Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

β cells are dysfunctional in type 2 diabetes (T2D) and congenital hyperinsulinism (HI), but the mechanisms linking hypersecretion to β cell failure ar…

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...

Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate...

Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing cholangitis, an incurable autoimmune liver...

Cholesterol lowering medication positively affects anti-cancer immune response, but the underpinning mechanism is not fully known. Here authors show that the effect is mediated by specific cholesterol...

imageimageAblation of RIPK1 in αβT cells results in spontaneous proximal small intestinal pathology, characterized by microbiome-mediated epithelial hyperproliferation and TNF-driven villus atrophy, u...

npj Vaccines - Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy

Mitochondria play a key role in cellular metabolism. Here, authors develop a Variational Autoencoder to design novel mitochondrial targeting sequences, validating them across several eukaryotic organi...

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

Khavari and colleagues show that free glucose accumulation accompanies differentiation. Free glucose itself is required for terminal differentiation in the epidermis and binds to various cellular prot...

Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that pa…

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

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Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

The United States can no longer keep tabs on drug-resistant gonorrhea, among other infections, scientists said.

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

In shock move, four institute directors at the US biomedical agency are removed from their posts.

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

Ending clinical trials with no warning can put patients at risk.

Trump’s horrible, terrible, no good, very bad week

The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...

Mitochondrial dynamics and metabolites reciprocally influence each other. In this study, Tang et al. discover a role of β-hydroxybutyrate (BHB) in regulating mitochondrial functions. BHB promotes the ...

Abstract. Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, muco

This university crisis is a grim scrabble for numbers

imageimageThe bioenergetic requirements of muscle stem cells (satellite cells) during homeostasis and regeneration remain ill-defined. Here, genetics combined with multi-omics analyses reveal an essen...

More than 90 studies on threats such as climate change, extremism, and disinformation are halted