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Shane Herbert

@shaneherbert.bsky.social
203 followers 225 following 8 posts

Cell & developmental biologist. Exploring instructive cues encoded in cell shape – in vascular development, morphogenesis and beyond. herbertlab.com @uniofmanchester.bsky.social @fbmh-uom.bsky.social @mcf-uom.bsky.social

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Reposted by Shane Herbert
Nature Cell Biology @natcellbio.nature.com · 02/08/2025
🍹Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control. bit.ly/4mhMvsU
bit.ly
Cell state-specific cytoplasmic density controls spindle architecture and scaling - Nature Cell Biology
Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...
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Shane Herbert @shaneherbert.bsky.social · 01/08/2025
If you’ve ever wondered how cells tune positioning of organelles in response to cell shape change, and what happens when this goes wrong, please check out our new manuscript – mRNA trafficking controls cell-size-scaled organelle dynamics! www.nature.com/articles/s41...
nature.com
mRNA trafficking directs cell-size-scaling of mitochondria distribution and function - Nature Communications
How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-sca...
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Reposted by Shane Herbert
Anzy Miller @anzymiller.bsky.social · 03/07/2025
Looking foward to the Northern(ish) Developmental Biology Meeting 2025 next week @sheffielduni.bsky.social! Thanks to the organisers @shaneherbert.bsky.social Raman Das @tsakiridis.bsky.social @kyracampbelllab.bsky.social
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Shane Herbert @shaneherbert.bsky.social · 09/05/2025
Frictiotaxis - amazing!
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Shane Herbert @shaneherbert.bsky.social · 09/05/2025
Cool - ever multitalented endothelial cells!
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Shane Herbert @shaneherbert.bsky.social · 09/05/2025
It's great to have media attention on our recent paper, but, some of these 'news' articles are completely wacky! 🤣
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Shane Herbert @shaneherbert.bsky.social · 09/05/2025
I really hope I can make this - and seems crazy that this is the 1st UK meeting! Should be excellent!
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Shane Herbert @shaneherbert.bsky.social · 07/05/2025
Bit of a nerdy dream for our paper to be covered by @newscientist.com! And lovely kind words from @buzzbaum.bsky.social. Just a shame that the daughter cells on the cover image are round and symmetric 🤣. www.newscientist.com/article/2478... www.newscientist.com/article/2478...
newscientist.com
Our cells can divide in a completely unexpected way
A different kind of human cell division could improve our understanding of cancer and help us grow specific tissues
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Shane Herbert @shaneherbert.bsky.social · 06/05/2025
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
science.org
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
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