Aims/hypothesis Harmine and other small-molecule inhibitors of the kinase, dual tyrosine-regulated kinase 1A (DYRK1A), induce human beta cells to replicate and regenerate in vitro and in vivo and are…

Diabetologia -

Mereu et al. present ESPACE, a single-cell multi-omic atlas of the human pancreas spanning fetal development, adulthood, and type 2 diabetes. Combining transcriptomics, chromatin accessibility, and spatial imaging, they uncover a rare population of plastic centroacinar cells and hidden diversity among hormone-producing islet cells, informing pancreas regeneration and disease.

The decline in first-phase insulin response (FPIR) during the presymptomatic period of type 1 diabetes (T1D) is well established. In-situ functional studies with pancreas tissue slices showed that β-c...

Accumulation of DNA damage drives β-cell dysfunction, senescence, and death in type 1 and type 2 diabetes. Although α-cell dysfunction also contributes to

Pancreatic β-cells undergo different stress responses during the development of type 1 diabetes (T1D), such as the type I interferon (IFN) response and senescence. Although the IFN response leads t...

The mechanisms coordinating the homeostasis of glucose, lactate, fatty acids, and ketones remain unknown. Through quantitative modeling and experiments, Weilandt et al. reveal that these nutrients compete to be oxidized to meet systemic energy demands. Competitive catabolism normally produces homeostasis but, in obesity, converts increased lipolytic propensity into hyperglycemia and hyperinsulinemia.

Stem-cell-derived β-like-cells (SCβ-cells) provide a promising platform for diabetes modelling and cell replacement therapy, but their incomplete functional maturation remains a challenge. Here, we co...

Aaron Cox, PhD, previews a presentation at the 2026 Scientific Sessions. Attendees in New Orleans can watch the session in-person Saturday, June 6, at 3:15 p.m. CT.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI): Inviting Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan for Fis...

Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset i...

β cell stress not only drives loss of functional β cell mass but also may fuel autoimmunity in type 1 diabetes.

Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

Preza et al. show that DEC1, a circadian clock regulator, promotes mature insulin responses to glucose stimulation in human stem cell-derived islet organoids. DEC1 is restricted to maturing β cells, w...

Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

Please fill out your details below if you are interested in receiving updates on the Metabolism in Development and Physiology seminar series. This seminar series will take place every second Thursday ...

Huber et al. used live pancreas slices from donors with recently diagnosed type 1 diabetes to reveal beta cell dysfunction independent of local immune cells. Real-time imaging and molecular analyses u...

Blood glucose homeostasis relies on the well-coordinated rhythmic activity of millions of islets throughout the pancreas. Islet rhythmicity is triggered by glucose elevation and mediated by paracrine ...

β cells are dysfunctional in type 2 diabetes (T2D) and congenital hyperinsulinism (HI), but the mechanisms linking hypersecretion to β cell failure ar…

Efforts to generate mature stem cell-derived β (SC-β) cells have been ongoing for decades, yet their functional performance still falls short of prima…

Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancr

While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...