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Nick Stroustrup

@nstroustrup.bsky.social
1.3K followers 278 following 128 posts

A British/American group leader at @crg.eu . We study the biology of aging using molecular genetics, engineering, systems biology, and probabilistic machine learning. Lab page: lifespanmachine.crg.eu

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Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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Böke Lab @bokelab.bsky.social · 12/08/2026
What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...
nature.com
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature Aging
The spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou...
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Markus Höpfler @markushopfler.bsky.social · 08/05/2026
We're hiring! Join our growing team at the @crg.eu as a postdoc. Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation. Apply here: recruitment.crg.eu/content/jobs... Please share!
recruitment.crg.eu
Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab | CRG Online Recruitment Portal
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Nick Stroustrup @nstroustrup.bsky.social · 09/06/2026
wapo.st/43SQW6q
wapo.st
Pope Leo to bless new tower at Sagrada Família, Gaudí’s unfinished masterpiece
The basilica, designed by Antoni Gaudí, becomes the world's tallest church with the inauguration of its central spire — the 566-foot-high Tower of Jesus Christ.
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Nick Stroustrup @nstroustrup.bsky.social · 10/04/2026
How do wealthy parents help their offspring? By giving them ribosomes! Optimal ribosome provisioning is key to fast development in unpredictable environments. The fastest path to ribosomal wealth in nematodes is a maternal inheritance. Happy we could play a small part in this fascinating work.
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Lukas Röseler @aufdroeseler.bsky.social · 26/03/2026
-- New Open Research Game -- I reached the rank of Asst. Prof in #TenureRun! 🎓 I published 98 papers and paid $115.000 in APCs to publishers. My grant money is gone and I am exhausted. 💸 How far can you make it? Play now at forrt.org/TenureRun/
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Nick Stroustrup @nstroustrup.bsky.social · 02/03/2026
It's very sad to learn of David Botstein's passing. I worked in David's lab as an undergraduate--one of the most formative periods of my academic life and probably the biggest reason I work in biology today. I vividly remember my first meeting with David. I was a 3rd year engineering student,
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Nick Stroustrup @nstroustrup.bsky.social · 27/02/2026
Very cool!
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Javier Apfeld @javierapfeld.bsky.social · 28/01/2026
We found 24 neuron classes that are excited or inhibited by environmental H2O2, spread across the nose, mouth, and inner pharynx. Different neurons trigger at different H2O2 levels (from 1 µM early warning to >1 mM lethal), and many adapt, so responses encode dose + recent history. 7/
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Nick Stroustrup @nstroustrup.bsky.social · 18/02/2026
I was today years old when I discovered that "npj Aging" and "Nature Aging" are separate journals, despite being published with identical titles by Springer Nature!
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 17/02/2026
Please consider joining us--the new restrictions on academic freedom are coupled with a move to make all syllabi public and secretly record our classes--UNC's status as a top public university is at stake
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Nicole Gerlach @ngerlach.bsky.social · 12/02/2026
I knew about the downward part, but not the upward part, and now I'm not okay.
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EMBO @embo.org · 11/02/2026
Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award. Deadline: 15 May Read more: www.embo.org/the-embo-communities/f… #award
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Nick Stroustrup @nstroustrup.bsky.social · 05/02/2026
www.nytimes.com/2026/02/04/o...
nytimes.com
Opinion | I’m the Prime Minister of Spain. This Is Why the West Needs Migrants.
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Nick Stroustrup @nstroustrup.bsky.social · 02/02/2026
sunday afternoon family collaboration
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Monica Bettencourt-Dias @monicabettencourt.bsky.social · 23/01/2026
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
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Michael Baym @baym.lol · 01/01/2026
This was a lovely first read of 2026
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Alejandro Montenegro @aemonten.bsky.social · 27/12/2025
"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"
nature.com
Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis - Nature Communications
Determining the appropriate sample size (N) for bulk RNA sequencing experiments is critical to ensure reliable results. Here the authors perform an unusually large N experiment (N = 30 per group), ana...
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Carl T. Bergstrom @carlbergstrom.com · 15/12/2025
Yet one more reason we cannot allow LLMs to serve as epistemic grounding is that we cannot triangulate among them the way you can among reasonable independent sources. They bullshit in the same way and end up agreeing with one other about things that are completely false.
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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Nick Stroustrup @nstroustrup.bsky.social · 16/12/2025
What tools do we need to start engineering #aging and #longevity ? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
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Nick Stroustrup @nstroustrup.bsky.social · 08/12/2025
Multi-lingual children can end up with very random gaps in their vocab. I've asked my 4 y/o daughter every day after school *for years* what she ate for lunch. She would never tell me and I always wondered why. Today just before bedtime, we were talking and she asked me: baba, what is "lunch"?
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H. B. Beryl Rappaport @hbrappap.bsky.social · 25/11/2025
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵
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Casper Albers 🟥 @casperalbers.nl · 11/11/2025
Doing non-causal inference (and being explicit about it), yet using a causal word as second word in the title. If you pay Nature € 10.690, they will publish this in Nature Ageing. I can tell you what I think of that for free. www.nature.com/articles/s43...
screenshot from the paper, stating that no causal claims (like they did in the title) should be made.paper title
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EvoMG Program @evomg-bcn.bsky.social · 05/11/2025
Today we had a great EvoMG Seminar by Dario Valenzano @dvalenzano.bsky.social from FLI, who told us about some of their recent aging work using the fascinating short-lived killifish. Hosted by @mirimiam.bsky.social evomedgenomics.com/events/exter...
Dario Valenzano at PRBB
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Ricard Solé @ricardsole.bsky.social · 09/11/2025
What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level. www.biorxiv.org/content/10.1...
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Nick Stroustrup @nstroustrup.bsky.social · 08/11/2025
A detIled account of all the characters involved. www.nature.com/articles/d41...
nature.com
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
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Nick Stroustrup @nstroustrup.bsky.social · 06/11/2025
Come hear us talk about causality in biology, next Monday and Tuesday!
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Centre de Regulació Genòmica (CRG) @crg.eu · 23/10/2025
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...
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Nick Stroustrup @nstroustrup.bsky.social · 16/10/2025
theonion.com/biologists-a...
theonion.com
Biologists Announce There Absolutely Nothing We Can Learn From Clams
WOODS HOLE, MA—Saying they saw no conceivable reason to bother with the bivalve mollusks, biologists at the Woods Hole Oceanographic Institution announced Thursday that there was absolutely nothing to...
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Eric Turkheimer @ent3c.bsky.social · 13/10/2025
In 2018, Charles Murray challenged me to a bet: "We will understand IQ genetically—I think most of the picture will have been filled in by 2025—there will still be blanks—but we’ll know basically what’s going on." It's now 2025, and I claim a win. I write about it in The Atlantic.
theatlantic.com
Your Genes Are Simply Not Enough to Explain How Smart You Are
Seven years ago, I took a bet with Charles Murray about whether we’d basically understand the genetics of intelligence by now.
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Jeremy Berg @jeremymberg.bsky.social · 10/10/2025
A response from MIT rejecting "The Compact"... orgchart.mit.edu/letters/rega...
orgchart.mit.edu
Regarding the Compact | MIT Organization Chart
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Nick Stroustrup @nstroustrup.bsky.social · 05/10/2025
moonbow last night over our neighborhood
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Nick Stroustrup @nstroustrup.bsky.social · 02/10/2025
www.fbbva.es/noticias/adj...
fbbva.es
Seleccionados 12 proyectos de investigación acerca de cuestiones centrales en tres grandes áreas de conocimiento, en el marco del Programa Fundamentos Fundación BBVA - Fundación BBVA
FÍSICA, QUÍMICA Proyectos seleccionados: “Reticular enzyme-like catalysis” (RETICAT) Investigadores principales: Miquel Costas Salgueiro (Universitat de Girona) y Daniel Maspoch Comamala (Institut Cat...
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Nick Stroustrup @nstroustrup.bsky.social · 02/10/2025
Thrilled to hear that our BBVA fundamentos grant was funded. Thanks to @bbvaenespana.bsky.social for their support of new causal methods in aging. With only 4 of these awarded each year in the life sciences, a special congrats to our post-doc Jeremy Vicencio for teaming up to make it happen!
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Nick Stroustrup @nstroustrup.bsky.social · 25/09/2025
There's some super interesting nemography going on these days!
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Jeremy Berg @jeremymberg.bsky.social · 22/09/2025
All my emails to Director Bhattacharya now available... jeremymberg.github.io/jeremyberg.g...
Cover of "Fifty Shades of 'Jay'" with emails from Jeremy M. Berg to NIH Director Jayanta Bhattacharya.
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Hank Greely @hankgreely.bsky.social · 20/09/2025
OH NO! "The White House issued a proclamation today, Sept. 19, 2025, around 4:36 PM PDT imposing a $100,000 fee for each H-1B visa holder who enters the U.S. after Sept. 21, 2025, 12:01 AM EDT. In CA, this will take effect tomorrow, Sept. 20, 2025, at 9:01 PM PDT." Emergency notice at Stanford.
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Nick Stroustrup @nstroustrup.bsky.social · 09/09/2025
Ups!
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James McInerney @jomcinerney.bsky.social · 07/09/2025
Extraordinary paper. I LOVE this sentence: “This translates to a net lateral gene transfer rate of ~250 genes L−1 seawater day−1 and involves both “flexible” and “core” genes. “ Must read in detail, but these numbers are amazing. academic.oup.com/ismej/advanc...
academic.oup.com
Net rate of lateral gene transfer in marine prokaryoplankton
Abstract. Lateral gene transfer is a major evolutionary process in Bacteria and Archaea. Despite its importance, lateral gene transfer quantification in na
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Nick Stroustrup @nstroustrup.bsky.social · 07/09/2025
Será posible vivir 150 años como dicen Putin y Xi Jinping? www.lavanguardia.com/ciencia/2025...
lavanguardia.com
¿Será posible vivir 150 años como dicen Putin y Xi Jinping?
“Con los desarrollos de la biotecnología, se pueden trasplantar continuamente órganos humanos y las personas pueden vivir más y más jóvenes, e incluso alcanzar la
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Maarten van Smeden @maartenvsmeden.bsky.social · 12/08/2025
If you think AI is cool, wait until you learn about regression analysis
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Brett "Solidarity 2026" Banditelli @banditelli.org · 10/08/2025
DOUBLE PELICAN DIVE AFTER SUNSET!!!! wooooo! What a way to end the week! time to sleep and prepare for the horrors and joys of the next one 🪶
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Simon Fisher @profsimonfisher.bsky.social · 07/08/2025
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
cell.com
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.
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Waggoner Lab @labwaggoner.bsky.social · 01/08/2025
‘Congress has your back’: US senators tell scientists they want to protect NIH budget www.nature.com/articles/d41...
nature.com
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.
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Brian Tyler Cohen @briantylercohen.bsky.social · 01/08/2025
And here I was thinking the way to solve hunger was food.
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Frank Harrell @f2harrell.bsky.social · 24/07/2025
New blog article on Statistical Thinking: confidence limits for bootstrap overfitting-corrected predictive performance measures for regression models, useful for strong internal validations including confidence bands for debiased calibration curves: fharrell.com/post/bootcal #statistics #StatsSky
fharrell.com
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Manuel Irimia @mirimiam.bsky.social · 23/07/2025
🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇
upf.edu
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The EMBO Journal @embojournal.org · 16/07/2025
The proteostatic landscape of healthy human oocytes Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse www.embopress.org/doi/full/10....
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