Miklas et al. characterize age-related C. elegans intestinal secretory-pathway proteins using proximity labeling tools and in vivo proteomics. They identify a conserved secreted phosphatase, ACP7, that extends lifespan in a secretion- and phosphatase-dependent manner. This resource highlights the role of extracellular enzymes in regulating lifespan.

Discover how epigenetics and transcription shape aging and disease, with new tools, therapies, and collaborations at this leading conference.

Nature Communications - The authors use a Caenorhabditis elegans model of Verheij syndrome, caused by mutations in the splicing factor PUF60, and show that Vitamin B12 can rescue the phenotype.

Nature - Somatic mutations reveal the ontogeny of microglia in human aging

Podcast Episode · It Turns Out · July 24 · 39m

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

During embryogenesis, cell types arise in a predictable order because developmental regulators act sequentially. But how evolutionary changes in morphogenesis reshape the signaling environments that a...

In the 1960s, worm-training experiments and their strange implications captivated the nation. Columnist Claire L. Evans follows the neuroscientists who attempted to recapture the magic.

Stanford University is seeking a Life Science Research Professional 1 to study the mechanisms of aging and rejuvenation, particularly in a variety of....

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Weinreb et al. reveal a hierarchy of timescales in mouse behavior, including low-level syllables and high-level behavioral states. States and syllables are encoded in different brain areas. Prefrontal...

To investigate the link between the gut microbiome and ovarian health, here the authors transplant gut microbiota from estropausal female mice to young adult female mice. Microbial transplantation imp...

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....

YouTube video by The Dissenter

Single-nucleus sequencing, specifically, remains the gold standard for characterizing difficult-to-dissociate cell types, such as neurons in complex b…

Parenting behavior emerges from hormonally sensitive circuits, but how distinct circuit components are affected by, and contribute to, sex and state dependent changes in infant caregiving remains uncl...

The adult brain consists of billions of neurons that show an unimaginable complexity in their structural diversity and functional connectivity allowing for a plethora of brain functions. Notably…

Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.