Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22 620983
Reposted by Nick StroustrupBöke Lab @bokelab.bsky.social · 12/08/2026What does an ovary actually look like as it ages—one oocyte at a time? We mapped >85,000 oocytes in >100 intact mouse ovaries, in 3D, across the reproductive lifespan. And the ovary turned out to be much more organized than we expected. 🧵 1/5 www.nature.com/articles/s43...nature.comThree-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve - Nature AgingThe spatiotemporal dynamics of the depletion of the ovarian reserve remain incompletely understood. Combining whole-ovary imaging, AI and modeling, the authors mapped over 85,000 mouse oocytes and fou... 14816
Reposted by Nick StroustrupMarkus Höpfler @markushopfler.bsky.social · 08/05/2026We're hiring! Join our growing team at the @crg.eu as a postdoc. Curious about how mRNA translation and decay cross-talk? We're looking for a postdoctoral researcher to lead a project in the field of RNA biology and gene regulation. Apply here: recruitment.crg.eu/content/jobs... Please share!recruitment.crg.euPostdoc in the Dynamics of Protein Synthesis and RNA Decay Lab | CRG Online Recruitment Portal 0108
Nick Stroustrup @nstroustrup.bsky.social · 09/06/2026wapo.st/43SQW6qwapo.stPope Leo to bless new tower at Sagrada Família, Gaudí’s unfinished masterpieceThe basilica, designed by Antoni Gaudí, becomes the world's tallest church with the inauguration of its central spire — the 566-foot-high Tower of Jesus Christ. 083
Nick Stroustrup @nstroustrup.bsky.social · 10/04/2026How do wealthy parents help their offspring? By giving them ribosomes! Optimal ribosome provisioning is key to fast development in unpredictable environments. The fastest path to ribosomal wealth in nematodes is a maternal inheritance. Happy we could play a small part in this fascinating work. 031
Reposted by Nick StroustrupLukas Röseler @aufdroeseler.bsky.social · 26/03/2026-- New Open Research Game -- I reached the rank of Asst. Prof in #TenureRun! 🎓 I published 98 papers and paid $115.000 in APCs to publishers. My grant money is gone and I am exhausted. 💸 How far can you make it? Play now at forrt.org/TenureRun/ 15720
Nick Stroustrup @nstroustrup.bsky.social · 02/03/2026It's very sad to learn of David Botstein's passing. I worked in David's lab as an undergraduate--one of the most formative periods of my academic life and probably the biggest reason I work in biology today. I vividly remember my first meeting with David. I was a 3rd year engineering student, 120
Reposted by Nick StroustrupJavier Apfeld @javierapfeld.bsky.social · 28/01/2026We found 24 neuron classes that are excited or inhibited by environmental H2O2, spread across the nose, mouth, and inner pharynx. Different neurons trigger at different H2O2 levels (from 1 µM early warning to >1 mM lethal), and many adapt, so responses encode dose + recent history. 7/ 111
Nick Stroustrup @nstroustrup.bsky.social · 18/02/2026I was today years old when I discovered that "npj Aging" and "Nature Aging" are separate journals, despite being published with identical titles by Springer Nature! 020
Reposted by Nick StroustrupMark Peifer (He, him) @peiferlabunc.bsky.social · 17/02/2026Please consider joining us--the new restrictions on academic freedom are coupled with a move to make all syllabi public and secretly record our classes--UNC's status as a top public university is at stake 0104
Reposted by Nick StroustrupNicole Gerlach @ngerlach.bsky.social · 12/02/2026I knew about the downward part, but not the upward part, and now I'm not okay. 2174
Reposted by Nick StroustrupEMBO @embo.org · 11/02/2026Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award. Deadline: 15 May Read more: www.embo.org/the-embo-communities/f… #award 07038
Nick Stroustrup @nstroustrup.bsky.social · 05/02/2026www.nytimes.com/2026/02/04/o...nytimes.comOpinion | I’m the Prime Minister of Spain. This Is Why the West Needs Migrants. 031
Reposted by Nick StroustrupMonica Bettencourt-Dias @monicabettencourt.bsky.social · 23/01/2026📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs... 29194
Reposted by Nick StroustrupMichael Baym @baym.lol · 01/01/2026This was a lovely first read of 2026 0226
Reposted by Nick StroustrupAlejandro Montenegro @aemonten.bsky.social · 27/12/2025"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"nature.comOptimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis - Nature CommunicationsDetermining the appropriate sample size (N) for bulk RNA sequencing experiments is critical to ensure reliable results. Here the authors perform an unusually large N experiment (N = 30 per group), ana... 03114
Reposted by Nick StroustrupCarl T. Bergstrom @carlbergstrom.com · 15/12/2025Yet one more reason we cannot allow LLMs to serve as epistemic grounding is that we cannot triangulate among them the way you can among reasonable independent sources. They bullshit in the same way and end up agreeing with one other about things that are completely false. 837988
Reposted by Nick StroustrupYamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n 29546230
Nick Stroustrup @nstroustrup.bsky.social · 16/12/2025What tools do we need to start engineering #aging and #longevity ? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10 32210
Nick Stroustrup @nstroustrup.bsky.social · 08/12/2025Multi-lingual children can end up with very random gaps in their vocab. I've asked my 4 y/o daughter every day after school *for years* what she ate for lunch. She would never tell me and I always wondered why. Today just before bedtime, we were talking and she asked me: baba, what is "lunch"? 060
Reposted by Nick StroustrupH. B. Beryl Rappaport @hbrappap.bsky.social · 25/11/2025So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵 16507166
Reposted by Nick StroustrupCasper Albers 🟥 @casperalbers.nl · 11/11/2025Doing non-causal inference (and being explicit about it), yet using a causal word as second word in the title. If you pay Nature € 10.690, they will publish this in Nature Ageing. I can tell you what I think of that for free. www.nature.com/articles/s43... 714440
Reposted by Nick StroustrupEvoMG Program @evomg-bcn.bsky.social · 05/11/2025Today we had a great EvoMG Seminar by Dario Valenzano @dvalenzano.bsky.social from FLI, who told us about some of their recent aging work using the fascinating short-lived killifish. Hosted by @mirimiam.bsky.social evomedgenomics.com/events/exter... 0115
Reposted by Nick StroustrupRicard Solé @ricardsole.bsky.social · 09/11/2025What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level. www.biorxiv.org/content/10.1... 04414
Nick Stroustrup @nstroustrup.bsky.social · 08/11/2025A detIled account of all the characters involved. www.nature.com/articles/d41...nature.comWhat Rosalind Franklin truly contributed to the discovery of DNA’s structureFranklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player. 041
Nick Stroustrup @nstroustrup.bsky.social · 06/11/2025Come hear us talk about causality in biology, next Monday and Tuesday! 030
Reposted by Nick StroustrupCentre de Regulació Genòmica (CRG) @crg.eu · 23/10/2025Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t... 12528
Nick Stroustrup @nstroustrup.bsky.social · 16/10/2025theonion.com/biologists-a...theonion.comBiologists Announce There Absolutely Nothing We Can Learn From ClamsWOODS HOLE, MA—Saying they saw no conceivable reason to bother with the bivalve mollusks, biologists at the Woods Hole Oceanographic Institution announced Thursday that there was absolutely nothing to... 120
Reposted by Nick StroustrupEric Turkheimer @ent3c.bsky.social · 13/10/2025In 2018, Charles Murray challenged me to a bet: "We will understand IQ genetically—I think most of the picture will have been filled in by 2025—there will still be blanks—but we’ll know basically what’s going on." It's now 2025, and I claim a win. I write about it in The Atlantic.theatlantic.comYour Genes Are Simply Not Enough to Explain How Smart You AreSeven years ago, I took a bet with Charles Murray about whether we’d basically understand the genetics of intelligence by now. 10346124
Reposted by Nick StroustrupJeremy Berg @jeremymberg.bsky.social · 10/10/2025A response from MIT rejecting "The Compact"... orgchart.mit.edu/letters/rega...orgchart.mit.eduRegarding the Compact | MIT Organization Chart 210017
Nick Stroustrup @nstroustrup.bsky.social · 02/10/2025www.fbbva.es/noticias/adj...fbbva.esSeleccionados 12 proyectos de investigación acerca de cuestiones centrales en tres grandes áreas de conocimiento, en el marco del Programa Fundamentos Fundación BBVA - Fundación BBVAFÍSICA, QUÍMICA Proyectos seleccionados: “Reticular enzyme-like catalysis” (RETICAT) Investigadores principales: Miquel Costas Salgueiro (Universitat de Girona) y Daniel Maspoch Comamala (Institut Cat... 010
Nick Stroustrup @nstroustrup.bsky.social · 02/10/2025Thrilled to hear that our BBVA fundamentos grant was funded. Thanks to @bbvaenespana.bsky.social for their support of new causal methods in aging. With only 4 of these awarded each year in the life sciences, a special congrats to our post-doc Jeremy Vicencio for teaming up to make it happen! 2101
Nick Stroustrup @nstroustrup.bsky.social · 25/09/2025There's some super interesting nemography going on these days! 031
Reposted by Nick StroustrupJeremy Berg @jeremymberg.bsky.social · 22/09/2025All my emails to Director Bhattacharya now available... jeremymberg.github.io/jeremyberg.g... 1218553
Reposted by Nick StroustrupHank Greely @hankgreely.bsky.social · 20/09/2025OH NO! "The White House issued a proclamation today, Sept. 19, 2025, around 4:36 PM PDT imposing a $100,000 fee for each H-1B visa holder who enters the U.S. after Sept. 21, 2025, 12:01 AM EDT. In CA, this will take effect tomorrow, Sept. 20, 2025, at 9:01 PM PDT." Emergency notice at Stanford. 166
Reposted by Nick StroustrupJames McInerney @jomcinerney.bsky.social · 07/09/2025Extraordinary paper. I LOVE this sentence: “This translates to a net lateral gene transfer rate of ~250 genes L−1 seawater day−1 and involves both “flexible” and “core” genes. “ Must read in detail, but these numbers are amazing. academic.oup.com/ismej/advanc...academic.oup.comNet rate of lateral gene transfer in marine prokaryoplanktonAbstract. Lateral gene transfer is a major evolutionary process in Bacteria and Archaea. Despite its importance, lateral gene transfer quantification in na 0133
Nick Stroustrup @nstroustrup.bsky.social · 07/09/2025Será posible vivir 150 años como dicen Putin y Xi Jinping? www.lavanguardia.com/ciencia/2025...lavanguardia.com¿Será posible vivir 150 años como dicen Putin y Xi Jinping?“Con los desarrollos de la biotecnología, se pueden trasplantar continuamente órganos humanos y las personas pueden vivir más y más jóvenes, e incluso alcanzar la 052
Reposted by Nick StroustrupMaarten van Smeden @maartenvsmeden.bsky.social · 12/08/2025If you think AI is cool, wait until you learn about regression analysis 512521
Reposted by Nick StroustrupBrett "Solidarity 2026" Banditelli @banditelli.org · 10/08/2025DOUBLE PELICAN DIVE AFTER SUNSET!!!! wooooo! What a way to end the week! time to sleep and prepare for the horrors and joys of the next one 🪶 832393293
Reposted by Nick StroustrupSimon Fisher @profsimonfisher.bsky.social · 07/08/2025If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇cell.comNotes from Beethoven’s genomeWesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement. 720494
Reposted by Nick StroustrupWaggoner Lab @labwaggoner.bsky.social · 01/08/2025‘Congress has your back’: US senators tell scientists they want to protect NIH budget www.nature.com/articles/d41...nature.com‘Congress has your back’: US senators tell scientists they want to protect NIH budgetSenate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law. 37929
Reposted by Nick StroustrupBrian Tyler Cohen @briantylercohen.bsky.social · 01/08/2025And here I was thinking the way to solve hunger was food. 1984224664276
Reposted by Nick StroustrupFrank Harrell @f2harrell.bsky.social · 24/07/2025New blog article on Statistical Thinking: confidence limits for bootstrap overfitting-corrected predictive performance measures for regression models, useful for strong internal validations including confidence bands for debiased calibration curves: fharrell.com/post/bootcal #statistics #StatsSkyfharrell.com 2268
Reposted by Nick StroustrupManuel Irimia @mirimiam.bsky.social · 23/07/2025🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇upf.edu 14865
Reposted by Nick StroustrupThe EMBO Journal @embojournal.org · 16/07/2025The proteostatic landscape of healthy human oocytes Elvan Böke and colleagues @bokelab.bsky.social find that mature human oocytes show reduced activity of lysosomes, proteasomes and mitochondria, highlighting reproductive differences between humans and mouse www.embopress.org/doi/full/10.... 2102