Good Sunday, all! A wonderful summary of papers in #cancermetabolism and #mitochondrialbiology is out. Don't miss it! https://lnkd.in/e__jSvjE Biomed News mitoworld.org #keepreading "How often in li...

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Most of our cells contain mitochondria and rely on them for signaling, information processing, energy transformation, and other essential functions. So when a genetic mutation affects mitochondria, ...

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Cells face a continual metabolic decision: should fatty acids be stored for later, or mobilized and burned for energy? Mitochondria sit at the heart of both processes. Although they are best known for...

Cell-mediated immunity requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Here, D-α-hydroxybutyrate (DAHB) is shown to act as a metabolic adjuvant, driving the conversion of proliferating CD8+ T cells into cytotoxic effector cells by linking mitochondrial ATP production to chromatin remodeling and gene expression.

Das et al. show that succinate regulates mitochondrial protein import through an interaction between Sfc1 (succinate-fumarate carrier) and the Tim23 translocase subunit. In the absence of succinate, Sfc1 associates with Tim23 and reduces protein import. Succinate promotes dissociation of the Sfc1-Tim23 complex, thereby enhancing TIM23 mediated protein translocation into mitochondria.

In their work, Windisch et al. demonstrate the successful adaptation of volumetric 3D printing to photosynthetically active green microalgae-based engineered living materials (ELMs), addressing key fa...

The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial p...

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Here is our fresh selection of papers on #Mitochondria in #Health & #Disease published last week! https://lnkd.in/e_VnGv7y #MitochondrialDisease 📚 Among highlights ➡️ Leucine-rich repeat kinase 2 im...

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Mitochondrial DNA (mtDNA) encodes core subunits of the oxidative phosphorylation machinery, and its expression is spatially organized, with the genome packaged into nucleoids around which transcriptio...

A new collection of papers summarizing the research published last week on #Mitochondria in #Health & #Disease! 📚 https://lnkd.in/e-D3BaTs Among highlights: ➡️ A genetic switch involving EGR1 and EZH...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

Aging kidneys exhibit mitochondrial structural defects, oxidative stress, fibrosis, and altered metabolism. A new study published in Aging Cell suggests that alterations in the mitochondrial contact s...

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Dysfunctional mitochondria are associated with serious diseases (e.g., neurodegenerative disorders, heart failure), and transplantation of healthy mitochondria to diseased cells has been suggested as ...

A multi-institute research team, led by Arupratan Das, sought to find possible drugs to treat glaucoma. Using a high throughput mitochondrial screen in retinal ganglion cells (RGCs), they identified t...

A screen of iPS cells recently identified sildenafil as a potential treatment for Leigh syndrome (LS). Moreover, further testing of the drug showed marked improvement in animal models and human patien...

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...