iiinova — where your digital self keeps evolving

Reposted by Dena Dubal

Ashley Webb, PhD @aewebb.bsky.social · 05/03/2026

✨Registration is OPEN for the 2026 FASEB on Epigenetics in Aging and Disease in Malahide, Ireland!✨ Featuring @denadubal.bsky.social and Yang Shi from @ludwigcancer.bsky.social as Keynotes. Speaker slots available! With: @bbparis1984.bsky.social Ashby Morrison, Ernesto Guccione

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Dena Dubal @denadubal.bsky.social · 13/10/2025

Five years ago Sam Dubal ascended - into the arms of the Mother Mountain. So blessed to have been the sister of this surgeon-anthropologist with a gentle heart and fierce mind. He was shifting paradigms toward a better world - with that unassuming smile.

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Reposted by Dena Dubal

Veena Dubal @veenadubal.bsky.social · 16/09/2025

Today, I had an amazing, unexpected surprise. My big sister came to UC Irvine and sat in on my lecture! It was an amazing, memorable moment. I’ll never forget it. 😭❤️ love you @denadubal.bsky.social

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Reposted by Dena Dubal

American Federation for Aging Research (AFAR) @afar.org · 04/08/2025

The Wall Street Journal recently highlighted AFAR grantees @denadubal.bsky.social, @jennifergarrison.bsky.social and @jamienjustice.bsky.social in a feature on pioneering women advancing aging research. Read the full article here: www.wsj.com/health/welln...

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · 13/06/2025

📣 We are thrilled to announce @denadubal.bsky.social is joining our Executive Committee! Dr. Dubal's research investigates the molecular mechanisms of #aging, #resilience, and #neurodegenerative_disease. #SciSky #GeroSky

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Dena Dubal @denadubal.bsky.social · 25/05/2025

We celebrated with chocolate, stories and tacos! Congrats Samira @jusabdulsam.bsky.social on starting the next chapter of your scientific journey as you set up your own lab at @templeuniversity.bsky.social @ucsfhealth.bsky.social @simonsfoundation.org

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Dena Dubal @denadubal.bsky.social · 23/04/2025

With gratitude for the Pignolo Prize in Aging Research from UPENN @upenn.bsky.social . Thanks David Wok, Edward Lee, John Pignolo, Virginia Lee - and others. Wonderful occasion!

Daniel Burke Photography of the occasion.

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Dena Dubal @denadubal.bsky.social · 17/04/2025

"We have far to go and more to do" - thanks Katherine Bourzac @bourzac.bsky.social at @nature.com for including me in this thoughtful piece and highlighting our work on the X chromosome. Why women experience #Alzheimer’s disease differently from men www.nature.com/articles/d41...

nature.com

Why women experience Alzheimer’s disease differently from men

Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.

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Dena Dubal @denadubal.bsky.social · 12/04/2025

Congratulations @margaretgadek.bsky.social on a wildly successful PhD! On to the MD!

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · 11/03/2025

Could a reawakening of the silenced X chromosome in females help slow aging-induced cognitive decline? Check out the work by @denadubal.bsky.social along with colleagues Kaitlin Casaletto, Bérénice Benayoun, and Vijay Ramani in Science Advances: bit.ly/3FlN3hj #GeroSky #SciSky

science.org

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

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Dena Dubal @denadubal.bsky.social · 07/03/2025

"A little boost went a long way". Increasing an X factor from the silent X improved cognition in aging male and female mice. Privileged to have our discovery reported in @nytimes.com, alongside findings from Kaitlin Casaletto and Rachel Buckley @bucklr01.bsky.social. www.nytimes.com/2025/03/05/h...

nytimes.com

Aging Women’s Brain Mysteries Are Tested in Trio of Studies (Gift Article)

Researchers identified a gene that seems to help slow brain aging in women, and studied links between hormone therapy, menopause and Alzheimer’s.

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Dena Dubal @denadubal.bsky.social · 06/03/2025

Thanks Katherine Bourzac @bourzac.bsky.social for this terrific article in @nature.com on our discovery that the "silent X awakens"!

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Dena Dubal @denadubal.bsky.social · 06/03/2025

"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...

science.org

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

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Reposted by Dena Dubal

Katherine Bourzac @bourzac.bsky.social · 05/03/2025

Thanks to @denadubal.bsky.social and @bucklr01.bsky.social for talking to me for this story about the fascinating X chromosome!

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Reposted by Dena Dubal

Margaret Gadek @margaretgadek.bsky.social · 05/03/2025

Our new Science Advances paper reveals activation of the silent X chromosome as a mechanism of female resilience in cognitive aging www.science.org/doi/10.1126/... Many thanks to @denadubal.bsky.social for your mentorship on this project!!

science.org

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

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Reposted by Dena Dubal

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · 05/03/2025

Excited to share our new review article in @cp-trendsgenetics.bsky.social together with the labs of @denadubal.bsky.social, @ctmurphy1.bsky.social and #YousinSuh, spearheaded by trainees Victor Ansere, Seung-Soo Kim, Francesca Marino and Katherine Morillo! 🧪🧬🖥️ www.sciencedirect.com/science/arti...

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Dena Dubal @denadubal.bsky.social · 26/02/2025

Wonderful talking with Mohana Ravindranath @ravindranize.bsky.social for her compelling article – Why do Women Live Longer than Men? Input from @bbparis1984.bsky.social and others @nytimes.com www.nytimes.com/2025/02/25/w...

nytimes.com

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Reposted by Dena Dubal

Simons Foundation @simonsfoundation.org · 06/02/2025

Why do women’s brains age better than men’s? A new Simons Foundation–funded @nature.com study from @denadubal.bsky.social identifies a key player: the X chromosome. Read more: www.simonsfoundation.org/2025/02/05/n... #science #neuroscience

simonsfoundation.org

New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome

New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome on Simons Foundation

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Reposted by Dena Dubal

American Federation for Aging Research (AFAR) @afar.org · 29/01/2025

New research by AFAR Grantee @denadubal.bsky.social of @ucsfhealth.bsky.social recently published in @nature.com on the maternal X chromosome and cognition and brain aging in female mice.

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Reposted by Dena Dubal

Bakar Aging Research Institute @ucsfaging.bsky.social · 03/02/2025

👏 Don't miss Samira Abdulai-Saiku's manuscript published in @nature.com! Great work coming from @denadubal.bsky.social's lab, furthering our understanding of the relationship between the X chromosome and brain aging. www.nature.com/articles/s41...

nature.com

The maternal X chromosome affects cognition and brain ageing in female mice - Nature

The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus.

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Reposted by Dena Dubal

Waggoner Lab @labwaggoner.bsky.social · 22/01/2025

Older female mice show poor spatial memory when their paternal X chromosome is inactive and only the maternal copy is active @nature.com @denadubal.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...

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Reposted by Dena Dubal

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · 24/01/2025

Beautiful study from @denadubal.bsky.social and #SamiraAbdulaiSaiku showing that the parent-of-origin of the active X in mice play a huge role in #brain aging!!!! Congrats on this transformative work!

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Reposted by Dena Dubal

Sarah CP Williams @sarahcpwilliams.bsky.social · 24/01/2025

Is brain aging mom's fault? When brain cells rely only on X chromosomes inherited from mom, they age more quickly, UCSF researchers led by @denadubal.bsky.social reported in @nature.com. Reversing the effect could help treat brain diseases or memory loss. www.ucsf.edu/news/2025/01...

ucsf.edu

Could Brain Aging Be Mom’s Fault?

Researchers found that female mice using only maternal X chromosomes showed faster cognitive decline, which could help explain the variation in brain aging between the sexes

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Reposted by Dena Dubal

Bérénice A. Benayoun, PhD @bbparis1984.bsky.social · 08/01/2025

Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging. See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic: www.sciencedirect.com/science/arti... #GeroSky #SexDifferences

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Dena Dubal @denadubal.bsky.social · 08/01/2025

Male-Female comparisons are powerful in Biomedical Research. More on this and what is a "Pink Box Warning"?? From @ctmurphy1.bsky.social @bbparis1984.bsky.social Yousin Suh and me in the latest issue of Neuron www.sciencedirect.com/science/arti...

sciencedirect.com

Biological sex matters in brain aging

Every cell in the body has a biological sex. The expansion of aging research to investigate female- and male-specific biology heralds a major advance …

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Dena Dubal @denadubal.bsky.social · 12/12/2024

With gratitude for the lovely visit to @ucirvine.bsky.social hosted by the md/phd students. Enjoyed time with @elizabethhead.bsky.social, Kim Green, Frank LaFerla, Claudia Kawas, Matthew Blurton-Jones, and Michael Leon. Thanks @nelliekwang.bsky.social!

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