuring expert developers and users! Register: www.jax.org/scienceday25/ Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social 🧪🧬🖥️👩‍🔬 #STS Learn more at genometdcc.org#outreachevents
Free event with developers and users of genomic technologies.  Register at https://www.jax.org/scienceday25/
The objective of this forum is to provide post-secondary students, postdoctoral associates/fellows and biomedical researchers with a fundamental understanding of how these new technologies are utilized, as well as emerging opportunities and challenges associated with their optimization and use.
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Mounia Lagha @laghalab.bsky.social · 16/03/2025
Don’t forget to register for this special conference. If you like gene regulation from single molecule approaches, please join us #EMBLSingleMolecule. Imaging and Omics and a bit of theory for lots of fun!
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 22/04/2025
This is a pitch-perfect version of the argument we all need to be making. Thank you so much, Stirling and Jack.
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Barbara Mellone 🇺🇦 @centromellone.bsky.social · 21/04/2025
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Craig Kaplan @triggerloop.bsky.social · 21/04/2025
This is a much more important letter in WSJ than their recent Op-Ed from Hillsdale College. This is very important about what public funding of science means
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Stirling Churchman @stirlingchurchman.bsky.social · 21/04/2025
My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...
wsj.com
Opinion | Science Suffers With Trump’s Funding Freeze
America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.
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Minczuk Lab @mitogene.bsky.social · 12/04/2025
🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
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Ines Patop @inespatop.bsky.social · 11/04/2025
And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet
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Stirling Churchman @stirlingchurchman.bsky.social · 11/04/2025
Do your experiments involve direct RNA sequencing? Single molecule FISH or MS2/PP7 RNA labeling? SunTag imaging to study translation? Come to #EMBLSingleMolecule this summer to learn how single molecule data inform models of gene regulation! Modeling and data analysis will be discussed in depth!
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Arnaud Krebs @arnaudkr.bsky.social · 10/04/2025
Send us your abstract before easter! Extended deadline! we got lots of cool stories already! We would also welcome submissions with a focus on Translation and life of RNA!
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Sebastian Kadener @skadener.bsky.social · 09/04/2025
Super excited our paper on circRNA stability in the brain and their use as life experience markers is out! @inespatop.bsky.social www.cell.com/cell-reports...
cell.com
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators
Kirio et al. demonstrate that circRNAs steadily accumulate in the aging fly brain due to their exceptional stability. Temperature exposure (29°C) further elevates select circRNAs, which remain high weeks later, underscoring their potential as markers of both age and past experiences.
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Stirling Churchman @stirlingchurchman.bsky.social · 03/04/2025
Also interesting: Ask ChatGPT to draw what it imagines you look like. I'm wondering what other people get. Please share!
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EMBL Events @events.embl.org · 01/04/2025
🚨 Last chance to submit abstract for 'Gene regulation: one molecule at a time' 🧬✍🏼 👉🏼 s.embl.org/grg25-01-bl ℹ️ #EMBLSingleMolecule will catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 📅 Deadline: 8 April!
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WIRED @wired.com · 27/03/2025
Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.
wrd.cm
Inside arXiv—the Most Transformative Platform in All of Science
Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.
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Alex Knapp @thealexknapp.bsky.social · 13/03/2025
Researchers at MIT turned a skin cell into a neuron without having to go through that pesky intermediate stem cell step. Truly incredible. news.mit.edu/2025/mit-eng...
news.mit.edu
MIT engineers turn skin cells directly into neurons for cell therapy
MIT researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuri...
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Minczuk Lab @mitogene.bsky.social · 06/03/2025
REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch... Please re-post!
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Stirling Churchman @stirlingchurchman.bsky.social · 06/03/2025
In 1948, Jack Strominger wrote a report advocating for the formation of a National Science Foundation as a 23 year-old medical school student. He proposed we emerge from a world where our laboratories "depended on a flow of basic scientific facts from abroad". pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
A National Science Foundation
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