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William Garland

@willgarland.bsky.social
445 followers 438 following 34 posts

RNA decay, RNA sorting, transcriptional regulation Aarhus University, Denmark 🇩🇰

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William Garland @willgarland.bsky.social · 29/09/2026
New from the lab! We uncover how the cap-binding complex promotes first-intron splicing: ZC3H18 recruits splicing factors while competing with the RNA-decay machinery, linking two alternative fates for newly made RNA. doi.org/10.1016/j.mo...
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Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026
Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n
science.org
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
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Peter Andersen @germline.bsky.social · 08/09/2026
We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks
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Virginia Busetto @virginiabusetto.bsky.social · 08/09/2026
Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6...
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William Garland @willgarland.bsky.social · 14/08/2026
Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...
au.dk
Postdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet
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Andrii Bugai @abugai.bsky.social · 17/06/2026
Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...
nature.com
Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
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Ana Gázquez-Gutiérrez @anagazquezg.bsky.social · 05/03/2026
I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR
academic.oup.com
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev
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William Garland @willgarland.bsky.social · 06/02/2026
Pleased to be a small part of this collaboration with the @labconti.bsky.social now published at @narjournal.bsky.social. Here we combine structure prediction, biochem, cryo-EM, and IP-based approaches to explore connections between RNA quality control to transcription termination complexes.
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Plaschka lab @plaschkalab.bsky.social · 21/11/2025
Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
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Ulrich Hohmann @hohmannulrich.bsky.social · 12/10/2025
Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
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William Garland @willgarland.bsky.social · 17/09/2025
How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...
biorxiv.org
Molecular basis of polyadenylated RNA fate determination in the nucleus
Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...
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William Garland @willgarland.bsky.social · 10/09/2025
Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus! Deadline is October 1st danish-rna-society.nemtilmeld.dk/8/
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William Garland @willgarland.bsky.social · 22/07/2025
Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰 Please share around 🤝
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William Garland @willgarland.bsky.social · 03/07/2025
Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex Article: rdcu.be/euC4U News & Views: rdcu.be/euC5l
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Torben Heick Jensen @heick.bsky.social · 27/06/2025
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...
mbg.au.dk
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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William Garland @willgarland.bsky.social · 19/06/2025
We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social. Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
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William Garland @willgarland.bsky.social · 17/06/2025
mbg.au.dk/en/news-and-...
mbg.au.dk
International recognition for Aarhus researchers: RNA science takes off
RNA research in Aarhus is taking a significant leap forward. Two researchers from the same department and research environment have both just been awarded one of Europe’s most prestigious research gra...
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William Garland @willgarland.bsky.social · 02/06/2025
Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8
The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...
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William Garland @willgarland.bsky.social · 28/04/2025
I've been wanting to try something like this. Awesome to see that it works 👍
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albinsan.bsky.social @albinsan.bsky.social · 07/04/2025
Very proud to share this work just out in NAR: spearheaded by @jamieauxillos.bsky.social and Arnauld Stigliani: TLDR-seq, a method for 5’ to 3’ end long-read sequencing of capped RNAs regardless of 3’ end polyadenylation, based on the @nanoporetech.com platform. (1/4) tinyurl.com/3c2ksdmr
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Torben Heick Jensen @heick.bsky.social · 20/02/2025
PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
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AlphaFold Unofficial @alphafold.bsky.social · 20/02/2025
“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. AI co-scientist is a collaborative tool to help experts gather research and refine their work” blog.google/feed/google-...
blog.google
We’re launching a new AI system for scientists.
Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. Researchers…
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Leopold Parts @leopoldparts.bsky.social · 31/01/2025
We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church. www.science.org/doi/10.1126/...
science.org
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
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William Garland @willgarland.bsky.social · 07/02/2025
New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology @molbiolau.bsky.social mbg.au.dk/en/news-and-...
mbg.au.dk
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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RNA Society @rnasociety.bsky.social · 04/02/2025
We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open! www2.rnasociety.org This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.
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Cell Press @cellpress.bsky.social · 31/01/2025
Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more. To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲 go.bsky.app/TdKYuS7
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William Garland @willgarland.bsky.social · 21/01/2025
Resident colour blind member of the lab here 🙋‍♂️ Please make your figures friendly to us.
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 10/01/2025
Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci www.biorxiv.org/content/10.1101/202…
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William Garland @willgarland.bsky.social · 07/01/2025
Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells. I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
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MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 29/12/2024
40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.
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William Garland @willgarland.bsky.social · 21/12/2024
Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️ Back in Derbyshire and busy making sausage rolls. It's been a productive year, but i'm in dire need of a break.
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William Garland @willgarland.bsky.social · 13/12/2024
📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs.
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Gav Armstrong @nchemgav.bsky.social · 10/12/2024
Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...
nature.com
Colour me better: fixing figures for colour blindness
Images can be made more accessible by choosing hues, shapes and textures carefully.
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William Garland @willgarland.bsky.social · 29/11/2024
New preprint! Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export. www.biorxiv.org/content/10.1...
biorxiv.org
Structural basis for the synergistic assembly of the snRNA export complex
The nuclear cap-binding complex (CBC) and its partner ARS2 play crucial roles in regulating Pol II transcript fate through mutually exclusive interactions with RNA effectors. One such effector, PHAX, ...
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Anita Corbett @acorbe2.bsky.social · 19/11/2024
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
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Jess Kelley @jesskelley.bsky.social · 26/11/2024
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
cell.com
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...
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William Garland @willgarland.bsky.social · 25/11/2024
go.bsky.app/RN6HnZp
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John F. Cryan @jfcryan.bsky.social · 20/11/2024
Like ‘old Twitter’: The scientific community finds a new home on Bluesky www.science.org/content/arti...
science.org
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
After recent changes to Elon Musk’s X, a gradual migration turns into a stampede
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William Garland @willgarland.bsky.social · 08/11/2024
Latest from the lab, finally out in Molecular Cell. Here we show a physical and functional link between the Microprocessor and a variant NEXT complex. Together, these complexes degrade the 5' flanks of pre-miRNAs and other stem-loop-containing RNAs. doi.org/10.1016/j.mo...
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William Garland @willgarland.bsky.social · 08/11/2024
This is more of a reminder to myself to keep checking this.
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William Garland @willgarland.bsky.social · 12/07/2024
We put together a Molecular Cell preview for the latest papers from Wojtek Galej and Stefanie Jonas uncovering fascinating new details about the Integrator complex. Preview here: t.co/XGMwJwBOZa Articles here: t.co/9lx1z3bvE6 t.co/k0EqO54gXB
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William Garland @willgarland.bsky.social · 02/06/2024
Representing MBG🇩🇰 at #RNA24 We actually got some sun out of Edinburgh
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William Garland @willgarland.bsky.social · 02/06/2024
Lovely bonus from #RNA24 was winning a (very generous) poster prize ✌️
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/06/2024
DNA-directed termination of mammalian RNA polymerase II www.biorxiv.org/content/10.1101/202…
biorxiv.org
DNA-directed termination of mammalian RNA polymerase II https://www.biorxiv.org/content/10.1101/2024.06.01.596947v1
The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination invo
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William Garland @willgarland.bsky.social · 26/03/2024
Do you want to make high quality, customisable genome browser figures? Check out the lab's new STAR Protocol paper doi.org/10.1016/j.xp...
doi.org
Redirecting
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William Garland @willgarland.bsky.social · 12/02/2024
New preprint! How does PP2A-B55 recognise its substrates? Great to be a part of this project. www.biorxiv.org/content/10.1...
biorxiv.org
Substrate recognition principles for PP2A-B55
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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William Garland @willgarland.bsky.social · 08/02/2024
Following on from HUSH2, there are now ChAHP and ChAHP2 complexes www.biorxiv.org/content/10.1...
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Toby Baril @tobybarilbio.bsky.social · 25/01/2024
Great to join this Bluesky community. For anyone interested in Transposable Elements, there is now a curated feed to all things TEsky, called TEworldwide: bsky.app/profile/did:... Include TEsky and/or TEworldwide in your posts to be featured!
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William Garland @willgarland.bsky.social · 15/01/2024
Nice HUSH review from the Helin group. www.nature.com/articles/s41...
nature.com
Keep quiet: the HUSH complex in transcriptional silencing and disease - Nature Structural & Molecula...
Here, the authors discuss the various roles of the HUSH transcriptional silencing complex and its dysregulation in disease.
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 12/01/2024
A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci www.biorxiv.org/content/10.1101/202…
biorxiv.org
A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci https://www.biorxiv.org/content/10.1101/2024.01.11.575256v1
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting
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