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Nick Riley

@nmriley.bsky.social
1.3K followers 622 following 178 posts

Assistant Professor, University of Washington, Dept. of Chemistry. PI of the Riley Research Group, @riley-research.bsky.social. Glyco, mass spec, chembio. Sports, food, travel, dogs. riley-research.com

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Nick Riley @nmriley.bsky.social · 28/08/2026
Glycoproteoforms are the unit of biological information in the glycoproteome, but measuring intact glycoproteins to capture combinatorial modification states remains a huge #glycotime challenge. @timveth.bsky.social tackled this issue head on in the latest preprint from @riley-research.bsky.social
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Lucy Dornan @lucygdornan.bsky.social · 26/06/2026
Leaving Blackburn after a really wonderful week discussing all things Golgi and glycobiology! So many new things learned and ideas to be explored - it’s an excellent time to have a thesis discussion to write..!
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Iain Wilson @iainwilsonwien.bsky.social · 25/06/2026
Nick Riley @nmriley.bsky.social is just starting his @biochemsoc.bsky.social Early Career Research Award Lecture during the 95th Harden Conference! #glycotime #TeamMassSpec
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Jay Forsythe @jaygforsythe.bsky.social · 19/06/2026
“The project of freedom, Juneteenth reminds us, is precarious, and we should regularly remind ourselves how many people who came before us never got to experience it, and how many people there are still waiting.” - Clint Smith, How the Word Is Passed
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Christopher Rose @cmichaelrose.bsky.social · 03/06/2026
Writing from the airport. Sad to miss it, but out preprint just dropped in time! Have a great discussion tonight! www.biorxiv.org/content/10.6...
biorxiv.org
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Nick Riley @nmriley.bsky.social · 02/06/2026
If you are looking for a Tuesday evening #ASMS2026 workshop to attend, consider joining us for fun discussions about real time mass spectrometry.
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Riley Research Group @riley-research.bsky.social · 01/06/2026
The Riley Research Group is excited to be at #ASMS2026. There will be a lot of cool science this week, and we hope to add to the conversation with presentations from our group!
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Mark McIntyre @markjmcintyre.bsky.social · 03/04/2026
I don't remember seeing an image of Earth before that captures the (thin, fragile, tiny layer of) atmosphere so clearly. I mean, look at that.
Zooming in on the photo of Earth taken by astronauts on Artemis II on their way to the Moon, you can clearly see the Aurora Borealis and thin layer of atmosphere wrapping around the planet.Zooming in on the photo of Earth taken by astronauts on Artemis II, you can clearly see the thin layer of atmosphere wrapping around the entire planet.
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Devin Schweppe @dschweppe.bsky.social · 07/04/2026
The next iteration of O-MAP targeting genomic loci is now at eLife!! DNA O-MAP enables proximity labeling at specific DNA loci took a ton of work from many lab members and collaborators, so it's really exciting to wrap up this paper with @oligopain.bsky.social! elifesciences.org/articles/102...
elifesciences.org
DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci
DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modifica...
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B. Erin Cole @berincole.bsky.social · 07/04/2026
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Nick Riley @nmriley.bsky.social · 02/04/2026
It is very cool to see this piece from a former student of mine, @mnicolen.bsky.social, in Nature's Career Feature section: www.nature.com/articles/d41...
nature.com
My PhD student is stuck. How do I teach them perseverance and problem solving?
A new principal investigator wants to help PhD students to develop resilience and creativity in the laboratory without hovering or doing the work for them.
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Nick Riley @nmriley.bsky.social · 27/03/2026
A big congratulations to the 2026 I. M. Kolthoff Award Winners! acsanalytical.org/2026/03/12/2... This @acs.org award for undergraduate researchers supported 4 outstanding students (Damon Chan, Alex Szczepankiewicz, Katelyn Barnes, & Zane Alsebai) attending @pittcon.bsky.social and #ACSspring 2026
acsanalytical.org
2026 I. M. Kolthoff Award Winners
The I.M. Kolthoff Award is given annually to deserving undergraduates who have done undergraduate research in the field of analytical chemistry, broadly defined, in celebration of the life and accompl...
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Nick Riley @nmriley.bsky.social · 30/03/2026
Check out the newest entry in the ACS Div. of Analytical Chem. Education Committee's "Meet an Analytical Chemist" initiative. This quarter we highlight Dr. Christina Jones, Partnerships and Outreach Strategist at NIST: acsanalytical.org/2026/02/26/m...
acsanalytical.org
Meet an Analytical Chemist – February 2026
Christina Jones, Ph.D.National Institute of Standards and Technology, Office of Advanced Manufacturing, Partnerships and Outreach Strategist How did you get started in the field of Analytical Chemistr...
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Nick Riley @nmriley.bsky.social · 27/03/2026
A big congratulations to the 2026 I. M. Kolthoff Award Winners! acsanalytical.org/2026/03/12/2... This @acs.org award for undergraduate researchers supported 4 outstanding students (Damon Chan, Alex Szczepankiewicz, Katelyn Barnes, & Zane Alsebai) attending @pittcon.bsky.social and #ACSspring 2026
acsanalytical.org
2026 I. M. Kolthoff Award Winners
The I.M. Kolthoff Award is given annually to deserving undergraduates who have done undergraduate research in the field of analytical chemistry, broadly defined, in celebration of the life and accompl...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 26/03/2026
Fantastic new resource for glycoproteomics from @nmriley.bsky.social and coworkers #glycotime
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Nick Riley @nmriley.bsky.social · 26/03/2026
As always, we appreciate authors like Rebeca and Morten (and many in our field) who make raw data publicly available. Data sharing streamlines #glycotime tool building and helps us advance together as a field.
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bioRxivpreprint @biorxivpreprint.bsky.social · 25/03/2026
Mucin-binding protein shuttles enable delivery of brain-targeted therapeutics www.biorxiv.org/content/10.64898/20…
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Nick Riley @nmriley.bsky.social · 25/03/2026
The complexity of glycoproteomics data creates a bottleneck in data interpretation and communication. We (@timveth.bsky.social, @riley-research.bsky.social) built GlycoDiveR as a step toward bridging gaps between search-engine output and biological interpretation through #glycotime visualizations.
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PastelBio @pastelbio.bsky.social · 25/03/2026
GlycoDiveR: a modular R framework to analyze and visualize highly dimensional glycoproteomics data www.biorxiv.org/cont... --- #proteomics #prot-preprint
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 13/03/2026
Exciting new discovery from @jimwellsucsf.bsky.social and coworkers, a new class of potential cancer antigens flipped onto the cell surface via autophagy-associated exocytosis, featuring first author and former PhD student Corleone Delaveris! #proudofalumni
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Elisa Fadda @elisafadda.bsky.social · 02/03/2026
Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...
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Nick Riley @nmriley.bsky.social · 27/02/2026
MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10
The mass range of tandem mass spectra can be categorized into three main regions. For glycopeptides, the lower mass range contains mainly oxonium ions, the middle range contains mainly peptide fragments, and the high range contains charge-reduced fragments. All regions contain valuable fragment ion information, but they can only be simultaneously accessed by breaking the 5–10–15 rule.
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Megan Priestley @megtriesscience.bsky.social · 26/02/2026
One month left to submit abstracts! Deadline is 22nd March - don’t miss out 🤝
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Nick Riley @nmriley.bsky.social · 10/02/2026
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry: pubs.acs.org/doi/abs/10.1...
pubs.acs.org
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
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Nick Riley @nmriley.bsky.social · 10/02/2026
A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry: pubs.acs.org/doi/abs/10.1...
pubs.acs.org
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona
Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...
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Emmajay Sutherland @emmajays.bsky.social · 09/01/2026
2025 ended with this paper being accepted by Analytical Chemistry! 😁 Please check out our article in its new home and learn how these multinanoparticle protein coronas grant us a deeper insight into the glycoproteome of different biofluids: pubs.acs.org/doi/10.1021/...
pubs.acs.org
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Nature Biotechnology @natbiotech.nature.com · 16/12/2025
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
go.nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Eric Topol @erictopol.bsky.social · 16/12/2025
A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...
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Nick Riley @nmriley.bsky.social · 14/12/2025
It was a great meeting at OHSU, and it’s always fun to connect with @carolynbertozzi.bskyverified.social alum!
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Jeremy Baskin @jeremybaskin.bsky.social · 14/12/2025
Had a blast at the OHSU Chemical Biology & Physiology meeting this week! Amazing talks, great to see lab alum Brittany White-Mathieu’s developing program at UNH, reconnect with friends and collaborators, meet some of the next generation of #chembio, and explore Portland!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 08/12/2025
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏 www.biorxiv.org/content/10.6...
biorxiv.org
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
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Nick Riley @nmriley.bsky.social · 25/11/2025
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings? Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026. acsanalytical.org/undergraduat...
acsanalytical.org
Awards for Undergraduate Students
Visit the post for more.
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glycoexpasy.bsky.social @glycoexpasy.bsky.social · 25/11/2025
And of course thanks to all co-authors and hopefully reaching out to future users @gundrylab.bsky.social @nmriley.bsky.social @khookh.bsky.social @cashwood.proteaglyco.com @wandalllab.bsky.social @glyconet.bsky.social and so many I cannot include...
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Nick Riley @nmriley.bsky.social · 25/11/2025
Do you know outstanding undergraduate researchers who could use up to $1,000 in travel funding to present their work at the Spring @acs.org or @pittcon.bsky.social Meetings? Please encourage them to apply for a Kolthoff award! Deadline is Jan. 12, 2026. acsanalytical.org/undergraduat...
acsanalytical.org
Awards for Undergraduate Students
Visit the post for more.
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 19/11/2025
Know an inspiring early-career chemist? Nominate an early-career chemist for the 2026 Talented 12 at cen.acs.org/sections/tal... Submit your nomination by January 20, 2026. #CENT12 #MassSpec #Chemistry
Who Inspires you? In the annual Talented 12 program, C&EN highlights extraordinary early-career chemists shaping the future of chemistry.
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 17/11/2025
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange. youtu.be/LutI8YqJkqM?...
youtu.be
Nobel Minds 2022
YouTube video by Nobel Prize
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Science Magazine @science.org · 13/11/2025
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists. 🎉 Learn more about the work: scim.ag/4qVpK1a
Uche Medoh
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Matthew Macauley @siglecdude.bsky.social · 12/11/2025
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
science.org
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
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UW Genome Sciences @uwgenome.bsky.social · 12/11/2025
Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO! us-hupo.org/Computationa...
us-hupo.org
US HUPO - Computational Proteomics Award
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UW Genome Sciences @uwgenome.bsky.social · 12/11/2025
Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO! us-hupo.org/Distinguishe...
us-hupo.org
US HUPO - Distinguished Contribution Award
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Riley Research Group @riley-research.bsky.social · 11/11/2025
Have fun with the poster presentation today @timveth.bsky.social!
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Nick Riley @nmriley.bsky.social · 10/11/2025
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego. I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
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Nick Riley @nmriley.bsky.social · 10/11/2025
@timveth.bsky.social is not only attending #SFG2025 - he helped organize Glycopalooza events for early career researchers and is presenting poster B10-110 Tuesday. Check it out in session 2 to hear his impressive work integrating bottom-up and top-down methods to define glycoproteoform heterogeneity
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Nick Riley @nmriley.bsky.social · 10/11/2025
Not only did Kayla do a great job with her #HUPO2025 presentation, but she also was recognized this afternoon as one of the winners of the competitive 2025 Quantitative Proteomics Grant from Thermo Fisher Scientific. Way to go, Kayla!
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Nick Riley @nmriley.bsky.social · 10/11/2025
The overlap of #HUPO2025 with #SFG2025 this week means I’m missing out on the #glycotime fun at SFG in San Diego. I am happy postdoc @timveth.bsky.social is able to represent @riley-research.bsky.social at SFG instead!
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Nick Riley @nmriley.bsky.social · 09/11/2025
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom! My poster on our recent work informatics tools is on Monday afternoon too. See you there! #glycotime
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Nick Riley @nmriley.bsky.social · 09/11/2025
If you are at #HUPO2025 and want to see some recent work from @riley-research.bsky.social, come check out Kayla’s talk on Monday afternoon in the Glycoproteomics session in the Frontenac Ballroom! My poster on our recent work informatics tools is on Monday afternoon too. See you there! #glycotime
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PastelBio @pastelbio.bsky.social · 22/10/2025
Understanding m/z range settings for MS/MS scans: a case study with intact glycopeptides chemrxiv.org/engage/... --- #proteomics #prot-preprint
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Nick Riley @nmriley.bsky.social · 16/10/2025
Our manuscript describing @riley-research.bsky.social's GlyCounter informatics tool is now in press at Molecular and Cellular Proteomics. Congrats to first-author Katie Kothlow, her first first-author paper! The manuscript is available here: www.mcponline.org/article/S153...
mcponline.org
Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter
Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...
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Riley Research Group @riley-research.bsky.social · 27/09/2025
Awesome to see GlyCounter at work! www.biorxiv.org/content/10.1...
biorxiv.org
Extracting informative glycan-specific ions from glycopeptide MS/MS spectra with GlyCounter
Glycopeptide tandem mass spectra typically contain numerous glycan-specific fragments that can inform several features of glycan modifications, including glycan class, composition, and structure. Whil...
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