Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.

Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...

Fetal liver–derived ILC progenitors seed peripheral tissues and generate local ILCs independently of the bone marrow throughout life.

Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.

CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.

Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.

Refractory PsA patients exhibit dysregulated immunoproteasome and MHC-I machinery, highlighting potential therapeutic targets.

PSGL-1 acts as a phagocytosis checkpoint to promote tumor immune escape through impeding LFA-1 activation in macrophages.

Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses.