Classically, B and T cells are differentiated by their mutually exclusive expression of surface markers such as CD3 and CD20, but it is now establi...

The FDA agreed to speed its review of a Roche drug the developer says could be the first oral high-efficacy therapy approved for two MS types.

T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-s...

Background Epidemiological evidence has established a central role of Epstein-Barr virus (EBV) in the pathogenesis of multiple sclerosis (MS). While EBV-specific T-cell responses may influence disease...

By exploring five enduring “negative spaces” in multiple sclerosis (MS) research, Kaufmann, Gold and Fugger challenge simple explanations of disease pathogenesis. Their Comment argues that MS emerges ...

Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-rel...

Abstract. We present a significant update to VDJdb, introducing substantial enhancements to both the data content and the technical infrastructure. The int

BackgroundMemory T cells are records of clonal expansion from prior immune exposures such as infections, vaccines and chronic diseases. Some of the receptors...

Background and ObjectivesInfection with the Epstein-Barr virus is a prerequisite for the development of multiple sclerosis (MS). Recent evidence has identified an antibody response against a peptide r...

Susac syndrome (SuS) is a rare brain, retina, and inner ear endotheliopathy, in which CD8⁺ T cells are thought to target the microvascular endothelium. We applied unbiased, HLA-restricted antigen-spec...

Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS r...

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Treatment targeting progressive multiple sclerosis (MS) have limited efficacy, as central nervous system (CNS) resident B cells are resistant to peripheral B cell depletion by antiCD20 monoclonal anti...

Farooq et al. show that B cell depletion in multiple sclerosis indirectly disrupts a proinflammatory-cytotoxic T cell state. Convergent evidence across dis

The filing acceptance is based on positive results from the Phase III METEOROID study, which showed that Enspryng provided consistent, clinically meaningful improvements for people living with MOGAD.

Objective We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECM...

Intravenous methylprednisolone pulse therapy administered for asymptomatic gadolinium-enhancing lesions was not associated with a statistically significant reduction in the formation of chronic T1 black holes over a 6-month follow-up period.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Continuation of Modifications to Peer Review Practices NOT-OD-26-114. NIH

Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation and cytokine production f...

Memory CD8+ T cells provide accelerated protection against intracellular pathogens and tumors. Circulating memory T cells recirculate through blood and lymph...

An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...

Inducing antigen-specific immune tolerance is a long-standing aim in organ-specific autoimmune diseases including multiple sclerosis (MS). We devel...